PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000181649
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 391aa    MW: 45091.7 Da    PI: 8.5305
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000181649genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H219.42.9e-066483221
                   EETTTTEEESSHHHHHHHHH CS
        zf-C2H2  2 kCpdCgksFsrksnLkrHir 21
                   +C+ Cg++F+ + +Lk+H++
  MDP0000181649 64 TCEECGTTFKKPAHLKQHLQ 83
                   6*****************86 PP
2zf-C2H216.13.2e-05143167123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    y C+  dC+ s++rk++L+rH+  H
  MDP0000181649 143 YICSvdDCHSSYRRKDHLTRHLLQH 167
                    89*******************9887 PP
3zf-C2H213.40.00023172197123
                    EEET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                    +kCp  +C++ F  + n krH +  H
  MDP0000181649 172 FKCPveNCNREFVFQGNIKRHVNElH 197
                    89*******************99888 PP
4zf-C2H215.26.2e-05212236123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    ++C+   Cgk F+  s L++H  +H
  MDP0000181649 212 HVCQeiGCGKEFRYASRLRKHEESH 236
                    79*******************9988 PP
5zf-C2H217.31.3e-05303327223
                    EET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   2 kCp..dCgksFsrksnLkrHirt.H 23 
                    kC    C ++F++ksnL +H +  H
  MDP0000181649 303 KCDykGCLRTFTTKSNLXKHVKAvH 327
                    688889**************99877 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576672.35E-51782No hitNo description
SMARTSM00355471941IPR015880Zinc finger, C2H2-like
SMARTSM00355236383IPR015880Zinc finger, C2H2-like
SuperFamilySSF576673.6E-6139169No hitNo description
Gene3DG3DSA:3.30.160.606.0E-9139169IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS501579.702143172IPR007087Zinc finger, C2H2
SMARTSM003550.014143167IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280145167IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.6E-4170197IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.08E-5170197No hitNo description
SMARTSM003550.064172197IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.762172202IPR007087Zinc finger, C2H2
PROSITE patternPS000280174197IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.9E-6207236IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.658212241IPR007087Zinc finger, C2H2
SMARTSM003550.011212236IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280214236IPR007087Zinc finger, C2H2
SMARTSM0035514244269IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280246269IPR007087Zinc finger, C2H2
SMARTSM0035516272293IPR015880Zinc finger, C2H2-like
SuperFamilySSF576671.56E-6284339No hitNo description
PROSITE profilePS5015712.466302332IPR007087Zinc finger, C2H2
SMARTSM003550.0014302327IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.601.0E-6303327IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280304327IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.606.1E-5328356IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003555.8333359IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280335359IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 391 aa     Download sequence    Send to blast
MDKGAGEKEG PIVRDIRRHY CDYCGICRSK KSLIASHILS HHKEEMEMAD GDGGGDXXEX  60
NSNTCEECGT TFKKPAHLKQ HLQNISFAGI NIYXKXTMDS VKHWIPHKEL QNAIRFXLDG  120
LVPGGRPPVK LHQANLSHAL RPYICSVDDC HSSYRRKDHL TRHLLQHQGK LFKCPVENCN  180
REFVFQGNIK RHVNELHIED CPSADGGXQK QHVCQEIGCG KEFRYASRLR KHEESHVKLD  240
TVEAFCFEPG CMKHFTNDQC LKVHIQSCHQ HTTCEICGAK QLRQNMKRHL LTHEXRXSIE  300
RIKCDYKGCL RTFTTKSNLX KHVKAVHLEH KPFVCSFSGC GMRFAYKHVR DNHEKTGCHV  360
YTHGDFEEAD EQFRSRPRGG RKRQCPDIPM X
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Both isoforms 1 and 2 transcripts are expressed in seedlings and both TFIIIA and TFIIIA-C are present at similar ratios in 10-day-old seedlings (at protein level). In correlation with the reorganization of 5S rDNA chromatin to a mature state, full-length isoform 1 protein TFIIIA with transcriptional activity accumulates and permits de novo transcription of 5S rRNA. Isoforms 1 and 2 transcripts accumulate in various tissues of the reproductive phase, including flowers and siliques, but only isoform 2 is present in mature seeds. In flowers, both TFIIIA and TFIIIA-C are present at similar ratios (at protein level). Very low amounts of TFIIIA are found in extracts from fresh siliques compared to TFIIIA-C. The amount of full-length TFIIIA protein progressively increases from fresh siliques to seeds concomitant with lower proportions of the shorter TFIIIA-C protein (at protein level) thus leading to 5S rRNA accumulation in the seed. {ECO:0000269|PubMed:22353599}.
UniprotTISSUE SPECIFICITY: Expressed in seedlings, flowers, siliques and seeds. {ECO:0000269|PubMed:22353599}.
Functional Description ? help Back to Top
Source Description
UniProtEssential protein (PubMed:22353599). Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599). Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599). {ECO:0000269|PubMed:12711688, ECO:0000269|PubMed:22353599}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028949414.10.0transcription factor IIIA-like isoform X1
SwissprotQ84MZ41e-112TF3A_ARATH; Transcription factor IIIA
TrEMBLA0A498HTS70.0A0A498HTS7_MALDO; Uncharacterized protein
STRINGXP_008339227.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF30693370
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G72050.21e-114transcription factor IIIA