PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID HL.SW.v1.0.G004645.1
Organism
Humulus lupulus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Humulus
Family ARR-B
Protein Properties Length: 663aa    MW: 72774.5 Da    PI: 5.8647
Description ARR-B family protein
Gene Model
Gene Model ID Type Source Coding Sequence
HL.SW.v1.0.G004645.1genomeHOPBASEView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1G2-like90.61.4e-28207260155
               G2-like   1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 
                           kpr++W+ eLH++Fv av+qL G++kA+Pk+ilelm+v+gLt+e+v+SHLQkYRl
  HL.SW.v1.0.G004645.1 207 KPRVVWSVELHQQFVGAVNQL-GIDKAVPKKILELMNVPGLTRENVASHLQKYRL 260
                           79*******************.********************************8 PP
2Response_reg76.88e-26291371109
                           EEEESSSHHHHHHHHHHHHHTTCEEEEEESSHHHHHHHHHHHH..ESEEEEESSCTTSEHHHHHHHHHHHTTTSEEEEEESTTTHHHHH CS
          Response_reg   1 vlivdDeplvrellrqalekegyeevaeaddgeealellkekd..pDlillDiempgmdGlellkeireeepklpiivvtahgeeedal 87 
                           vl+vdD+p+ +++l+++l+   y ev+    +e al+ll+e++  +D+++ D+ mp+mdG++ll++i  e  +lp+i+++a + ++ + 
  HL.SW.v1.0.G004645.1  29 VLVVDDDPTCLMILEKMLRTCLY-EVTKRNRAEHALNLLRENKngFDVVISDVHMPDMDGFKLLERIGLEM-DLPVIMMSADDGKDVVM 115
                           89*********************.***************999999**********************6654.8**************** PP

                           HHHHTTESEEEESS--HHHHHH CS
          Response_reg  88 ealkaGakdflsKpfdpeelvk 109
                           + +  Ga d+l Kp+ +e+l +
  HL.SW.v1.0.G004645.1 116 KGVTHGACDYLIKPVRIEALKN 137
                           ******************9986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0363921.2E-1804654IPR017053Response regulator B-type, plant
Gene3DG3DSA:3.40.50.23001.4E-4126168No hitNo description
SuperFamilySSF521727.26E-3526150IPR011006CheY-like superfamily
SMARTSM004481.4E-2927139IPR001789Signal transduction response regulator, receiver domain
PROSITE profilePS5011042.74428143IPR001789Signal transduction response regulator, receiver domain
PfamPF000723.5E-2329137IPR001789Signal transduction response regulator, receiver domain
CDDcd001561.03E-2730142No hitNo description
SuperFamilySSF466898.78E-20204264IPR009057Homeodomain-like
PROSITE profilePS512949.894204263IPR017930Myb domain
Gene3DG3DSA:1.10.10.606.4E-30206265IPR009057Homeodomain-like
TIGRFAMsTIGR015571.7E-24207260IPR006447Myb domain, plants
PfamPF002495.3E-7209259IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009873Biological Processethylene-activated signaling pathway
GO:0010082Biological Processregulation of root meristem growth
GO:0010119Biological Processregulation of stomatal movement
GO:0010150Biological Processleaf senescence
GO:0071368Biological Processcellular response to cytokinin stimulus
GO:0080113Biological Processregulation of seed growth
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 663 aa     Download sequence    Send to blast
MNLSNGKGSM STSTSGAGVS DQFPVGLRVL VVDDDPTCLM ILEKMLRTCL YEVTKRNRAE  60
HALNLLRENK NGFDVVISDV HMPDMDGFKL LERIGLEMDL PVIMMSADDG KDVVMKGVTH  120
GACDYLIKPV RIEALKNIWQ HVVRKKKNEW REIEQSGSVE EGDRQAKPSE EPDYSSSANE  180
