PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Thecc1EG000515t1
Common NameTCM_000515
Organism
Theobroma cacao
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma
Family B3
Protein Properties Length: 692aa    MW: 77612.7 Da    PI: 8.8777
Description B3 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Thecc1EG000515t1genomeCGDView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1B347.23.9e-154781898
                      --HHH.HTT---..--SEEEEEETTS-EEEEEE..EEETTEEEE-TTHHHHHHHHT--TT-EEEEEE-SSSEE..EEEEE- CS
                B3 18 lpkkfaeehggkkeesktltledesgrsWevkliyrkksgryvltkGWkeFvkangLkegDfvvFkldgrsefelvvkvfr 98
                      +p  f++++ g    +k+ +l++ +g+ W v l  +   g+ ++t+GW++F+++n L+ gDf++F++dg+  f   v +f 
  Thecc1EG000515t1  4 IPPAFVRHFYGT--IPKDAMLKNHTGKHWLVDL--EEVEGGLTMTNGWQGFASENSLEFGDFLIFEYDGKCLF--DVEIFG 78
                      999***777444..6789***************..********************************996666..777765 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5086314.677180IPR003340B3 DNA binding domain
SMARTSM010192.6E-4180IPR003340B3 DNA binding domain
SuperFamilySSF1019365.49E-19382IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.102.8E-17382IPR015300DNA-binding pseudobarrel domain
PfamPF023622.5E-12477IPR003340B3 DNA binding domain
CDDcd100175.35E-12477No hitNo description
SuperFamilySSF1019361.18E-5135190IPR015300DNA-binding pseudobarrel domain
Gene3DG3DSA:2.40.330.104.7E-5135191IPR015300DNA-binding pseudobarrel domain
PfamPF000671.4E-84199664IPR001128Cytochrome P450
Gene3DG3DSA:1.10.630.101.9E-122203678IPR001128Cytochrome P450
SuperFamilySSF482641.96E-114205678IPR001128Cytochrome P450
PRINTSPR004637.8E-43228247IPR002401Cytochrome P450, E-class, group I
PRINTSPR004637.8E-43252273IPR002401Cytochrome P450, E-class, group I
PRINTSPR004637.8E-43352370IPR002401Cytochrome P450, E-class, group I
PRINTSPR004637.8E-43471488IPR002401Cytochrome P450, E-class, group I
PRINTSPR003851.5E-13482499IPR001128Cytochrome P450
PRINTSPR004637.8E-43491517IPR002401Cytochrome P450, E-class, group I
PRINTSPR004637.8E-43534552IPR002401Cytochrome P450, E-class, group I
PRINTSPR003851.5E-13535546IPR001128Cytochrome P450
PRINTSPR004637.8E-43575599IPR002401Cytochrome P450, E-class, group I
PRINTSPR004637.8E-43613623IPR002401Cytochrome P450, E-class, group I
PRINTSPR003851.5E-13614623IPR001128Cytochrome P450
PROSITE patternPS000860616625IPR017972Cytochrome P450, conserved site
PRINTSPR004637.8E-43623646IPR002401Cytochrome P450, E-class, group I
PRINTSPR003851.5E-13623634IPR001128Cytochrome P450
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0055114Biological Processoxidation-reduction process
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0004497Molecular Functionmonooxygenase activity
GO:0005506Molecular Functioniron ion binding
GO:0016705Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037Molecular Functionheme binding
Sequence ? help Back to Top
Protein Sequence    Length: 692 aa     Download sequence    Send to blast
MQKIPPAFVR HFYGTIPKDA MLKNHTGKHW LVDLEEVEGG LTMTNGWQGF ASENSLEFGD  60
FLIFEYDGKC LFDVEIFGRN GCNKAALSSN MTTTHAVNEK EIKEVDICNE PTQTCKQKYS  120
