PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.18G042000.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family MYB
Protein Properties Length: 316aa    MW: 33896 Da    PI: 8.4745
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.18G042000.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding59.38.4e-191358147
                         TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
      Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47
                         +g+W++eEde l ++v+ +G+++W++I++ ++ gR++k+c++rw + 
  Manes.18G042000.1.p 13 KGPWSPEEDEALQRLVQNYGPRNWSLISKSIP-GRSGKSCRLRWCNQ 58
                         79******************************.***********985 PP
2Myb_DNA-binding57.82.5e-1867109347
                          SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
      Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 
                          ++++eEde +v+a++++G++ W+tIar ++ gRt++ +k++w++ 
  Manes.18G042000.1.p  67 PFSPEEDETIVKAHARFGNK-WATIARLLN-GRTDNAIKNHWNST 109
                          89******************.*********.***********986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129426.047863IPR017930Myb domain
SuperFamilySSF466894.49E-3210106IPR009057Homeodomain-like
SMARTSM007171.1E-161261IPR001005SANT/Myb domain
PfamPF002491.9E-181358IPR001005SANT/Myb domain
Gene3DG3DSA:1.10.10.606.6E-261466IPR009057Homeodomain-like
CDDcd001675.06E-161557No hitNo description
SMARTSM007174.3E-1564112IPR001005SANT/Myb domain
PROSITE profilePS5129421.44965114IPR017930Myb domain
CDDcd001672.96E-1267110No hitNo description
PfamPF002492.0E-1567109IPR001005SANT/Myb domain
Gene3DG3DSA:1.10.10.601.9E-2367113IPR009057Homeodomain-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 316 aa     Download sequence    Send to blast
MASTARKDVD RIKGPWSPEE DEALQRLVQN YGPRNWSLIS KSIPGRSGKS CRLRWCNQLS  60
PEVEHRPFSP EEDETIVKAH ARFGNKWATI ARLLNGRTDN AIKNHWNSTL KRKCSSLSDD  120
LSDDGNAQQP LKRSASVGAG TNISGLQLNP NSPSGSDVSD SSLPGMPSSP VYRPIAKAGS  180
LVSPGLLIDA VSSTTDPPTS LSLSLPGSDS CEASNPISIS GSGSGFNQAV NPIQDVHTPV  240
AQPAAGAVQQ APAGQYKGIG YEKQFFSPEF LAVMQEMIRK EVRNYMSGIE QNGLCLQTEA  300
IRNAVVKRIG ISRIE*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1gv2_A2e-41121143105MYB PROTO-ONCOGENE PROTEIN
1mse_C2e-41121143105C-Myb DNA-Binding Domain
1msf_C2e-41121143105C-Myb DNA-Binding Domain
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor (PubMed:23067202, PubMed:23603962). Represses the expression of protein phosphatases 2C in response to abscisic acid (ABA). Confers resistance to abiotic stresses dependent of ABA (PubMed:18162593, PubMed:9678577). In response to auxin, activates the transcription of the auxin-responsive gene IAA19. The IAA19 transcription activation by MYB44 is enhanced by direct interaction between MYB44 and PYL8 (PubMed:24894996). Transcriptional activator of WRKY70 by direct binding to its promoter region, especially at 5'-TAACNG-3' and 5'-CNGTTA-3' symmetric motifs (PubMed:23067202, PubMed:23603962). Activates salicylic acid (SA)- mediated defenses and subsequent resistance to biotrophic pathogen P.syringae pv. tomato DC3000, but represses jasmonic acid (JA)-mediated defenses responses against the necrotrophic pathogen A.brassicicola (PubMed:23067202). {ECO:0000269|PubMed:18162593, ECO:0000269|PubMed:23067202, ECO:0000269|PubMed:23603962, ECO:0000269|PubMed:24894996, ECO:0000269|PubMed:9678577}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.18G042000.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By drought, cold, high salinity, cadmium (CdCl(2)), salicylic acid (SA), jasmonate (JA), ethylene, gibberellic acid (GA), and ABA (PubMed:16463103, PubMed:18162593, PubMed:23067202). The induction by JA is COI1-dependent (PubMed:23067202). {ECO:0000269|PubMed:16463103, ECO:0000269|PubMed:18162593, ECO:0000269|PubMed:23067202}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021601648.10.0transcription factor MYB44-like
SwissprotQ9FDW13e-98MYB44_ARATH; Transcription factor MYB44
TrEMBLA0A2C9U0500.0A0A2C9U050_MANES; Uncharacterized protein
STRINGcassava4.1_034350m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF84334124
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G67300.13e-79myb domain protein r1
Publications ? help Back to Top
  1. Li C,Chang PP,Ghebremariam KM,Qin L,Liang Y
    Overexpression of tomato SpMPK3 gene in Arabidopsis enhances the osmotic tolerance.
    Biochem. Biophys. Res. Commun., 2014. 443(2): p. 357-62
    [PMID:24275141]
  2. Jaradat MR,Feurtado JA,Huang D,Lu Y,Cutler AJ
    Multiple roles of the transcription factor AtMYBR1/AtMYB44 in ABA signaling, stress responses, and leaf senescence.
    BMC Plant Biol., 2013. 13: p. 192
    [PMID:24286353]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Li D, et al.
    Arabidopsis ABA receptor RCAR1/PYL9 interacts with an R2R3-type MYB transcription factor, AtMYB44.
    Int J Mol Sci, 2014. 15(5): p. 8473-90
    [PMID:24828206]
  5. Xu DB, et al.
    A G-protein β subunit, AGB1, negatively regulates the ABA response and drought tolerance by down-regulating AtMPK6-related pathway in Arabidopsis.
    PLoS ONE, 2015. 10(1): p. e0116385
    [PMID:25635681]
  6. Hieno A, et al.
    Possible Involvement of MYB44-Mediated Stomatal Regulation in Systemic Resistance Induced by Penicillium simplicissimum GP17-2 in Arabidopsis.
    Microbes Environ., 2016. 31(2): p. 154-9
    [PMID:27301421]
  7. Zhao Q, et al.
    AtMYB44 Positively Regulates the Enhanced Elongation of Primary Roots Induced by N-3-Oxo-Hexanoyl-Homoserine Lactone in Arabidopsis thaliana.
    Mol. Plant Microbe Interact., 2016. 29(10): p. 774-785
    [PMID:27604593]
  8. Song L, et al.
    A transcription factor hierarchy defines an environmental stress response network.
    Science, 2017.
    [PMID:27811239]
  9. Nguyen NH,Cheong JJ
    H2A.Z-containing nucleosomes are evicted to activate AtMYB44 transcription in response to salt stress.
    Biochem. Biophys. Res. Commun., 2018. 499(4): p. 1039-1043
    [PMID:29649476]
  10. Nguyen NH,Cheong JJ
    AtMYB44 interacts with TOPLESS-RELATED corepressors to suppress protein phosphatase 2C gene transcription.
    Biochem. Biophys. Res. Commun., 2018. 507(1-4): p. 437-442
    [PMID:30448055]