PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000386580
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family bHLH
Protein Properties Length: 204aa    MW: 23534.2 Da    PI: 10.028
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000386580genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH32.71.4e-105096455
                   HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
            HLH  4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55
                   +h e+E +RR+++N++f  Lr ++P+ +      K++Ka+ +  A+ YI +Lq
  MDP0000386580 50 NHVEAEWQRREKLNQRFYALRAVVPNiS------KMDKASLVGDAITYITDLQ 96
                   799***********************66......*****************99 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5088815.2944695IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474595.37E-1747116IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000838.10E-1049100No hitNo description
PfamPF000104.8E-85096IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.4E-1650116IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003533.2E-1152101IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 204 aa     Download sequence    Send to blast
MNRMMVDGFN VQIRVSSSEL LKDESSAQID EGKPRKRGRK PANGREEPLN HVEAEWQRRE  60
KLNQRFYALR AVVPNISKMD KASLVGDAIT YITDLQKKIR VMETEKQMVN KKGKQLPVPE  120
IDFQERLEDA VVRMNCPLDS HPVSEVFRTL RCCARIAPNL MEPTLDNPQK IYQMKCKNKI  180
LKNTKILTRF LNSQCNWSTS SEQ*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A8e-3044128283Transcription factor MYC2
5gnj_B8e-3044128283Transcription factor MYC2
5gnj_E8e-3044128283Transcription factor MYC2
5gnj_F8e-3044128283Transcription factor MYC2
5gnj_G8e-3044128283Transcription factor MYC2
5gnj_I8e-3044128283Transcription factor MYC2
5gnj_M8e-3044128283Transcription factor MYC2
5gnj_N8e-3044128283Transcription factor MYC2
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.128691e-173bud| leaf| stem
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By UV treatment. {ECO:0000269|PubMed:12679534}.
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP6894061e-169KP689406.1 Prunus pseudocerasus isolate Unigene16868 bHLH transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009354912.13e-96PREDICTED: transcription factor bHLH3-like
RefseqXP_009354914.13e-96PREDICTED: transcription factor bHLH3-like
SwissprotA0A3Q7H2163e-59MTB3_SOLLC; Transcription factor MTB3
SwissprotO234872e-59BH003_ARATH; Transcription factor bHLH3
TrEMBLA0A498JSY93e-99A0A498JSY9_MALDO; Uncharacterized protein
STRINGXP_009354912.11e-95(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF29383364
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G16430.11e-61bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Sasaki-Sekimoto Y,Saito H,Masuda S,Shirasu K,Ohta H
    Comprehensive analysis of protein interactions between JAZ proteins and bHLH transcription factors that negatively regulate jasmonate signaling.
    Plant Signal Behav, 2014. 9(1): p. e27639
    [PMID:24394987]
  4. Fonseca S, et al.
    bHLH003, bHLH013 and bHLH017 are new targets of JAZ repressors negatively regulating JA responses.
    PLoS ONE, 2014. 9(1): p. e86182
    [PMID:24465948]
  5. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  6. Ezer D, et al.
    The G-Box Transcriptional Regulatory Code in Arabidopsis.
    Plant Physiol., 2017. 175(2): p. 628-640
    [PMID:28864470]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]