VKNLGKALNA ATYVTPKGPY FVSNIPQSMR SAVYVPRSLL ASYGIKIKPE VVLLDQNGKK  180
WPVMSKKSST HRKRVCTAPQ AGGALPVIGH MHLLGGHQLT HKTLGAMADK YGPVFSIRLG  240
SHSALVLNSW EMARECFTVH DKVFSTRPVL TASKVLGYNY AMFGFAPYGS YWREIRRIAT  300
IELLSSHRID MLKHIRASEV KTAVRELYKS WLSKGGGETG VLVDMKQWFG DLTHNIALRM  360
VGGKRFFGPN ADCEEAEARR CQKVMRDSAY LFGVFVVSDA LPFIGWLDFQ GYEKAMKRTA  420
KELDILLGGW LEEHKQKKHL GGGLKKEQDF MDVMLNILED AKITSFDADT INKATCLNLV  480
LAGSDTTMIT LTWALSLLLN NPRVLKRAQD ELDMHVGKDR LLEESDIRNL VYLHAIVKET  540
LRLYPPSPII FRASMEDCTL STGYHIPAGT RLMVNAWKIQ RDERVWPDPH VFKPERFLTS  600
HKDMEFRGQT FELIPFGSGR RSCPGVSLAL QVVHSALASF LQSFEVSKPS KLEDIDMTES  660
TGLTNLKATP LEVLFTPRLD SKLYGLGTEL I*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5ylw_A1e-7019367423490Ferruginol synthase
5ym3_A1e-7019367423490Ferruginol synthase
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtCan hydroxylate xanthotoxin (8-methoxypsoralen) to form 5-hydroxyxanthotoxin (5-hydroxy-8-methoxypsoralen) in vivo and in vitro (PubMed:18291319). Involved in the early iron deficiency response, possibly through an IDE1-like mediated pathway (PubMed:21315474). Involved in the pathway of sideretin biosynthesis from feruloyl CoA, a redox-active catecholic metabolite exuded by roots in response to iron deficiency in order to facilitate the uptake of iron; this pathway consists in the successive conversion from feruloyl CoA to scopoletin, from scopoletin to fraxetin and from fraxetin to sideretin (PubMed:29581584). Catalyzes the biosynthesis of sideretin via fraxetin hydroxylation (PubMed:29581584). {ECO:0000269|PubMed:18291319, ECO:0000269|PubMed:21315474, ECO:0000269|PubMed:29581584}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By iron deficiency, mainly in roots. {ECO:0000269|PubMed:21315474, ECO:0000269|PubMed:29581584}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021300745.10.0LOW QUALITY PROTEIN: cytochrome P450 CYP82D47-like
SwissprotQ9SZ460.0C82C4_ARATH; Xanthotoxin 5-hydroxylase CYP82C4
TrEMBLA0A061DG180.0A0A061DG18_THECC; Cytochrome P450
STRINGEOX912690.0(Theobroma cacao)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G66980.14e-25B3 family protein
Publications ? help Back to Top
  1. Jung S, et al.
    Synteny conservation between the Prunus genome and both the present and ancestral Arabidopsis genomes.
    BMC Genomics, 2006. 7: p. 81
    [PMID:16615871]
  2. Kruse T, et al.
    In planta biocatalysis screen of P450s identifies 8-methoxypsoralen as a substrate for the CYP82C subfamily, yielding original chemical structures.
    Chem. Biol., 2008. 15(2): p. 149-56
    [PMID:18291319]
  3. Murgia I,Tarantino D,Soave C,Morandini P
    Arabidopsis CYP82C4 expression is dependent on Fe availability and circadian rhythm, and correlates with genes involved in the early Fe deficiency response.
    J. Plant Physiol., 2011. 168(9): p. 894-902
    [PMID:21315474]
  4. Motamayor JC, et al.
    The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color.
    Genome Biol., 2013. 14(6): p. r53
    [PMID:23731509]
  5. Rajniak J, et al.
    Biosynthesis of redox-active metabolites in response to iron deficiency in plants.
    Nat. Chem. Biol., 2018. 14(5): p. 442-450
    [PMID:29581584]