PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT2G44840.1

Common Name

ATERF13, EREBP, ERF099, ERF13, ERF-13, T13E15.15

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

ERF

Protein Properties

Length: 226aa MW: 25353.1 Da PI: 6.7937

Description

ethylene-responsive element binding factor 13

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT2G44840.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	62.3	1.1e-19	91	141	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 +y+GVr+++ +g+++AeIrdp++ng +r++lg++ t+e+Aa a+++a+ +l+g AT2G44840.1 91 QYRGVRRRP-WGKFAAEIRDPKKNG--ARVWLGTYETPEDAAVAYDRAAFQLRG 141 59*****.*******9998..***********************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51032	24.105	91	149	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	2.3E-32	91	150	IPR001471	AP2/ERF domain
CDD	cd00018	2.36E-31	91	151	No hit	No description
SuperFamily	SSF54171	2.75E-23	91	150	IPR016177	DNA-binding domain
SMART	SM00380	1.4E-37	91	155	IPR001471	AP2/ERF domain
Pfam	PF00847	3.3E-13	92	141	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.8E-13	92	103	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.8E-13	131	151	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0006952	Biological Process	defense response
GO:0009873	Biological Process	ethylene-activated signaling pathway
GO:0010200	Biological Process	response to chitin
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0000293	anatomy	guard cell
PO:0009005	anatomy	root
PO:0009009	anatomy	plant embryo
PO:0009025	anatomy	vascular leaf
PO:0009029	anatomy	stamen
PO:0009030	anatomy	carpel
PO:0009052	anatomy	flower pedicel
PO:0020030	anatomy	cotyledon
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0001185	developmental stage	plant embryo globular stage
PO:0007064	developmental stage	LP.12 twelve leaves visible stage
PO:0007095	developmental stage	LP.08 eight leaves visible stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007103	developmental stage	LP.10 ten leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007123	developmental stage	LP.06 six leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 226 aa Download sequence Send to blast
MSSSDSVNNG VNSRMYFRNP SFSNVILNDN WSDLPLSVDD SQDMAIYNTL RDAVSSGWTP 60 SVPPVTSPAE ENKPPATKAS GSHAPRQKGM QYRGVRRRPW GKFAAEIRDP KKNGARVWLG 120 TYETPEDAAV AYDRAAFQLR GSKAKLNFPH LIGSCKYEPV RIRPRRRSPE PSVSDQLTSE 180 QKRESHVDDG ESSLVVPELD FTVDQFYFDG SLLMDQSECS YSDNRI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2gcc_A	9e-32	88	154	2	68	ATERF1
3gcc_A	9e-32	88	154	2	68	ATERF1
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.29014	0.0	leaf\| root\| seed

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30689849	0.0
Genevisible	266821_at	0.0
Expression Atlas	AT2G44840	-
AtGenExpress	AT2G44840	-
ATTED-II	AT2G44840	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Ubiquitously expressed after ethylene treatment. {ECO:0000269\|PubMed:11950980}.

Functional Description ? help Back to Top
Source	Description
TAIR	encodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5.
UniProt	Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways. {ECO:0000269\|PubMed:11950980}.

Function -- GeneRIF ? help Back to Top
Data show that AtERF13 (At2g44840), one of the CEBFs, confers ABA hypersensitivity. [PMID: 21162722]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00311	DAP	27203113	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT2G44840.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Strongly induced by wounding. Induced by Pseudomonas syringae tomato (both virulent and avirulent avrRpt2 strains), independently of PAD4. Also induced by methyl jasmonate (MeJA) independently of JAR1, but seems to not be affected by ethylene. Induction by salicylic acid (SA) is controlled by growth and/or developmental conditions, and seems to be more efficient and independent of PAD4 in older plants. {ECO:0000269\|PubMed:11950980, ECO:0000269\|PubMed:12068110}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G04370 (A)

Regulation -- Hormone ? help Back to Top
Source	Hormone
AHD	ethylene

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT2G44840

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC002388	0.0	AC002388.3 Arabidopsis thaliana chromosome 2 clone T13E15 map m336, complete sequence.
GenBank	AF325089	0.0	AF325089.1 Arabidopsis thaliana putative ethylene response element binding protein (EREBP) (At2g44840) mRNA, complete cds.
GenBank	AF370540	0.0	AF370540.1 Arabidopsis thaliana putative ethylene response element binding protein; EREBP (At2g44840; T13E15.15) mRNA, complete cds.
GenBank	AY072471	0.0	AY072471.1 Arabidopsis thaliana putative ethylene response element binding protein (EREBP) (At2g44840; T13E15.15) mRNA, complete cds.
GenBank	CP002685	0.0	CP002685.1 Arabidopsis thaliana chromosome 2, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_182011.1	1e-168	ethylene-responsive element binding factor 13
Swissprot	Q8L9K1	1e-169	ERF99_ARATH; Ethylene-responsive transcription factor 13
TrEMBL	A0A178W1M8	1e-166	A0A178W1M8_ARATH; ERF13
STRING	AT2G44840.1	1e-167	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650
Representative plant	OGRP6	16	1718

