PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Han003143
Organism
Helianthus annuus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Heliantheae alliance; Heliantheae; Helianthus
Family ERF
Protein Properties Length: 218aa    MW: 24639.9 Da    PI: 10.2862
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Han#S48333732PU_unrefUnigeneView CDS
PUT-169a-Helianthus_annuus-61545PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP260.73.3e-19115164255
        AP2   2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 
                +y+G+r+++ +g+W+AeIrdp++     r++lg+f taeeAa+a++  +++++g
  Han003143 115 QYRGIRQRP-WGKWAAEIRDPRK---GVRVWLGTFNTAEEAARAYDVEARRIRG 164
                6********.**********954...4**********************99997 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.730.106.2E-33115173IPR001471AP2/ERF domain
CDDcd000183.77E-32115174No hitNo description
SMARTSM003803.9E-38115178IPR001471AP2/ERF domain
PROSITE profilePS5103224.052115172IPR001471AP2/ERF domain
SuperFamilySSF541712.16E-22115173IPR016177DNA-binding domain
PfamPF008474.1E-12116164IPR001471AP2/ERF domain
PRINTSPR003674.6E-12116127IPR001471AP2/ERF domain
PRINTSPR003674.6E-12138154IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 218 aa     Download sequence    Send to blast
MCGGAIISDL IAPSVNKSRR LTAADLLLTQ SDFFKNPSKC YSKPLRSEIF DLEDEFEADF  60
RGFKDEVEAQ VEAEHRLNPY NFSASKGSAA SSRGSKSVKS DDVSEKSTSR KRKNQYRGIR  120
QRPWGKWAAE IRDPRKGVRV WLGTFNTAEE AARAYDVEAR RIRGDKAKVN FPDVPVNLNR  180
QKVNVKLNKK TTADCNGSFG YFEPKPQVTF PALLKIWV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2gcc_A1e-21115172563ATERF1
3gcc_A1e-21115172563ATERF1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Han.3370.0embryo
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Highly expressed in seedlings, leaves, flowers, siliques and germinating seeds. {ECO:0000269|PubMed:22020282}.
UniprotTISSUE SPECIFICITY: Mostly expressed in stems and leaves, and, to a lower extent, in roots, siliques and flowers. {ECO:0000269|PubMed:18836139, ECO:0000269|PubMed:9192694}.
Functional Description ? help Back to Top
Source Description
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250, ECO:0000269|PubMed:9159183}.
UniProtTranscription factor involved in the activation of hypoxic gene expression and in ethylene response. Partially redundant with RAP2-2. Acts as a downstream regulator in the ethylene signaling pathway. {ECO:0000269|PubMed:22020282, ECO:0000269|PubMed:22530619}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By 1-aminocyclopropane-1-carboxylic acid (ACC, ethylene precursor), methyl jasmonate (MeJA), and Botrytis cinerea. Also induced by cadmium. {ECO:0000269|PubMed:18836139, ECO:0000269|PubMed:9159183}.
UniProtINDUCTION: Up-regulated by hypoxia but not by ethylene. {ECO:0000269|PubMed:22020282}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021989922.11e-140ethylene-responsive transcription factor RAP2-12
SwissprotP427367e-41RAP23_ARATH; Ethylene-responsive transcription factor RAP2-3
SwissprotQ9SSA81e-40RA212_ARATH; Ethylene-responsive transcription factor RAP2-12
TrEMBLA0A251TPI31e-139A0A251TPI3_HELAN; Putative related to AP2 2
STRINGXP_009775920.11e-70(Nicotiana sylvestris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G16770.15e-39ethylene-responsive element binding protein
Publications ? help Back to Top
  1. Bueso E, et al.
    The lithium tolerance of the Arabidopsis cat2 mutant reveals a cross-talk between oxidative stress and ethylene.
    Plant J., 2007. 52(6): p. 1052-65
    [PMID:17931347]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Chen YC, et al.
    Root defense analysis against Fusarium oxysporum reveals new regulators to confer resistance.
    Sci Rep, 2014. 4: p. 5584
    [PMID:24998294]
  4. Kosmacz M, et al.
    The stability and nuclear localization of the transcription factor RAP2.12 are dynamically regulated by oxygen concentration.
    Plant Cell Environ., 2015. 38(6): p. 1094-103
    [PMID:25438831]
  5. Deslauriers SD,Alvarez AA,Lacey RF,Binder BM,Larsen PB
    Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis.
    New Phytol., 2015. 208(2): p. 442-55
    [PMID:25988998]
  6. Bui LT,Giuntoli B,Kosmacz M,Parlanti S,Licausi F
    Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana.
    Plant Sci., 2015. 236: p. 37-43
    [PMID:26025519]
  7. Gasch P, et al.
    Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis.
    Plant Cell, 2016. 28(1): p. 160-80
    [PMID:26668304]
  8. Gonzali S, et al.
    Universal stress protein HRU1 mediates ROS homeostasis under anoxia.
    Nat Plants, 2015. 1: p. 15151
    [PMID:27251529]
  9. Paul MV, et al.
    Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia.
    Plant Physiol., 2016. 172(1): p. 141-53
    [PMID:27372243]
  10. Shahzad Z, et al.
    A Potassium-Dependent Oxygen Sensing Pathway Regulates Plant Root Hydraulics.
    Cell, 2016. 167(1): p. 87-98.e14
    [PMID:27641502]
  11. Yao Y, et al.
    ETHYLENE RESPONSE FACTOR 74 (ERF74) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)-dependent mechanism in response to different stresses in Arabidopsis.
    New Phytol., 2017. 213(4): p. 1667-1681
    [PMID:28164334]
  12. Liu W, et al.
    Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency.
    Biochem. Biophys. Res. Commun., 2017. 491(3): p. 862-868
    [PMID:28390898]
  13. Giuntoli B,Licausi F,van Veen H,Perata P
    Functional Balancing of the Hypoxia Regulators RAP2.12 and HRA1 Takes Place in vivo in Arabidopsis thaliana Plants.
    Front Plant Sci, 2017. 8: p. 591
    [PMID:28487707]
  14. Yao Y,Chen X,Wu AM
    ERF-VII members exhibit synergistic and separate roles in Arabidopsis.
    Plant Signal Behav, 2017. 12(6): p. e1329073
    [PMID:28537474]
  15. Eysholdt-Derzsó E,Sauter M
    Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling.
    Plant Physiol., 2017. 175(1): p. 412-423
    [PMID:28698356]
  16. Giuntoli B, et al.
    Age-dependent regulation of ERF-VII transcription factor activity in Arabidopsis thaliana.
    Plant Cell Environ., 2017. 40(10): p. 2333-2346
    [PMID:28741696]