PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000215235
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 187aa    MW: 22297.4 Da    PI: 9.0748
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000215235genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H220.71.1e-061438123
                   EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2  1 ykCp..dCgksFsrksnLkrHirtH 23
                   y+Cp   Cgk Fs   +L+ H++tH
  MDP0000215235 14 YVCPreGCGKAFSLEIYLRYHMKTH 38
                   99**********************9 PP
2zf-C2H211.30.00114466121
                   EEET..TTTEEESSHHHHHHHHH CS
        zf-C2H2  1 ykCp..dCgksFsrksnLkrHir 21
                   ykCp   C ++F   + Lk+Hi 
  MDP0000215235 44 YKCPypACLRRFAYEYKLKNHIV 66
                   99*******************96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576679.18E-12248No hitNo description
Gene3DG3DSA:3.30.160.602.6E-13236IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003555.3E-41438IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.2171443IPR007087Zinc finger, C2H2
PROSITE patternPS0002801638IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.607.1E-83765IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.144469IPR015880Zinc finger, C2H2-like
PROSITE profilePS501578.9744478IPR007087Zinc finger, C2H2
PROSITE patternPS0002804669IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.609.7E-9116145IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576676.63E-6120147No hitNo description
SMARTSM003550.015122147IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.723122152IPR007087Zinc finger, C2H2
PROSITE patternPS000280124147IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 187 aa     Download sequence    Send to blast
MTRHFHIHTV EKNYVCPREG CGKAFSLEIY LRYHMKTHSA DNYYKCPYPA CLRRFAYEYK  60
LKNHIVDYHE TIHQSKDKIR ESRKKVQIDE PVCVPKYAIL LAEKQIRTPE PPYDKESSDR  120
PYACIYDGCS KTYIHEDKLK LHYRKMHPGH VFDVARNEID EASDQDAYAG KRVNVKSQQN  180
MLRPNWK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C4e-1416850117PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Rapidly induced following seed germination, especially in tender cotyledons. {ECO:0000269|PubMed:26961720}.
UniprotTISSUE SPECIFICITY: Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves. {ECO:0000269|PubMed:26961720}.
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028950948.11e-122zinc finger transcription factor YY1-like isoform X1
RefseqXP_028950949.11e-122zinc finger transcription factor YY1-like isoform X2
SwissprotQ2V3L31e-47YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A498HU861e-121A0A498HU86_MALDO; Uncharacterized protein
STRINGXP_008339531.11e-121(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.22e-50C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]