PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT5G60690.1

Common Name

AVB1, IFL, IFL1, MUP24.16, REV

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

HD-ZIP

Protein Properties

Length: 842aa MW: 92438.2 Da PI: 5.8476

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT5G60690.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	56.4	5e-18	25	83	3	57
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57 k ++t+eq+e+Le++++++++ps +r++L +++ +++ +q+kvWFqNrR ++k+ AT5G60690.1 25 KYVRYTAEQVEALERVYAECPKPSSLRRQQLIRECsilaNIEPKQIKVWFQNRRCRDKQ 83 56789***************************************************996 PP
2	START	153.8	1.4e-48	161	366	2	202
HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT..EEEEEEEEX CS START 2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg..galqlmvae 97 +aee+++e+++ka+ ++ Wv+++ +++g++++ +f+ s+ ++g a+ra+g+v +++ +e+l+d++ W +++++ e+ g g+++l +++ AT5G60690.1 161 IAEETLAEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQRCNGVAARACGLVSLEPM-KIAEILKDRPSWFRDCRSLEVFTMFPAGngGTIELVYMQ 257 7899****************************************************.7777777777*******999999999***** PP XTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHHHHHHHHHH CS START 98 lqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrslvksglae 191 ++a+++l+p Rdf+++Ry+ +l g++v++++S++ p+ s++vRae+l Sg+li+p+++g+s +++v+h +l++++++ +lr+l++s+ + AT5G60690.1 258 TYAPTTLAPaRDFWTLRYTTSLDNGSFVVCERSLSGSGAGPNaasASQFVRAEMLSSGYLIRPCDGGGSIIHIVDHLNLEAWSVPDVLRPLYESSKVV 355 *******************************999999989999*********************************************** PP HHHHHHHHTXX CS START 192 gaktwvatlqr 202 ++k++ ++l++ AT5G60690.1 356 AQKMTISALRY 366 ***999987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50071	15.305	20	84	IPR001356	Homeobox domain
SuperFamily	SSF46689	1.11E-16	21	87	IPR009057	Homeodomain-like
SMART	SM00389	2.0E-16	22	88	IPR001356	Homeobox domain
CDD	cd00086	6.22E-16	25	85	No hit	No description
Pfam	PF00046	1.3E-15	26	83	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	3.0E-18	27	80	IPR009057	Homeodomain-like
CDD	cd14686	3.25E-6	77	116	No hit	No description
Gene3D	G3DSA:1.20.5.170	7.7E-4	81	130	No hit	No description
PROSITE profile	PS50848	27.323	151	379	IPR002913	START domain
CDD	cd08875	1.07E-67	155	371	No hit	No description
Gene3D	G3DSA:3.30.530.20	1.7E-19	160	365	IPR023393	START-like domain
SuperFamily	SSF55961	6.87E-35	160	372	No hit	No description
SMART	SM00234	8.3E-38	160	370	IPR002913	START domain
Pfam	PF01852	2.9E-46	161	367	IPR002913	START domain
Pfam	PF08670	6.2E-49	694	841	IPR013978	MEKHLA

