PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016441449.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 658aa    MW: 71968.9 Da    PI: 5.178
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016441449.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.22.3e-11486531454
                     HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
             HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                     +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ +I++L
  XP_016441449.1 486 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAFINEL 531
                     799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142151.6E-5473257IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.539482531IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.63E-14485536No hitNo description
SuperFamilySSF474592.36E-17485554IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.2E-18486552IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000106.4E-9486531IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.0E-15488537IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 658 aa     Download sequence    Send to blast
MTDYRIPTMT NIWSNTTSDD NMMEAFLSSD PSSFWAGTNT PTPRSSVSPA PAPVTGIAGD  60
PLKSMPYFNQ ESLQQRLQTL IDGAREAWTY AIFWQSSVVD FVSPSVLGWG DGYYKGEEDK  120
NKRKTAAFSP DFITEQEHRK KVLRELNSLI SGTQTGGEND AVDEEVTDTE WFFLISMTQS  180
FVNGSGLPGL AMYSSSPIWV TGRERLAASH CERARQAQGF GLQTMVCIPS ANGVVELGST  240
ELIFQSADLM NKVKILFDFN IDMGATTGSG SGSCAIQAEP DPSTLWLTDP PSSVVEVKDS  300
SNTVPSSNSS KQLVFGNENS ENVNQNSQQT QGFFTRELNF SEYGFDGSNT RSGNGNVNSS  360
RSCKPESGEI LNFGDSTKRN ASSANGSLFS GQSQFGPGPA EENKNKNKKR SPASRGSNEE  420
GMLSFVSGVI LPSSNTGKSG GGGDSDHSDL EASVVKEADS SRVVDPEKRP RKRGRKPANG  480
REEPLNHVEA ERQRREKLNQ RFYALRAVVP NVSKMDKASL LGDAIAFINE LKSKVQNSDS  540
DKDELRNQIE SLRNELANKG SNYTGPPPPN QDLKIVDMDI DVKVIGWDAM IRIQSNKKNH  600
PAARLMAALM ELDLDVHHAS VSVVNELMIQ QATVKMGSRL YTQEQLRISL TSRIAESR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A9e-67662602195Transcription factor MYC3
4rqw_B9e-67662602195Transcription factor MYC3
4rs9_A9e-67662602195Transcription factor MYC3
4yz6_A9e-67662602195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1467475KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in a number of promoters of jasmonate-induced genes (PubMed:15231736). Transcription activator involved in the transcriptional regulation of terpene biosynthesis in glandular trichomes (PubMed:24884371, PubMed:30518626). Binds to the promoter of the linalool synthase TPS5 and promotes TPS5 gene transactivation (PubMed:24884371). Acts synergistically with EOT1 in the transactivation of TPS5 (PubMed:24884371). Involved in type VI glandular trichome development (PubMed:30518626). Involved in the activation of terpene synthases required for volatile mono- and sesquiterpenes synthesis by the glandular cells of type VI trichomes (PubMed:30518626). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371, ECO:0000269|PubMed:30518626}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate and wounding. {ECO:0000269|PubMed:15231736}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankGQ8591610.0GQ859161.1 Nicotiana tabacum MYC2b transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001311866.10.0transcription factor MYC2-like
RefseqXP_009587276.10.0PREDICTED: transcription factor MYC2-like
SwissprotA0A060KY900.0MYC1_SOLLC; Transcription factor MYC1
TrEMBLD7P2360.0D7P236_TOBAC; MYC2b transcription factor
STRINGXP_009587276.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.16e-91bHLH family protein
Publications ? help Back to Top
  1. Todd AT,Liu E,Polvi SL,Pammett RT,Page JE
    A functional genomics screen identifies diverse transcription factors that regulate alkaloid biosynthesis in Nicotiana benthamiana.
    Plant J., 2010. 62(4): p. 589-600
    [PMID:20202168]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Spyropoulou EA,Haring MA,Schuurink RC
    RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters.
    BMC Genomics, 2014. 15: p. 402
    [PMID:24884371]
  4. Xu J, et al.
    SlMYC1 Regulates Type VI Glandular Trichome Formation and Terpene Biosynthesis in Tomato Glandular Cells.
    Plant Cell, 2018. 30(12): p. 2988-3005
    [PMID:30518626]