PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_009771457.1

Organism

Nicotiana sylvestris

Taxonomic ID

4096

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

E2F/DP

Protein Properties

Length: 310aa MW: 34827.5 Da PI: 8.5812

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_009771457.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	76.7	2.3e-24	20	85	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 rkeksL+ll+ +flkl+ ++ + + l+++a++L v +rRRiYDi+N+Le+++++++k+kn+++w+g XP_009771457.1 20 RKEKSLGLLCANFLKLCDREGVDSIGLDNAADQL---GV--ERRRIYDIVNILESVGVLSRKAKNQYKWNG 85 79***************999********.....****************************98 PP
2	E2F_TDP	68.5	8e-22	142	210	1	64
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliekkek 64 rkeksL +l+q+f+kl+++s+ + ++l+++a++L+ + +k+k RR+YDi+NV+ ++nliek ++ XP_009771457.1 142 RKEKSLMILAQNFVKLFHCSDVDLISLDKAASALLGDmhdpmAMKTKTRRLYDIANVFVSMNLIEKVKR 210 79****************************************************************655 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.3E-25	18	86	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	5.44E-16	19	83	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	3.8E-27	20	85	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.3E-20	21	85	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	3.7E-17	139	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	5.0E-18	142	215	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.8E-16	143	209	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.77E-10	144	210	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 310 aa Download sequence Send to blast
MSSSVNPEEA QWKNPNIYSR KEKSLGLLCA NFLKLCDREG VDSIGLDNAA DQLGVERRRI 60 YDIVNILESV GVLSRKAKNQ YKWNGFSAIP KAVDLLKKEG LKDQSVVSST SHNVANVIAC 120 NHSDLKEKGQ DKTSGSHKID NRKEKSLMIL AQNFVKLFHC SDVDLISLDK AASALLGDMH 180 DPMAMKTKTR RLYDIANVFV SMNLIEKVKR LKVAKDDELK DKNQEMSTER LNGHGTMDFV 240 FGPFGPASLS KAGVSGKENL KQTQNWEDLA STYRPQYQNK AASELFAHYV EAWESWQVEA 300 ANELHKQHLN

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4yo2_A	9e-34	19	208	3	222	Transcription factor E2F8
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15308755}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC215413	1e-67	AC215413.1 Solanum lycopersicum cultivar Heinz 1706 chromosome 2 clone C02HBa0189G15, complete sequence.
GenBank	HG975441	1e-67	HG975441.1 Solanum pennellii chromosome ch02, complete genome.
GenBank	HG975514	1e-67	HG975514.1 Solanum lycopersicum chromosome ch02, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009771457.1	0.0	PREDICTED: E2F transcription factor-like E2FF isoform X3
Swissprot	Q8RWL0	9e-82	E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBL	A0A1U7VUA7	0.0	A0A1U7VUA7_NICSY; E2F transcription factor-like E2FF isoform X3
STRING	PGSC0003DMT400003269	1e-169	(Solanum tuberosum)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G01330.1	4e-84	DP-E2F-like protein 3

Publications ? help Back to Top
Dohmann EM, et al. The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development, 2008. 135(11): p. 2013-22 [PMID:18434413]