PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000209277
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 249aa    MW: 29252.4 Da    PI: 8.2128
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000209277genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.20.00111941323
                   ET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2  3 Cp..dCgksFsrksnLkrHirtH 23
                   C+   Cgk F +   L++H   H
  MDP0000209277 19 CShdSCGKIFIDAGALRKHADIH 41
                   77779**************8877 PP
2zf-C2H220.21.6e-0676100123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    y+Cp   Cgk Fs   +L+ H++tH
  MDP0000209277  76 YVCPreGCGKAFSLEIYLRYHMKTH 100
                    99**********************9 PP
3zf-C2H210.80.0016106128121
                    EEET..TTTEEESSHHHHHHHHH CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHir 21 
                    ykCp   C ++F   + Lk+Hi 
  MDP0000209277 106 YKCPypACLRRFAYEYKLKNHIV 128
                    99*******************96 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.603.1E-101242IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576678.72E-61366No hitNo description
PROSITE profilePS5015710.971746IPR007087Zinc finger, C2H2
SMARTSM003550.121741IPR015880Zinc finger, C2H2-like
PROSITE patternPS0002801941IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.2E-104365IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015711.1364675IPR007087Zinc finger, C2H2
SMARTSM003550.374670IPR015880Zinc finger, C2H2-like
PROSITE patternPS0002804870IPR007087Zinc finger, C2H2
SuperFamilySSF576674.44E-1357110No hitNo description
Gene3DG3DSA:3.30.160.602.0E-146698IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015712.21776105IPR007087Zinc finger, C2H2
SMARTSM003555.3E-476100IPR015880Zinc finger, C2H2-like
PROSITE patternPS00028078100IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.609.7E-899127IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS501578.974106140IPR007087Zinc finger, C2H2
SMARTSM003550.14106131IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280108131IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.601.5E-8178207IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576679.9E-6182209No hitNo description
PROSITE profilePS501579.723184214IPR007087Zinc finger, C2H2
SMARTSM003550.015184209IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280186209IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 249 aa     Download sequence    Send to blast
MALEPELEPE PTTEVLFLCS HDSCGKIFID AGALRKHADI HAERQHVCWF EGCGKKFLDS  60
SKMTRHFHIH TVEKNYVCPR EGCGKAFSLE IYLRYHMKTH SADNYYKCPY PACLRRFAYE  120
YKLKNHIVDY HETIHQSKDK IRESRKKVQI DEPVCVPKYA ILLAEKQIRT PEPPYDKESS  180
DRPYACIYDG CSKTYIHEDK LKLHYRKMHP GHVFDVARNE IDEASDQDAY AGKRVNVKSQ  240
QNMLRPNWK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C1e-28101302118PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Rapidly induced following seed germination, especially in tender cotyledons. {ECO:0000269|PubMed:26961720}.
UniprotTISSUE SPECIFICITY: Mostly expressed in flowers, to a lower extent in seedlings, stems and leaves, and, at low levels, in roots and senescent leaves. {ECO:0000269|PubMed:26961720}.
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028950948.11e-172zinc finger transcription factor YY1-like isoform X1
RefseqXP_028950949.11e-172zinc finger transcription factor YY1-like isoform X2
SwissprotQ2V3L31e-77YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A498HU861e-171A0A498HU86_MALDO; Uncharacterized protein
STRINGXP_009345834.11e-136(Pyrus x bretschneideri)
STRINGXP_009345844.11e-136(Pyrus x bretschneideri)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF56493354
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.22e-78C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]