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009855	Biological Process	determination of bilateral symmetry
GO:0009944	Biological Process	polarity specification of adaxial/abaxial axis
GO:0009956	Biological Process	radial pattern formation
GO:0010014	Biological Process	meristem initiation
GO:0010051	Biological Process	xylem and phloem pattern formation
GO:0010089	Biological Process	xylem development
GO:0030154	Biological Process	cell differentiation
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008289	Molecular Function	lipid binding
GO:0044212	Molecular Function	transcription regulatory region DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000026	anatomy	primary root tip
PO:0000037	anatomy	shoot apex
PO:0000229	anatomy	flower meristem
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0003015	anatomy	primary root differentiation zone
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009015	anatomy	portion of vascular tissue
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009047	anatomy	stem
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020124	anatomy	root stele
PO:0020137	anatomy	leaf apex
PO:0020148	anatomy	shoot apical meristem
PO:0025022	anatomy	collective leaf structure
PO:0025281	anatomy	pollen
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 842 aa Download sequence Send to blast
MEMAVANHRE RSSDSMNRHL DSSGKYVRYT AEQVEALERV YAECPKPSSL RRQQLIRECS 60 ILANIEPKQI KVWFQNRRCR DKQRKEASRL QSVNRKLSAM NKLLMEENDR LQKQVSQLVC 120 ENGYMKQQLT TVVNDPSCES VVTTPQHSLR DANSPAGLLS IAEETLAEFL SKATGTAVDW 180 VQMPGMKPGP DSVGIFAISQ RCNGVAARAC GLVSLEPMKI AEILKDRPSW FRDCRSLEVF 240 TMFPAGNGGT IELVYMQTYA PTTLAPARDF WTLRYTTSLD NGSFVVCERS LSGSGAGPNA 300 ASASQFVRAE MLSSGYLIRP CDGGGSIIHI VDHLNLEAWS VPDVLRPLYE SSKVVAQKMT 360 ISALRYIRQL AQESNGEVVY GLGRQPAVLR TFSQRLSRGF NDAVNGFGDD GWSTMHCDGA 420 EDIIVAINST KHLNNISNSL SFLGGVLCAK ASMLLQNVPP AVLIRFLREH RSEWADFNVD 480 AYSAATLKAG SFAYPGMRPT RFTGSQIIMP LGHTIEHEEM LEVVRLEGHS LAQEDAFMSR 540 DVHLLQICTG IDENAVGACS ELIFAPINEM FPDDAPLVPS GFRVIPVDAK TGDVQDLLTA 600 NHRTLDLTSS LEVGPSPENA SGNSFSSSSS RCILTIAFQF PFENNLQENV AGMACQYVRS 660 VISSVQRVAM AISPSGISPS LGSKLSPGSP EAVTLAQWIS QSYSHHLGSE LLTIDSLGSD 720 DSVLKLLWDH QDAILCCSLK PQPVFMFANQ AGLDMLETTL VALQDITLEK IFDESGRKAI 780 CSDFAKLMQQ GFACLPSGIC VSTMGRHVSY EQAVAWKVFA ASEENNNNLH CLAFSFVNWS 840 FV

Sequence ? help Back to Top

Protein Sequence Length: 842 aa Download sequence Send to blast

MEMAVANHRE RSSDSMNRHL DSSGKYVRYT AEQVEALERV YAECPKPSSL RRQQLIRECS  60
ILANIEPKQI KVWFQNRRCR DKQRKEASRL QSVNRKLSAM NKLLMEENDR LQKQVSQLVC  120
ENGYMKQQLT TVVNDPSCES VVTTPQHSLR DANSPAGLLS IAEETLAEFL SKATGTAVDW  180
VQMPGMKPGP DSVGIFAISQ RCNGVAARAC GLVSLEPMKI AEILKDRPSW FRDCRSLEVF  240
TMFPAGNGGT IELVYMQTYA PTTLAPARDF WTLRYTTSLD NGSFVVCERS LSGSGAGPNA  300
ASASQFVRAE MLSSGYLIRP CDGGGSIIHI VDHLNLEAWS VPDVLRPLYE SSKVVAQKMT  360
ISALRYIRQL AQESNGEVVY GLGRQPAVLR TFSQRLSRGF NDAVNGFGDD GWSTMHCDGA  420
EDIIVAINST KHLNNISNSL SFLGGVLCAK ASMLLQNVPP AVLIRFLREH RSEWADFNVD  480
AYSAATLKAG SFAYPGMRPT RFTGSQIIMP LGHTIEHEEM LEVVRLEGHS LAQEDAFMSR  540
DVHLLQICTG IDENAVGACS ELIFAPINEM FPDDAPLVPS GFRVIPVDAK TGDVQDLLTA  600
NHRTLDLTSS LEVGPSPENA SGNSFSSSSS RCILTIAFQF PFENNLQENV AGMACQYVRS  660
VISSVQRVAM AISPSGISPS LGSKLSPGSP EAVTLAQWIS QSYSHHLGSE LLTIDSLGSD  720
DSVLKLLWDH QDAILCCSLK PQPVFMFANQ AGLDMLETTL VALQDITLEK IFDESGRKAI  780
CSDFAKLMQQ GFACLPSGIC VSTMGRHVSY EQAVAWKVFA ASEENNNNLH CLAFSFVNWS  840
FV

