PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676789458
Organism
Sisymbrium irio
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family E2F/DP
Protein Properties Length: 307aa    MW: 34741.5 Da    PI: 9.1015
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676789458genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.91.5e-221176171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rkeksL++l ++fl+l+++ + + + l+++a +L    v  +rRRiYD++N+Le+++l++++ kn+++wkg
  676789458 11 RKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGKL---GV--ERRRIYDVVNILESIGLVARRGKNQYSWKG 76
               79*****************999************...**..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.109.5E-24777IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.15E-151074IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-261176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.3E-181276IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 307 aa     Download sequence    Send to blast
MDSLGRQSYS RKEKSLGVLV SNFLRLYNRD DVDLIGLDDA AGKLGVERRR IYDVVNILES  60
IGLVARRGKN QYSWKGFGQV PRVLTDLKEE GMREKFGIIP CVTNLEMDLY DKVREEPLKL  120
SPDDHENSPS PKLDSKKEKS LWVLAQNFVK LFLCSDTHIP ETKKPAYRWL GAKAISEGKF  180
LAAPTSPCDR NESKKRVFGT EITNFNTKRA KTDCSKDLKH YENQNAGSGI KQEQCDLKPA  240
VKSFVGPLSP ADTSKKTDVG KNNNQSIEVL ENLSSTHKLQ YCNQELIGLL GHYTETWTAW  300
HAEFGRK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-19101713187Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00511DAPTransfer from AT5G14960Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMap676789458
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013726153.10.0E2F transcription factor-like E2FD isoform X1
SwissprotQ9LFQ91e-129E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLA0A3P6CXP10.0A0A3P6CXP1_BRAOL; Uncharacterized protein
STRINGBo2g012280.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G14960.11e-131DP-E2F-like 2