GNWRSSKKRK DDEEDGDDRD DSSTLKKPRV VWSVELHQQF VGAVNQLGID KAVPKKILEL  240
MNVPGLTREN VASHLQKYRL YLRRLSGQHQ TNMNNSFMSP QDPTFGPMTS LNGMDLQALA  300
VTGQLPAQSL ATLQAAGLGR STPKSGIPLP IVDQRNLFSF ENPKLRFGEG QQQHLSNGKP  360
LNLLHGIPTS MEPKQLTNLH QSAQSLGMNM QVNPHGSQNS PLLMQMAQAQ SRGPILNESS  420
SGHAPRLPSS VTQPMVTSGV LGRNGISDNG RGSGYNPVMQ NSSMLNFPLN QSSELPGNSF  480
PLGNPPSISG LTSKGAFQED VNSEIKGSAG FMPSYDIFND LNQHKSNDWD IQNVGLTYDA  540
SRQSNSLQGS FDMVNQGFSA GQRNLPVRNQ SNPGKAMFSM GENDHGTSQN INQNLNPHLG  600
DHSVRIKSER IPDDIGNDPG FFPEQFGQDD LMSALLKQQQ EGIAPAENQF DFDGYSLDNI  660
PV*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1irz_A5e-22206266464ARR10-B
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the expression of nuclear genes for components of mitochondrial complex I. Promotes cytokinin-mediated leaf longevity. Involved in the ethylene signaling pathway in an ETR1-dependent manner and in the cytokinin signaling pathway. {ECO:0000269|PubMed:11370868, ECO:0000269|PubMed:11574878, ECO:0000269|PubMed:15282545, ECO:0000269|PubMed:16407152}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00054PBMTransfer from AT4G16110Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024024976.10.0two-component response regulator ARR2 isoform X1
SwissprotQ9ZWJ90.0ARR2_ARATH; Two-component response regulator ARR2
TrEMBLA0A2P5ERM50.0A0A2P5ERM5_TREOI; Two-component response regulator
STRINGXP_010101901.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF39583458
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G16110.10.0response regulator 2
Publications ? help Back to Top
  1. Takahashi N, et al.
    Cytokinins control endocycle onset by promoting the expression of an APC/C activator in Arabidopsis roots.
    Curr. Biol., 2013. 23(18): p. 1812-7
    [PMID:24035544]
  2. Ge XM, et al.
    Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis.
    Plant J., 2015. 82(1): p. 138-50
    [PMID:25704455]
  3. Takahashi N,Umeda M
    Cytokinins promote onset of endoreplication by controlling cell cycle machinery.
    Plant Signal Behav, 2014. 9(8): p. e29396
    [PMID:25763620]
  4. Kobayashi K, et al.
    Shoot Removal Induces Chloroplast Development in Roots via Cytokinin Signaling.
    Plant Physiol., 2017. 173(4): p. 2340-2355
    [PMID:28193764]
  5. Arnaud D, et al.
    Cytokinin-Mediated Regulation of Reactive Oxygen Species Homeostasis Modulates Stomatal Immunity in Arabidopsis.
    Plant Cell, 2017. 29(3): p. 543-559
    [PMID:28254779]
  6. Zhang TQ, et al.
    A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration.
    Plant Cell, 2017. 29(5): p. 1073-1087
    [PMID:28389585]
  7. Meng WJ, et al.
    Type-B ARABIDOPSIS RESPONSE REGULATORs Specify the Shoot Stem Cell Niche by Dual Regulation of WUSCHEL.
    Plant Cell, 2017. 29(6): p. 1357-1372
    [PMID:28576846]
  8. Zhang F,May A,Irish VF
    Type-B ARABIDOPSIS RESPONSE REGULATORs Directly Activate WUSCHEL.
    Trends Plant Sci., 2017. 22(10): p. 815-817
    [PMID:28886911]
  9. Takatsuka H,Higaki T,Umeda M
    Actin Reorganization Triggers Rapid Cell Elongation in Roots.
    Plant Physiol., 2018. 178(3): p. 1130-1141
    [PMID:30185441]