PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr8g067280.1
Common NameMTR_8g067280
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family bHLH
Protein Properties Length: 649aa    MW: 71039.4 Da    PI: 5.4703
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr8g067280.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.31.1e-12462507454
                      HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
              HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                      +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Medtr8g067280.1 462 NHVEAERQRREKLNQKFYALRAVVPNV-----SKMDKASLLGDAISYINEL 507
                      799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142153.6E-5154234IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.25458507IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474591.57E-18461527IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.88E-15461512No hitNo description
Gene3DG3DSA:4.10.280.101.4E-18462526IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.5E-10462507IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.7E-16464513IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 649 aa     Download sequence    Send to blast
MNNIWDDNSS VMEAFMTTSD ISSFWLPTPH SATSTTAAPV PPPPQQSLFN QETLQHRLQA  60
LIEGAKESWT YAIFWQSSYD YTMATPLLGW GDGYYKGEDD KVKLKRVTPP EEQAHRRKIL  120
RELNTLISGG SSVSDDAVEE DVTDTEWFFL TSMTQSFVNG TGSLSQAYFN STPVWITGAE  180
RLSGSPCERA REARVHGFQT LVCIPTSSSG VVELASTEMI PYNADLMEKI RVLFNFNNPE  240
TGSWPLNSIT TSENDPSSVW LNDLSASAAI EIRESTVNTA AVPAMNATIP ANATVGKTLP  300
FETNGSTSTL TETTAVNFAQ RQNQNNQNHS FFLKELNFSG SMKPESGEIL SFGESKKSSY  360
ITGNGTFFSG QSQFVAGEEN RKRKSPISRS SIDDGMLSFT SGVVLPSSNM KSSSRGGGGD  420
SDHSDLDVSA VKEGESSRVV EPGKRPKKRG RKPANGREEP LNHVEAERQR REKLNQKFYA  480
LRAVVPNVSK MDKASLLGDA ISYINELKSK LQGLESSKGE LEKQLGATKK ELELVASKNQ  540
SQNPIPLDKE KEKTTSSTSS SKLIDLDIDV KIMGWDAMIR IQCSKKNHPA AKLMAALKEL  600
DLDVNHASVS VVNDLMIQQA SVNMGSRFYT QEQLLSLLSS KIGDAQGD*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A5e-68462371195Transcription factor MYC3
4rqw_B5e-68462371195Transcription factor MYC3
4rs9_A5e-68462371195Transcription factor MYC3
4yz6_A5e-68462371195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1443451KRPKKRGRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mtr.146950.0leaf| pod| root| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed at low levels in roots, stems, leaves, flowers and fruits. {ECO:0000269|PubMed:15231736}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr8g067280.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankDQ3995282e-83DQ399528.1 Pisum sativum G-box element binding protein (GBF) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003628820.20.0transcription factor MYC2
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLG7LHR20.0G7LHR2_MEDTR; Basic helix loop helix (BHLH) family transcription factor
STRINGAET032960.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF29383364
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-156bHLH family protein
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  4. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  5. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  6. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  7. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  8. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]