PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G06634.2

Common Name

AtYY1, F8H12, YY1

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

C2H2

Protein Properties

Length: 349aa MW: 40084.3 Da PI: 5.9299

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G06634.2	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	10.9	0.0014	43	65	3	23
ET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 3 Cp..dCgksFsrksnLkrHirtH 23 C+ Cgk+F + s L++H H AT4G06634.2 43 CSydGCGKTFFDVSALRKHSHIH 65 78889**************7766 PP
2	zf-C2H2	17.2	1.5e-05	70	94	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 y+C Cgk F ++s LkrH H AT4G06634.2 70 YVCDqeGCGKKFLDSSKLKRHYLIH 94 99*******************9988 PP
3	zf-C2H2	20.2	1.5e-06	100	124	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 y C+ Cgk Fs nL++H++tH AT4G06634.2 100 YICTyeGCGKAFSLDFNLRSHMKTH 124 899999******************9 PP
4	zf-C2H2	13.1	0.00029	192	217	1	23
EEET..TTTEEESSHHHHHHHHHH.T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt.H 23 y Cp C k + + + Lk H+++ H AT4G06634.2 192 YACPyeGCEKAYIHEYKLKLHLKReH 217 89*********************999 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	3.2E-14	36	67	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	10.949	41	70	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.0053	41	65	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	43	65	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	2.46E-9	44	94	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.3E-14	68	92	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	14.274	70	99	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.0011	70	94	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	72	94	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	3.93E-15	81	136	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.1E-21	93	126	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	5.2E-4	100	124	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.84	100	129	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	102	124	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	8.6E-6	127	151	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.12	130	155	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	132	155	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.14E-5	187	215	No hit	No description
Gene3D	G3DSA:3.30.160.60	5.9E-9	188	214	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	9.328	192	222	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.012	192	217	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	194	217	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0043565	Molecular Function	sequence-specific DNA binding
GO:0046872	Molecular Function	metal ion binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000293	anatomy	guard cell

Sequence ? help Back to Top
Protein Sequence Length: 349 aa Download sequence Send to blast
MLNCIIVLLL LPEDTFSRLK EKEKEPDVPE PEPEPTTEIL FLCSYDGCGK TFFDVSALRK 60 HSHIHGERQY VCDQEGCGKK FLDSSKLKRH YLIHTGERNY ICTYEGCGKA FSLDFNLRSH 120 MKTHSQENYH ICPYSGCVKR YAHEYKLKNH VAAYHEKNGG GETPKYTPPA EKVLRTVKTP 180 ATVCGPSSDR PYACPYEGCE KAYIHEYKLK LHLKREHPGH LQEENADTPT LNKHNGNDRN 240 EIDDGSDQDV YRKHASNGKG QTHKQQSRAK PNMRTPPAKV GKKGSTSSPA KARIAKKPWQ 300 AKETFEEVER EEEEDSEETE EDRDNVEDGW RFGENNEDDD DDEETEYED

Sequence ? help Back to Top

Protein Sequence Length: 349 aa Download sequence Send to blast

MLNCIIVLLL LPEDTFSRLK EKEKEPDVPE PEPEPTTEIL FLCSYDGCGK TFFDVSALRK  60
HSHIHGERQY VCDQEGCGKK FLDSSKLKRH YLIHTGERNY ICTYEGCGKA FSLDFNLRSH  120
MKTHSQENYH ICPYSGCVKR YAHEYKLKNH VAAYHEKNGG GETPKYTPPA EKVLRTVKTP  180
ATVCGPSSDR PYACPYEGCE KAYIHEYKLK LHLKREHPGH LQEENADTPT LNKHNGNDRN  240
EIDDGSDQDV YRKHASNGKG QTHKQQSRAK PNMRTPPAKV GKKGSTSSPA KARIAKKPWQ  300
AKETFEEVER EEEEDSEETE EDRDNVEDGW RFGENNEDDD DDEETEYED

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	4e-37	43	154	8	117	PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.47264	0.0	inflorescence\| silique

Expression -- Microarray ? help Back to Top
Source	ID
Expression Atlas	AT4G06634
AtGenExpress	AT4G06634

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Rapidly induced following seed germination, especially in tender cotyledons. {ECO:0000269\|PubMed:26961720}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves. {ECO:0000269\|PubMed:26961720}.

Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Function -- GeneRIF ? help Back to Top
genome-wide target gene analysis revealed that AtYY1 was involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism, and stress response[AtYY1] [PMID: 22508367]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G06634.2

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G06634

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AB073162	0.0	AB073162.1 Arabidopsis thaliana DNA, chromosome 4 centromere region, BAC clone:F8H12.
GenBank	CP002687	0.0	CP002687.1 Arabidopsis thaliana chromosome 4 sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001031589.1	0.0	zinc finger (C2H2 type) family protein
Swissprot	Q2V3L3	0.0	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	A0A178V3M9	0.0	A0A178V3M9_ARATH; Uncharacterized protein
STRING	AT4G06634.1	0.0	(Arabidopsis thaliana)

Link Out ? help Back to Top
Phytozome	AT4G06634.2
Entrez Gene	826093
iHOP	AT4G06634
wikigenes	AT4G06634

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Reiland S, et al. Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks. Plant Physiol., 2009. 150(2): p. 889-903 [PMID:19376835] Rehrauer H, et al. AGRONOMICS1: a new resource for Arabidopsis transcriptome profiling. Plant Physiol., 2010. 152(2): p. 487-99 [PMID:20032078] Wu X,Cheng Y,Li T,Wang Z,Liu JY In vitro identification of DNA-binding motif for the new zinc finger protein AtYY1. Acta Biochim. Biophys. Sin. (Shanghai), 2012. 44(6): p. 483-9 [PMID:22508367] Lai Z, et al. MED18 interaction with distinct transcription factors regulates multiple plant functions. Nat Commun, 2014. 5: p. 3064 [PMID:24451981] Bieluszewski T, et al. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex. BMC Plant Biol., 2015. 15: p. 75 [PMID:25849764] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]