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.7238	0.0	bud\| flower\| leaf\| root\| seed\| silique

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145359496	0.0
Genevisible	247589_at	0.0
Expression Atlas	AT5G60690	-
AtGenExpress	AT5G60690	-
ATTED-II	AT5G60690	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed at the earliest stages and throughout LSM initiation and development. In embryo development, expressed at the heart stage until the 'walking stick' stage in the adaxial portion of the cotyledon primordia, the shoot apical meristem (SAM) and the vascular precursor cells of the hypocotyl and root. In developing flowers, expressed first at stage 1 in the center of L3 layer and then expands to the center of L2 and L1 layers. Expressed in the center of flower meristem through stages 4 and 5. At stage 6, expressed in the adaxial side of the carpel primordia and then on the adaxial carpel face. {ECO:0000269\|PubMed:11169198}.
Uniprot	TISSUE SPECIFICITY: Expressed in the interfascicular regions of stem and vascular bundles of young roots and leaves. {ECO:0000269\|PubMed:10559440}.

Functional Description ? help Back to Top
Source	Description
TAIR	REVOLUTA regulates meristem initiation at lateral positions. a member of a small homeodomain-leucine zipper family. Has overlapping functions with PHAVOLUTA and PHABULOSA.
UniProt	Probable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269\|PubMed:10559440, ECO:0000269\|PubMed:11169198, ECO:0000269\|PubMed:11402186, ECO:0000269\|PubMed:15111711, ECO:0000269\|PubMed:15598805, ECO:0000269\|PubMed:20807212, ECO:0000269\|PubMed:22781836, ECO:0000269\|PubMed:7555701}.

Function -- GeneRIF ? help Back to Top
Class III HD-Zip AND KANADI genes required for root development [PMID: 15286295] 26S proteasome RPN2a gene and the REVOLUTA regulated inflorescence and floral meristem functions. [PMID: 20797995] Dof5.1 protein regulates leaf adaxial-abaxial polarity by controlling REV expression. [PMID: 20807212] MEKHLA is a negative regulatory domain that prevents dimerization of REV. [PMID: 21357492] REV acts upstream of auxin biosynthesis and affects directly the expression of several class II HD-ZIP transcription factors that have been shown to act in the shade-avoidance response pathway. [PMID: 22578006] HD-ZIPIII and KANADI regulate tissue-specific transcription factors involved in subsidiary developmental decisions, nearly all major hormone pathways, and new actors (such as indeterminate domain4) in the ad/abaxial regulatory network. [PMID: 24076978] REV acts as a redox-sensitive transcription factor, and directly and positively regulates the expression of WRKY53, a master regulator of age-induced leaf senescence. [PMID: 25395454] BLH6 and KNAT7 bind to the REV promoter and repress REV expression. [PMID: 25490916]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT5G60690.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269\|PubMed:15111711, ECO:0000269\|PubMed:17237362, ECO:0000269\|PubMed:20807212}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G55580 (A), AT4G37750 (A)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT2G45450(A)

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Plants display strongly reduced auxin polar transport in inflorescence stems and hypocotyls. This phenotype is probably due to altered cell differentiation and morphology. {ECO:0000269\|PubMed:11402186}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT5G60690

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF188994	0.0	AF188994.1 Arabidopsis thaliana homeodomain-leucine zipper protein interfascicular fiberless 1 (IFL1) mRNA, complete cds.
GenBank	AF233592	0.0	AF233592.1 Arabidopsis thaliana REVOLUTA mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_200877.1	0.0	Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein
Swissprot	Q9SE43	0.0	REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBL	A0A178UL04	0.0	A0A178UL04_ARATH; REV
STRING	AT5G60690.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM4779	27	54
Representative plant	OGRP651	16	71

