PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016499262.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 659aa    MW: 71938.9 Da    PI: 5.4963
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016499262.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.22.3e-11487532454
                     HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
             HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                     +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ +I++L
  XP_016499262.1 487 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAFINEL 532
                     799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.2E-5474258IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.539483532IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.64E-14486537No hitNo description
SuperFamilySSF474594.71E-17486555IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000106.5E-9487532IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.1E-17487553IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.0E-15489538IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 659 aa     Download sequence    Send to blast
MTDYRIPTMT NIWSNTTSDD NMMEAFLSSD PSSFWPGTTT TPTPRSSVSP APAPVTGIAG  60
DPLKSMPYFN QESLQQRLQT LIDGARKGWT YAIFWQSSVV DFASPSVLGW GDGYYKGEED  120
KNKRKTASFS PDFITEQAHR KKVLRELNSL ISGTQTGGEN DAVDEEVTDT EWFFLISMTQ  180
SFVNGSGLPG LAMYSSSPIW VTGTERLAVS HCERARQAQG FGLQTIVCIP SANGVVELGS  240
TELIFQTADL MNKVKVLFNF NIDMGATTGS GSGSCAIQAE PDPSALWLTD PASSVVEVKD  300
SSNTVPSRNT SKQLVFGNEN SENGNQNSQQ TQGFFTRELN FSEYGFDGSN TRYGNGNANS  360
SRSCKPESGE ILNFGDSTKR SACSANGSLF SGQSQFGPGP AEENKNKNKK RSPASRGSND  420
EGILSFVSGV ILPSSNTGKS GGGGDSDQSD LEASVVKEAD SSRVVDPEKK PRKRGRKPAN  480
GREEPLNHVE AERQRREKLN QRFYALRAVV PNVSKMDKAS LLGDAIAFIN ELKSKVQNSD  540
SDKEDLRNQI ESLRNELANK GSNYTGPPPS NQELKIVDMD IDVKVIGWDA MIRIQSNKKN  600
HPAARLMTAL MELDLDVHHA SVSVVNELMI QQATVKMGSR LYTQEQLRIS LTSRIAESR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A6e-65672612195Transcription factor MYC3
4rqw_B6e-65672612195Transcription factor MYC3
4rs9_A6e-65672612195Transcription factor MYC3
4yz6_A6e-65672612195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1468476KKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in a number of promoters of jasmonate-induced genes (PubMed:15231736). Transcription activator involved in the transcriptional regulation of terpene biosynthesis in glandular trichomes (PubMed:24884371, PubMed:30518626). Binds to the promoter of the linalool synthase TPS5 and promotes TPS5 gene transactivation (PubMed:24884371). Acts synergistically with EOT1 in the transactivation of TPS5 (PubMed:24884371). Involved in type VI glandular trichome development (PubMed:30518626). Involved in the activation of terpene synthases required for volatile mono- and sesquiterpenes synthesis by the glandular cells of type VI trichomes (PubMed:30518626). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371, ECO:0000269|PubMed:30518626}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate and wounding. {ECO:0000269|PubMed:15231736}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankGQ8591600.0GQ859160.1 Nicotiana tabacum MYC2a transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001312938.10.0transcription factor MYC2-like
SwissprotA0A060KY900.0MYC1_SOLLC; Transcription factor MYC1
TrEMBLA0A1S4CDG70.0A0A1S4CDG7_TOBAC; transcription factor MYC2-like
STRINGXP_009800420.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.10.0bHLH family protein
Publications ? help Back to Top
  1. Todd AT,Liu E,Polvi SL,Pammett RT,Page JE
    A functional genomics screen identifies diverse transcription factors that regulate alkaloid biosynthesis in Nicotiana benthamiana.
    Plant J., 2010. 62(4): p. 589-600
    [PMID:20202168]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Spyropoulou EA,Haring MA,Schuurink RC
    RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters.
    BMC Genomics, 2014. 15: p. 402
    [PMID:24884371]
  4. Xu J, et al.
    SlMYC1 Regulates Type VI Glandular Trichome Formation and Terpene Biosynthesis in Tomato Glandular Cells.
    Plant Cell, 2018. 30(12): p. 2988-3005
    [PMID:30518626]