PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Solyc01g090340.2.1
Common NameGAME9
Organism
Solanum lycopersicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
Family ERF
Protein Properties Length: 220aa    MW: 24464.4 Da    PI: 5.1512
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Solyc01g090340.2.1genomeITAGView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP246.11.2e-1482132255
                 AP2   2 gykGVrwdkkrgrWvAeIrdpseng.krkrfslgkfgtaeeAakaaiaarkkleg 55 
                         ++ GVr++  +g + AeIrdp   + + +r +lg++ ++ +Aa a+++a+ k++g
  Solyc01g090340.2.1  82 RFIGVRRRQ-WGTFSAEIRDP---NrRGARLWLGTYESPRDAALAYDQAAYKIRG 132
                         578***887.**********9...4334*************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000187.61E-2482142No hitNo description
Gene3DG3DSA:3.30.730.105.7E-2782141IPR001471AP2/ERF domain
PROSITE profilePS5103220.99582140IPR001471AP2/ERF domain
PfamPF008479.8E-1082132IPR001471AP2/ERF domain
SMARTSM003805.5E-2582146IPR001471AP2/ERF domain
PRINTSPR003672.7E-98394IPR001471AP2/ERF domain
SuperFamilySSF541712.62E-1983141IPR016177DNA-binding domain
PRINTSPR003672.7E-9122142IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 220 aa     Download sequence    Send to blast
MSIVIDDDEI FSLPSLDELE SITHLLYDDD SDFFETLSPM SLDVTTLLPN IPTSNSIESP  60
VTPEETKEPS VACEDAPQDW RRFIGVRRRQ WGTFSAEIRD PNRRGARLWL GTYESPRDAA  120
LAYDQAAYKI RGTKVRLNFP DLIGSDVPMP PRVTARRRTR SRSRSPEPLT TSSSSSSSSS  180
SSSSSSSENG TKKRKIDLIN SIAKSKLLCG MDLQMLIQM*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2gcc_A4e-2281145468ATERF1
3gcc_A4e-2281145468ATERF1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Les.94590.0leaf
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots and at low levels in buds and leaves. Not expressed in cell culture. {ECO:0000269|PubMed:7756828}.
Functional Description ? help Back to Top
Source Description
UniProtActs as a transcriptional activator and may be involved in disease resistance pathways. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways mediated by ethylene, that seems to depend on a protein kinase cascade, and to be influenced by methyl-jasmonate. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:10792818, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
Function -- GeneRIF ? help Back to Top
  1. GLYCOALKALOID METABOLISM 9 (GAME9) controls steroid glycoalkaloid biosynthesis and upstream mevalonate pathway genes.
    [PMID: 26876023]
  2. master transcriptional regulator of defense-related steroidal glycoalkaloids
    [PMID: 29569783]
  3. regulates tobacco quinolinate phosphoribosyl transferase(QPT) gene in tomato though it does not regulate tomato QPT gene
    [PMID: 30478481]
Cis-element ? help Back to Top
SourceLink
PlantRegMapSolyc01g090340.2.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by ethephon (ethylene-releasing compound) in buds and to a lower extent in leaves. Strongly induced by cycloheximide and mechanical stimuli. Wounding leads to a both local and systemic expression, independently of ethylene, and through a de-novo-protein-synthesis-independent regulation. Wound induction is reduced by methyl-jasmonate. Induction by purified xylanase from Trichoderma viride (TvX) and another elicitor from Phytophthora infestans (PiE), that appears to be mediated by both protein kinases and protein phosphatases. {ECO:0000269|PubMed:10652129, ECO:0000269|PubMed:12090623, ECO:0000269|PubMed:7756828, ECO:0000269|Ref.2}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_004229751.11e-157ethylene-responsive transcription factor 1
SwissprotQ404792e-32ERF2_TOBAC; Ethylene-responsive transcription factor 2
TrEMBLM1CGB01e-118M1CGB0_SOLTU; Uncharacterized protein
STRINGSolyc01g090340.2.11e-156(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA21241165
Representative plantOGRP6161718
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G44840.17e-30ethylene-responsive element binding factor 13
Publications ? help Back to Top
  1. Wang Y,van der Hoeven RS,Nielsen R,Mueller LA,Tanksley SD
    Characteristics of the tomato nuclear genome as determined by sequencing undermethylated EcoRI digested fragments.
    Theor. Appl. Genet., 2005. 112(1): p. 72-84
    [PMID:16208505]
  2. Nakano T,Nishiuchi T,Suzuki K,Fujimura T,Shinshi H
    Studies on transcriptional regulation of endogenous genes by ERF2 transcription factor in tobacco cells.
    Plant Cell Physiol., 2006. 47(4): p. 554-8
    [PMID:16452120]
  3. C
    GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway.
    Nat Commun, 2016. 7: p. 10654
    [PMID:26876023]
  4. Nakayasu M, et al.
    JRE4 is a master transcriptional regulator of defense-related steroidal glycoalkaloids in tomato.
    Plant J., 2018. 94(6): p. 975-990
    [PMID:29569783]
  5. Shoji T,Hashimoto T
    Expression of a tobacco nicotine biosynthesis gene depends on the JRE4 transcription factor in heterogenous tomato.
    J. Plant Res., 2019. 132(2): p. 173-180
    [PMID:30478481]