Link Out ? help Back to Top
Phytozome	AT5G60690.1
Entrez Gene	836190
iHOP	AT5G60690
wikigenes	AT5G60690

Publications ? help Back to Top
Chen Q, et al. The Arabidopsis FILAMENTOUS FLOWER gene is required for flower formation. Development, 1999. 126(12): p. 2715-26 [PMID:10331982] Zhong R,Ye ZH IFL1, a gene regulating interfascicular fiber differentiation in Arabidopsis, encodes a homeodomain-leucine zipper protein. Plant Cell, 1999. 11(11): p. 2139-52 [PMID:10559440] Ratcliffe OJ,Riechmann JL,Zhang JZ INTERFASCICULAR FIBERLESS1 is the same gene as REVOLUTA. Plant Cell, 2000. 12(3): p. 315-7 [PMID:10715319] Koltai H,Bird DM High throughput cellular localization of specific plant mRNAs by liquid-phase in situ reverse transcription-polymerase chain reaction of tissue sections. Plant Physiol., 2000. 123(4): p. 1203-12 [PMID:10938339] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Otsuga D,DeGuzman B,Prigge MJ,Drews GN,Clark SE REVOLUTA regulates meristem initiation at lateral positions. Plant J., 2001. 25(2): p. 223-36 [PMID:11169198] Zhong R,Ye ZH Alteration of auxin polar transport in the Arabidopsis ifl1 mutants. Plant Physiol., 2001. 126(2): p. 549-63 [PMID:11402186] Baima S, et al. The arabidopsis ATHB-8 HD-zip protein acts as a differentiation-promoting transcription factor of the vascular meristems. Plant Physiol., 2001. 126(2): p. 643-55 [PMID:11402194] Ohashi-Ito K,Demura T,Fukuda H Promotion of transcript accumulation of novel Zinnia immature xylem-specific HD-Zip III homeobox genes by brassinosteroids. Plant Cell Physiol., 2002. 43(10): p. 1146-53 [PMID:12407194] Greb T, et al. Molecular analysis of the LATERAL SUPPRESSOR gene in Arabidopsis reveals a conserved control mechanism for axillary meristem formation. Genes Dev., 2003. 17(9): p. 1175-87 [PMID:12730136] Emery JF, et al. Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI genes. Curr. Biol., 2003. 13(20): p. 1768-74 [PMID:14561401] Zhong R,Ye ZH Amphivasal vascular bundle 1, a gain-of-function mutation of the IFL1/REV gene, is associated with alterations in the polarity of leaves, stems and carpels. Plant Cell Physiol., 2004. 45(4): p. 369-85 [PMID:15111711] Hawker NP,Bowman JL Roles for Class III HD-Zip and KANADI genes in Arabidopsis root development. Plant Physiol., 2004. 135(4): p. 2261-70 [PMID:15286295] Yu L,Yu X,Shen R,He Y HYL1 gene maintains venation and polarity of leaves. Planta, 2005. 221(2): p. 231-42 [PMID:15580355] Prigge MJ, et al. Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development. Plant Cell, 2005. 17(1): p. 61-76 [PMID:15598805] Williams L,Grigg SP,Xie M,Christensen S,Fletcher JC Regulation of Arabidopsis shoot apical meristem and lateral organ formation by microRNA miR166g and its AtHD-ZIP target genes. Development, 2005. 132(16): p. 3657-68 [PMID:16033795] Schmitz G,Theres K Shoot and inflorescence branching. Curr. Opin. Plant Biol., 2005. 8(5): p. 506-11 [PMID:16054429] Lee JY, et al. Transcriptional and posttranscriptional regulation of transcription factor expression in Arabidopsis roots. Proc. Natl. Acad. Sci. U.S.A., 2006. 103(15): p. 6055-60 [PMID:16581911] Prigge MJ,Clark SE Evolution of the class III HD-Zip gene family in land plants. Evol. Dev., 2006 Jul-Aug. 8(4): p. 350-61 [PMID:16805899] Huang W, et al. The proteolytic function of the Arabidopsis 26S proteasome is required for specifying leaf adaxial identity. Plant Cell, 2006. 