PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID 676731370
Organism
Sisymbrium irio
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Sisymbrieae; Sisymbrium
Family E2F/DP
Protein Properties Length: 376aa    MW: 42861.4 Da    PI: 8.8699
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
676731370genomeVEGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.73.9e-232287171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rkeksL++l ++fl+l+++ +++ + l+++a +L    v  +rRRiYD++N+Le++++++k++kn+++wkg
  676731370 22 RKEKSLGVLVSNFLRLYNRDDADLIGLDDAAAKL---GV--ERRRIYDVVNILESIGVVAKRAKNQYSWKG 87
               79********************************...**..****************************98 PP
2E2F_TDP82.14.5e-26148228171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                +ke+sL+ll+q+f+k++ +s+++ +tl+ +ak+L+s+     ++++k+RR+YDi+NV+++++liek     ++k++++w g
  676731370 148 KKERSLWLLSQNFVKMFLCSDDDLITLDRAAKALLSDsqdpmHMRTKVRRLYDIANVFSSMDLIEKthlpgTKKPAYKWLG 228
                699****************************************************************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.5E-241988IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.93E-152185IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.4E-262287IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.5E-192387IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.5E-21144230IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.8E-30148228IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.6E-19149228IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.0E-12151229IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 376 aa     Download sequence    Send to blast
MTSRMIVCED YAEALGLQSY SRKEKSLGVL VSNFLRLYNR DDADLIGLDD AAAKLGVERR  60
RIYDVVNILE SIGVVAKRAK NQYSWKGFLE IPRSLDELKE EGMREGFGIS TSICSNSHKV  120
SHDDEREDSI CLTADDHDNS ALSKMDHKKE RSLWLLSQNF VKMFLCSDDD LITLDRAAKA  180
LLSDSQDPMH MRTKVRRLYD IANVFSSMDL IEKTHLPGTK KPAYKWLGSK SITEKGSSLF  240
NSNEPKKRVF GTEITNVRTK RNKTDCSSNY KQIGYQKYDE ENTEQETKPA AKSYVFGPFS  300
PAGASNKKKN NVNSPRLQDL EALASTYKPQ YCNHGNNHTQ NRYRSIKINN PAFLIPFDIS  360
QTKFAVANVA EFWLWF
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-32212163224Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMap676731370
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020885968.10.0E2F transcription factor-like E2FF
SwissprotQ8RWL00.0E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A0D3CNF00.0A0A0D3CNF0_BRAOL; Uncharacterized protein
TrEMBLA0A3P6ERE50.0A0A3P6ERE5_BRAOL; Uncharacterized protein
STRINGBostr.1460s0076.1.p0.0(Boechera stricta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-173DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]