PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00000335-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family HD-ZIP
Protein Properties Length: 870aa    MW: 95076.6 Da    PI: 6.3616
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00000335-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox57.13e-1858115457
                            -SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS
               Homeobox   4 RttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57 
                              ++t+eq+e+Le++++++++ps  +r++L +++    +++ +q+kvWFqNrR +ek+
  SMil_00000335-RA_Salv  58 YVRYTAEQVEALERVYAECPKPSSLRRQQLIRECpilsNIEPKQIKVWFQNRRCREKQ 115
                            5789****************************************************97 PP
2START155.15.9e-491944002203
                            HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT. CS
                  START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg. 88 
                            +aee+++e+++ka+ ++  Wv+++ +++g+ ++ +f+ s+++sg a+ra+g+v  ++    +e+l+d++ W +++++ e+      g 
  SMil_00000335-RA_Salv 194 IAEETLTEFLSKATGTAVDWVQMPGMKPGPGSVGIFAISQSCSGVAARACGLVSLEPI-KIAEILKDRPTWFRDCRSLEVFTMFPAGn 280
                            789*******************************************************.7777777777***********99999999 PP

                            .EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE CS
                  START  89 .galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvd 171
                             g+++l +++++a+++l+p Rdf+++Ry+ +l+ g++v++++S++ + + p+    s++vRae++pSg+li+p+++g+s +++v+h  
  SMil_00000335-RA_Salv 281 gGTIELLYTQTYAPTTLAPaRDFWTLRYTTTLENGSLVVCERSLSGTGSGPNaaaASQFVRAEMFPSGYLIRPCDGGGSIIHIVDHLS 368
                            9************************************************9999999******************************** PP

                            --SSXXHHHHHHHHHHHHHHHHHHHHHHTXXX CS
                  START 172 lkgrlphwllrslvksglaegaktwvatlqrq 203
                            l++++++++lr+l++s+ + ++kt+ a+ ++ 
  SMil_00000335-RA_Salv 369 LEAWSVPEVLRPLYESSKVLAQKTTIAAIKYI 400
                            **************************999875 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.14352116IPR001356Homeobox domain
SMARTSM003895.5E-1554120IPR001356Homeobox domain
SuperFamilySSF466894.71E-1656118IPR009057Homeodomain-like
CDDcd000865.05E-1657117No hitNo description
PfamPF000467.8E-1658115IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.603.1E-1859115IPR009057Homeodomain-like
CDDcd146866.12E-6109148No hitNo description
PROSITE profilePS5084826184412IPR002913START domain
CDDcd088755.18E-69188404No hitNo description
SuperFamilySSF559611.37E-32193405No hitNo description
Gene3DG3DSA:3.30.530.202.2E-18193384IPR023393START-like domain
SMARTSM002342.6E-38193403IPR002913START domain
PfamPF018521.4E-46194401IPR002913START domain
PfamPF086705.6E-48723869IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009855Biological Processdetermination of bilateral symmetry
GO:0009944Biological Processpolarity specification of adaxial/abaxial axis
GO:0009956Biological Processradial pattern formation
GO:0010014Biological Processmeristem initiation
GO:0010051Biological Processxylem and phloem pattern formation
GO:0010089Biological Processxylem development
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0008289Molecular Functionlipid binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 870 aa     Download sequence    Send to blast
LAVYLFSLVR ESLSRAAQFI QDTSFGVSSS FTKMAMVAHH HREDSSESIS KHLDAGKYVR  60
YTAEQVEALE RVYAECPKPS SLRRQQLIRE CPILSNIEPK QIKVWFQNRR CREKQRKEST  120
RLQSVNRKLT AMNKLLMEEN DRLQKQVSQL VCENGYMRQH LTPAPTTDAS CESAVTTPQH  180
SLRDASNPAG LLSIAEETLT EFLSKATGTA VDWVQMPGMK PGPGSVGIFA ISQSCSGVAA  240
RACGLVSLEP IKIAEILKDR PTWFRDCRSL EVFTMFPAGN GGTIELLYTQ TYAPTTLAPA  300
RDFWTLRYTT TLENGSLVVC ERSLSGTGSG PNAAAASQFV RAEMFPSGYL IRPCDGGGSI  360
IHIVDHLSLE AWSVPEVLRP LYESSKVLAQ KTTIAAIKYI RQIAQETSGE VVYGLGRQPA  420
VLRTFSQRLS RGFNDAVNGF NDDGWSILNC DGAEDVVIAI SSAKNLNSGS LPILGGVLCA  480
KASMLLQNVP PAVLVRFLRE HRSEWADFNI DAYAAASLKS TYVYPGMRPT KFTGSQIIMP  540
LGHTIEHEEM LEVIRLEGHL LSHEDAFMSR DIHLLQMCSG IDESAVGACA ELVFAPIDEM  600
FPDDAQLLPS GFRIIPLDPK PGDLQESLAL HKTLDLTSSL EVGPAASNNG KVAGGAYSAR  660
SILTIAFQFP FESNLQDNVA SMARQYVRSV ISSVQRVAMA ISPSGISPSI GSKLSPASPE  720
AVTLAHWICQ SYSLHTGAEL LAAESSSSEA LLKSLWHHQD SILCCSLKAV PVFTFANQAG  780
LDMLETTLVT LQDVTLDKIF DDCGRKALFS ELAKIMQQGF AHLPGGICMS TMGRHISYEQ  840
AVVWKVFAED SANASDVHCL ALSFVNWSFV
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269|PubMed:10559440, ECO:0000269|PubMed:11169198, ECO:0000269|PubMed:11402186, ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:22781836, ECO:0000269|PubMed:7555701}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:20807212}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011089294.10.0homeobox-leucine zipper protein REVOLUTA
SwissprotQ9SE430.0REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBLA0A4D9ALS40.0A0A4D9ALS4_SALSN; Homeobox-leucine zipper protein
STRINGMigut.D02228.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA45724140
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G60690.10.0HD-ZIP family protein
Publications ? help Back to Top
  1. Lian H,Li X,Liu Z,He Y
    HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis.
    J. Exp. Bot., 2013. 64(11): p. 3397-410
    [PMID:23918970]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  4. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  5. Roodbarkelari F,Du F,Truernit E,Laux T
    ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    BMC Biol., 2015. 13: p. 74
    [PMID:26358077]
  6. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]