18(10): p. 2479-92 [PMID:17028202] Zhou GK,Kubo M,Zhong R,Demura T,Ye ZH Overexpression of miR165 affects apical meristem formation, organ polarity establishment and vascular development in Arabidopsis. Plant Cell Physiol., 2007. 48(3): p. 391-404 [PMID:17237362] Chandler JW,Cole M,Flier A,Grewe B,Werr W The AP2 transcription factors DORNROSCHEN and DORNROSCHEN-LIKE redundantly control Arabidopsis embryo patterning via interaction with PHAVOLUTA. Development, 2007. 134(9): p. 1653-62 [PMID:17376809] Fu Y, et al. Genetic interactions between leaf polarity-controlling genes and ASYMMETRIC LEAVES1 and 2 in Arabidopsis leaf patterning. Plant Cell Physiol., 2007. 48(5): p. 724-35 [PMID:17395603] Ehrenreich IM,Stafford PA,Purugganan MD The genetic architecture of shoot branching in Arabidopsis thaliana: a comparative assessment of candidate gene associations vs. quantitative trait locus mapping. Genetics, 2007. 176(2): p. 1223-36 [PMID:17435248] Wenkel S,Emery J,Hou BH,Evans MM,Barton MK A feedback regulatory module formed by LITTLE ZIPPER and HD-ZIPIII genes. Plant Cell, 2007. 19(11): p. 3379-90 [PMID:18055602] Azhakanandam S,Nole-Wilson S,Bao F,Franks RG SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development. Plant Physiol., 2008. 146(3): p. 1165-81 [PMID:18184731] Jes Two translesion synthesis DNA polymerase genes, AtPOLH and AtREV1, are involved in development and UV light resistance in Arabidopsis. J. Plant Physiol., 2008. 165(15): p. 1582-91 [PMID:18339443] Kim YS, et al. HD-ZIP III activity is modulated by competitive inhibitors via a feedback loop in Arabidopsis shoot apical meristem development. Plant Cell, 2008. 20(4): p. 920-33 [PMID:18408069] Ochando I,González-Reig S,Ripoll JJ,Vera A,Martínez-Laborda A Alteration of the shoot radial pattern in Arabidopsis thaliana by a gain-of-function allele of the class III HD-Zip gene INCURVATA4. Int. J. Dev. Biol., 2008. 52(7): p. 953-61 [PMID:18956325] Kelley DR,Skinner DJ,Gasser CS Roles of polarity determinants in ovule development. Plant J., 2009. 57(6): p. 1054-64 [PMID:19054366] Zhong R,Ye ZH Regulation of HD-ZIP III Genes by MicroRNA 165. Plant Signal Behav, 2007. 2(5): p. 351-3 [PMID:19704656] Yao X, et al. Two types of cis-acting elements control the abaxial epidermis-specific transcription of the MIR165a and MIR166a genes. FEBS Lett., 2009. 583(22): p. 3711-7 [PMID:19879265] Nole-Wilson S,Azhakanandam S,Franks RG Polar auxin transport together with aintegumenta and revoluta coordinate early Arabidopsis gynoecium development. Dev. Biol., 2010. 346(2): p. 181-95 [PMID:20654611] Zhang Z, et al. Convergence of the 26S proteasome and the REVOLUTA pathways in regulating inflorescence and floral meristem functions in Arabidopsis. J. Exp. Bot., 2011. 62(1): p. 359-69 [PMID:20797995] Kim HS, et al. The DOF transcription factor Dof5.1 influences leaf axial patterning by promoting Revoluta transcription in Arabidopsis. Plant J., 2010. 64(3): p. 524-35 [PMID:20807212] Robischon M,Du J,Miura E,Groover A The Populus class III HD ZIP, popREVOLUTA, influences cambium initiation and patterning of woody stems. Plant Physiol., 2011. 155(3): p. 1214-25 [PMID:21205615] Brady SM, et al. A stele-enriched gene regulatory network in the Arabidopsis root. Mol. Syst. Biol., 2011. 7: p. 459 [PMID:21245844] Magnani E,Barton MK A per-ARNT-sim-like sensor domain uniquely regulates the activity of the homeodomain leucine zipper transcription factor REVOLUTA in Arabidopsis. Plant Cell, 2011. 