PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf06822g04004.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 649aa    MW: 70677.4 Da    PI: 5.0881
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf06822g04004.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH35.22.3e-11477522454
                               HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                       HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                               +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ +I++L
  Niben101Scf06822g04004.1 477 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAFINEL 522
                               799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142154.4E-5566250IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.539473522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.52E-14476527No hitNo description
SuperFamilySSF474591.96E-17476545IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.105.3E-18477543IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000106.3E-9477522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.0E-15479528IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 649 aa     Download sequence    Send to blast
MTNIWSNTTS DDNMMEAFLS SDPSSFWAGT TTTPTPRSSV SPAPAPVTGI AVDPLTSMPY  60
FNQESLQQRL QTLIDGAREA WTYAIFWQSS VVDFTTHSVL GWGDGYYKGE EDKNKRKTAS  120
FSPDFITEQA HRKKVLRELN CLISGTQTGG ENDAVDEEVT DTEWFFLISM TQSFVNGSGL  180
PGLAMYSSSP IWVTGAERLA ASHCERARQA QGFGLQTIVC IPSGNGVVEL GSTELIFQTA  240
DLMNKVKVLF NFNIDMGATT GSGSGSCAIQ AEPDTSALWL TDPASSAVEV KDSSNTVPSS  300
NSSKQLVFGN ENSENGNQNS QQTQGFFTRE LNFSEYGFDG SNTRNGNVNS SRSCQPESGE  360
ILNFGDSTKR SASSANGSLF SGQSQFGPGP AEENKNKNKK RSPASRGSND EGMLSFVSGV  420
ILPSSNTGKS GGGGDSDQSD LEASVVKEAD SSRVVDPEKK PRKRGRKPAN GREEPLNHVE  480
AERQRREKLN QRFYALRAVV PNVSKMDKAS LLGDAIAFIN ELKSKVQNSD SDKEELRNQI  540
ESLRNELANK GSNYTGPPPL NQELKIVDMD IDVKVIGWDA MIRIQSNKKN HPAAKLMAAL  600
MELDLDVHHA SVSVVNELMI QQATVKMGSR LYTQEQLRIS LTSRIAESR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A2e-64592532195Transcription factor MYC3
4rqw_B2e-64592532195Transcription factor MYC3
4rs9_A2e-64592532195Transcription factor MYC3
4yz6_A2e-64592532195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1458466KKPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in a number of promoters of jasmonate-induced genes (PubMed:15231736). Transcription activator involved in the transcriptional regulation of terpene biosynthesis in glandular trichomes (PubMed:24884371, PubMed:30518626). Binds to the promoter of the linalool synthase TPS5 and promotes TPS5 gene transactivation (PubMed:24884371). Acts synergistically with EOT1 in the transactivation of TPS5 (PubMed:24884371). Involved in type VI glandular trichome development (PubMed:30518626). Involved in the activation of terpene synthases required for volatile mono- and sesquiterpenes synthesis by the glandular cells of type VI trichomes (PubMed:30518626). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24884371, ECO:0000269|PubMed:30518626}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate and wounding. {ECO:0000269|PubMed:15231736}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009800420.10.0PREDICTED: transcription factor MYC2-like
SwissprotA0A060KY900.0MYC1_SOLLC; Transcription factor MYC1
TrEMBLD7P2290.0D7P229_NICBE; BHLH2 transcription factor
STRINGXP_009800420.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.10.0bHLH family protein
Publications ? help Back to Top
  1. Todd AT,Liu E,Polvi SL,Pammett RT,Page JE
    A functional genomics screen identifies diverse transcription factors that regulate alkaloid biosynthesis in Nicotiana benthamiana.
    Plant J., 2010. 62(4): p. 589-600
    [PMID:20202168]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Spyropoulou EA,Haring MA,Schuurink RC
    RNA sequencing on Solanum lycopersicum trichomes identifies transcription factors that activate terpene synthase promoters.
    BMC Genomics, 2014. 15: p. 402
    [PMID:24884371]
  4. Xu J, et al.
    SlMYC1 Regulates Type VI Glandular Trichome Formation and Terpene Biosynthesis in Tomato Glandular Cells.
    Plant Cell, 2018. 30(12): p. 2988-3005
    [PMID:30518626]