PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.05G052300.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family MYB
Protein Properties Length: 305aa    MW: 34109.4 Da    PI: 6.3752
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.05G052300.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding41.62.8e-131055146
                         TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
      Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46
                         +g+W +eEde l++ v+++G ++W++I ++  + Rt+k+c++rw +
  Manes.05G052300.1.p 10 KGPWKAEEDEVLINHVQRYGARDWSSIRSKGLLQRTGKSCRLRWVN 55
                         79*************************8887799**********87 PP
2Myb_DNA-binding41.63e-1366105344
                          SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
      Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                          +++ eE+   +++ +q+G++ W++Ia +++ gRt++++k++w
  Manes.05G052300.1.p  66 KFSMEEERVVIELQAQFGNK-WAKIATYLP-GRTDNDVKNFW 105
                          7999****************.*********.*********** PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.601.0E-20458IPR009057Homeodomain-like
PROSITE profilePS5129420.22561IPR017930Myb domain
SuperFamilySSF466893.91E-288105IPR009057Homeodomain-like
SMARTSM007176.0E-10959IPR001005SANT/Myb domain
CDDcd001676.61E-111257No hitNo description
PfamPF139216.7E-121363No hitNo description
Gene3DG3DSA:1.10.10.607.8E-1859111IPR009057Homeodomain-like
PROSITE profilePS5129417.84662113IPR017930Myb domain
SMARTSM007175.3E-1163111IPR001005SANT/Myb domain
CDDcd001676.96E-1066105No hitNo description
PfamPF002491.3E-1166105IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0048235Biological Processpollen sperm cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 305 aa     Download sequence    Send to blast
MEAKRDEIRK GPWKAEEDEV LINHVQRYGA RDWSSIRSKG LLQRTGKSCR LRWVNKLRPN  60
LKNGCKFSME EERVVIELQA QFGNKWAKIA TYLPGRTDND VKNFWSSRQK RLARILQTSA  120
TPSSSSSSNF KPRKAKKEVS VFHEVPTHQA PVFSFSMEEE SSTKAQSCSS SFIETTEPVS  180
TVPLPFHADL VKTELPSYEA NLAQMEAQTQ IPFPEISQNQ PDLTFSPESQ ELLARLDDPF  240
LFNMFGAVDA PELGAQPSLG PPLFGPVSSC INGGREARSP TTHGTFFDDF PSDVFDNIEP  300
LPSP*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C5e-28711124126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.05G052300.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021614050.10.0transcription factor DUO1-like
SwissprotA0A178VEK75e-95DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A2C9VTJ00.0A0A2C9VTJ0_MANES; Uncharacterized protein
STRINGcassava4.1_022856m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36933164
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.11e-96MYB family protein
Publications ? help Back to Top
  1. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  2. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  3. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]