23(2): p. 567-82 [PMID:21357492] Yamaguchi N,Yamaguchi A,Abe M,Wagner D,Komeda Y LEAFY controls Arabidopsis pedicel length and orientation by affecting adaxial-abaxial cell fate. Plant J., 2012. 69(5): p. 844-56 [PMID:22050454] Brandt R, et al. Genome-wide binding-site analysis of REVOLUTA reveals a link between leaf patterning and light-mediated growth responses. Plant J., 2012. 72(1): p. 31-42 [PMID:22578006] Brandt R, et al. Control of stem cell homeostasis via interlocking microRNA and microProtein feedback loops. Mech. Dev., 2013. 130(1): p. 25-33 [PMID:22781836] Bou-Torrent J, et al. ATHB4 and HAT3, two class II HD-ZIP transcription factors, control leaf development in Arabidopsis. Plant Signal Behav, 2012. 7(11): p. 1382-7 [PMID:22918502] Nakata M,Okada K The three-domain model: a new model for the early development of leaves in Arabidopsis thaliana. Plant Signal Behav, 2012. 7(11): p. 1423-7 [PMID:22951404] Meinke DW A survey of dominant mutations in Arabidopsis thaliana. Trends Plant Sci., 2013. 18(2): p. 84-91 [PMID:22995285] Etchells JP, et al. A role for BELLRINGER in cell wall development is supported by loss-of-function phenotypes. BMC Plant Biol., 2012. 12: p. 212 [PMID:23148846] Turchi L, et al. Arabidopsis HD-Zip II transcription factors control apical embryo development and meristem function. Development, 2013. 140(10): p. 2118-29 [PMID:23578926] Liu Z, et al. GUS activity for miR165a/166b, REV, and WUS/CLV3 in in vitro direct Arabidopsis thaliana shoot regeneration. Protoplasma, 2013. 250(5): p. 1213-8 [PMID:23645346] Lian H,Li X,Liu Z,He Y HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis. J. Exp. Bot., 2013. 64(11): p. 3397-410 [PMID:23918970] Reinhart BJ, et al. Establishing a framework for the Ad/abaxial regulatory network of Arabidopsis: ascertaining targets of class III homeodomain leucine zipper and KANADI regulation. Plant Cell, 2013. 25(9): p. 3228-49 [PMID:24076978] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Baima S, et al. Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module. Mol Plant, 2014. 7(6): p. 1006-1025 [PMID:24777988] Floyd SK, et al. Origin of a novel regulatory module by duplication and degeneration of an ancient plant transcription factor. Mol. Phylogenet. Evol., 2014. 81: p. 159-73 [PMID:25263420] Xie Y, et al. REVOLUTA and WRKY53 connect early and late leaf development in Arabidopsis. Development, 2014. 141(24): p. 4772-83 [PMID:25395454] Liu Y, et al. BEL1-LIKE HOMEODOMAIN6 and KNOTTED ARABIDOPSIS THALIANA7 interact and regulate secondary cell wall formation via repression of REVOLUTA. Plant Cell, 2014. 26(12): p. 4843-61 [PMID:25490916] Jia X, et al. Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic. Plant Sci., 2015. 233: p. 11-21 [PMID:25711809] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Roodbarkelari F,Du F,Truernit E,Laux T ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response. BMC Biol., 2015. 13: p. 74 [PMID:26358077] Shi B, et al. Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis. PLoS Genet., 2016. 12(7): p. e1006168 [PMID:27398935] Talbert PB,Adler HT,Parks DW,Comai L The REVOLUTA gene is necessary for apical meristem development and for limiting cell divisions in the leaves and stems of Arabidopsis thaliana. Development, 1995. 121(9): p. 2723-35 [PMID:7555701] Zhong R,Taylor JJ,Ye ZH Disruption of interfascicular fiber differentiation in an Arabidopsis mutant. Plant Cell, 1997. 9(12): p. 2159-70 [PMID:9437861]