PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000210323
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 410aa    MW: 47605.3 Da    PI: 7.6048
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000210323genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.20.0005679101323
                    ET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                    C+   Cgk+F +   L++H  +H
  MDP0000210323  79 CSydGCGKTFIDAGALRKHSHVH 101
                    78889**************8776 PP
2zf-C2H222.23.7e-07173197123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    y+Cp   Cgk Fs   nL++H++tH
  MDP0000210323 173 YVCPheGCGKAFSLDFNLRSHMKTH 197
                    99**********************9 PP
3zf-C2H216.22.9e-05203227123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    + Cp  dCgk++ + + Lk+Hi  H
  MDP0000210323 203 HICPypDCGKRYAHEYKLKNHIVAH 227
                    679999****************885 PP
4zf-C2H214.40.00011267292123
                    EEET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                    y Cp   C+k + + + Lk H+r+ H
  MDP0000210323 267 YACPydGCSKAYIHEYKLKLHLRReH 292
                    89*********************999 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.609.3E-1472102IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.9777106IPR007087Zinc finger, C2H2
SMARTSM003550.002577101IPR015880Zinc finger, C2H2-like
SuperFamilySSF576673.41E-678102No hitNo description
PROSITE patternPS00028079101IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.606.1E-4103116IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
Gene3DG3DSA:3.30.160.605.2E-6152172IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576676.16E-15154207No hitNo description
SMARTSM003551.7E-4173197IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.882173202IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.605.8E-15173197IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280175197IPR007087Zinc finger, C2H2
SuperFamilySSF576679.12E-5197231No hitNo description
Gene3DG3DSA:3.30.160.601.5E-8199227IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.408203232IPR007087Zinc finger, C2H2
SMARTSM003550.0097203227IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280205228IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.607.5E-9261290IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576674.47E-5264290No hitNo description
SMARTSM003550.0065267292IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.951267297IPR007087Zinc finger, C2H2
PROSITE patternPS000280269292IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 410 aa     Download sequence    Send to blast
MDSQFHHNYF ERRPIFRSKT PAVKWFKEWV PQDVVATGGK CSLMKWVTAD TLKALNEKSK  60
KTVAPEPEPE PTTEVLFLCS YDGCGKTFID AGALRKHSHV HGEKQYVCHY EGCGKCLFYM  120
DXVKLWVTVM SNKWRRVVSF LIWYPKAKYK KKKFLDSSKL KRHFLIHTGE RDYVCPHEGC  180
GKAFSLDFNL RSHMKTHSQE NYHICPYPDC GKRYAHEYKL KNHIVAHHEK MPIDEPVSVP  240
KYATPPAEKQ IRTPKPPYSN ASLDRPYACP YDGCSKAYIH EYKLKLHLRR EHPGHVSDEN  300
AENPANNAHN EMDEASDQDA YAGKRMNGKS QKQNRPKPNL KYPPAKIAQR KGSTPSPAPM  360
NTMKKPWPIK EDVYDEEDSE ETEEDRDNVE DGWRYGENND DDDEETEDED
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C4e-27702272117PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.81660.0bud| fruit| leaf| root
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Rapidly induced following seed germination, especially in tender cotyledons. {ECO:0000269|PubMed:26961720}.
UniprotTISSUE SPECIFICITY: Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves. {ECO:0000269|PubMed:26961720}.
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008365310.20.0zinc finger transcription factor YY1
SwissprotQ2V3L31e-152YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A498J9V10.0A0A498J9V1_MALDO; Uncharacterized protein
STRINGXP_008365310.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-136C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]