PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000212411
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family BES1
Protein Properties Length: 280aa    MW: 31347.9 Da    PI: 10.2273
Description BES1 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000212411genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1DUF822708.3e-22241140
         DUF822  1 ggsgrkptwkErEnnkrRERrRRaiaakiyaGLRaqGnyk 40
                   ++++r+ptwkErEnnk+RERr Raiaakiy+GLR++Gnyk
  MDP0000212411  2 TSGTRMPTWKERENNKKRERRYRAIAAKIYSGLRMYGNYK 41
                   5899***********************************8 PP
2HLH22.22.6e-07255280429
                    HHHHHHHHHHHHHHHHHHHHHCTSCC CS
            HLH   4 ahnerErrRRdriNsafeeLrellPk 29 
                    +h e+Er+RR+++N++f  Lr ++P+
  MDP0000212411 255 NHVEAERQRREKLNQRFYALRAVVPN 280
                    799*********************95 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF056871.4E-17341IPR008540BES1/BZR1 plant transcription factor, N-terminal
PfamPF142151.0E-1058107IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088811.458251280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.62E-7252280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000834.50E-6254280No hitNo description
Gene3DG3DSA:4.10.280.106.1E-7254280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.3E-4255280IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 280 aa     Download sequence    Send to blast
MTSGTRMPTW KERENNKKRE RRYRAIAAKI YSGLRMYGNY KWLICVRGRI RVQNGFGSSQ  60
CERARQGQVF GLQTMVCVPT ANEVVELGST ELIYQSSDLM NKTQSFFTGE LNFSDYNVYD  120
GSSVKNSNSN SNSHSLKPES GEILNFGESK RSSYSANGKL FLGHSQMTAA EDNNSKKKRS  180
PPSRGSNDEG ILSFSSGVIL PSSCVVKSSG GADSDHSDLE ASVVREADSS RVVDQEKRPR  240
KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYALRAVVPN
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A4e-1459107144192Transcription factor MYC3
4rqw_B4e-1459107144192Transcription factor MYC3
4rs9_A4e-1459107144192Transcription factor MYC3
4yz6_A4e-1459107144192Transcription factor MYC3
5gnj_A6e-15249280233Transcription factor MYC2
5gnj_B6e-15249280233Transcription factor MYC2
5gnj_E6e-15249280233Transcription factor MYC2
5gnj_F6e-15249280233Transcription factor MYC2
5gnj_G6e-15249280233Transcription factor MYC2
5gnj_I6e-15249280233Transcription factor MYC2
5gnj_M6e-15249280233Transcription factor MYC2
5gnj_N6e-15249280233Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1236244KRPRKRGRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.122470.0bud| fruit| leaf| root| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed at low levels in roots, stems, leaves, flowers and fruits. {ECO:0000269|PubMed:15231736}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008341963.21e-107transcription factor MYC2-like
SwissprotA0A3Q7HRZ61e-68MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A498HHL41e-106A0A498HHL4_MALDO; Uncharacterized protein
STRINGXP_008353557.10.0(Malus domestica)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.13e-36bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]