Link Out ? help Back to Top
Phytozome	AT2G44840.1
Entrez Gene	819093
iHOP	AT2G44840
wikigenes	AT2G44840

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] O Identification of Arabidopsis ethylene-responsive element binding factors with distinct induction kinetics after pathogen infection. Plant Physiol., 2002. 128(4): p. 1313-22 [PMID:11950980] Cheong YH, et al. Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis. Plant Physiol., 2002. 129(2): p. 661-77 [PMID:12068110] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Koroleva OA,Tomlinson ML,Leader D,Shaw P,Doonan JH High-throughput protein localization in Arabidopsis using Agrobacterium-mediated transient expression of GFP-ORF fusions. Plant J., 2005. 41(1): p. 162-74 [PMID:15610358] Babula D, et al. Genes involved in biosynthesis and signalisation of ethylene in Brassica oleracea and Arabidopsis thaliana: identification and genome comparative mapping of specific gene homologues. Theor. Appl. Genet., 2006. 112(3): p. 410-20 [PMID:16311726] Nakano T,Suzuki K,Fujimura T,Shinshi H Genome-wide analysis of the ERF gene family in Arabidopsis and rice. Plant Physiol., 2006. 140(2): p. 411-32 [PMID:16407444] Libault M,Wan J,Czechowski T,Udvardi M,Stacey G Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor. Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11 [PMID:17722694] Welsch R,Maass D,Voegel T,Dellapenna D,Beyer P Transcription factor RAP2.2 and its interacting partner SINAT2: stable elements in the carotenogenesis of Arabidopsis leaves. Plant Physiol., 2007. 145(3): p. 1073-85 [PMID:17873090] Maimbo M,Ohnishi K,Hikichi Y,Yoshioka H,Kiba A Induction of a small heat shock protein and its functional roles in Nicotiana plants in the defense response against Ralstonia solanacearum. Plant Physiol., 2007. 145(4): p. 1588-99 [PMID:17965181] Lee SJ,Park JH,Lee MH,Yu JH,Kim SY Isolation and functional characterization of CE1 binding proteins. BMC Plant Biol., 2010. 10: p. 277 [PMID:21162722] Sogabe Y, et al. Visualization of wounding-induced root-to-shoot communication in Arabidopsis. Plant Signal Behav, 2011. 6(7): p. 1037-9 [PMID:21617378] Tiwari SB, et al. The EDLL motif: a potent plant transcriptional activation domain from AP2/ERF transcription factors. Plant J., 2012. 70(5): p. 855-65 [PMID:22321262] Srivastava S, et al. Gene expression profiling through microarray analysis in Arabidopsis thaliana colonized by Pseudomonas putida MTCC5279, a plant growth promoting rhizobacterium. Plant Signal Behav, 2012. 7(2): p. 235-45 [PMID:22353860] Schweizer F,Bodenhausen N,Lassueur S,Masclaux FG,Reymond P Differential Contribution of Transcription Factors to Arabidopsis thaliana Defense Against Spodoptera littoralis. Front Plant Sci, 2013. 4: p. 13 [PMID:23382734] Kang NY,Lee HW,Kim J The AP2/EREBP gene PUCHI Co-Acts with LBD16/ASL18 and LBD18/ASL20 downstream of ARF7 and ARF19 to regulate lateral root development in Arabidopsis. Plant Cell Physiol., 2013. 54(8): p. 1326-34 [PMID:23749813] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Jin J, et al. An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors. Mol. Biol. Evol., 2015. 32(7): p. 1767-73 [PMID:25750178] Nemoto K,Takemori N,Seki M,Shinozaki K,Sawasaki T Members of the Plant CRK Superfamily Are Capable of Trans- and Autophosphorylation of Tyrosine Residues. J. Biol. Chem., 2015. 290(27): p. 16665-77 [PMID:25969537] Riechmann JL,Meyerowitz EM The AP2/EREBP family of plant transcription factors. Biol. Chem., 1998. 379(6): p. 633-46 [PMID:9687012]