PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000175922
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 433aa    MW: 49889.5 Da    PI: 8.3142
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000175922genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H219.82.1e-066485223
                   EETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2  2 kCpdCgksFsrksnLkrHirtH 23
                   +C+ Cg++F+ + +Lk+H++ +
  MDP0000175922 64 TCEECGTTFKKPAHLKQHLQIC 85
                   6*****************9987 PP
2zf-C2H215.93.6e-05155179123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    y C+  dC+ s++rk++L+rH+  H
  MDP0000175922 155 YICSvdDCHSSYRRKDHLTRHLLQH 179
                    89*******************9887 PP
3zf-C2H213.20.00026184209123
                    EEET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                    +kCp  +C++ F  + n krH +  H
  MDP0000175922 184 FKCPveNCNREFVFQGNIKRHVNElH 209
                    89*******************99888 PP
4zf-C2H2157e-05224248123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    ++C+   Cgk F+  s L++H  +H
  MDP0000175922 224 HVCQeiGCGKEFRYASRLRKHEESH 248
                    79*******************9988 PP
5zf-C2H217.11.5e-05315339223
                    EET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   2 kCp..dCgksFsrksnLkrHirt.H 23 
                    kC    C ++F++ksnL +H +  H
  MDP0000175922 315 KCDykGCLRTFTTKSNLXKHVKAvH 339
                    688889**************99877 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576672.11E-61783No hitNo description
SMARTSM00355471941IPR015880Zinc finger, C2H2-like
PROSITE profilePS501578.7256384IPR007087Zinc finger, C2H2
SMARTSM00355236383IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.606.5E-46484IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576674.24E-6151181No hitNo description
Gene3DG3DSA:3.30.160.606.9E-9151181IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.014155179IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.702155184IPR007087Zinc finger, C2H2
PROSITE patternPS000280157179IPR007087Zinc finger, C2H2
SuperFamilySSF576671.27E-5182209No hitNo description
Gene3DG3DSA:3.30.160.603.0E-4182209IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.762184214IPR007087Zinc finger, C2H2
SMARTSM003550.064184209IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280186209IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.3E-6219248IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.658224253IPR007087Zinc finger, C2H2
SMARTSM003550.011224248IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280226248IPR007087Zinc finger, C2H2
SMARTSM0035514256281IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280258281IPR007087Zinc finger, C2H2
SMARTSM0035516284305IPR015880Zinc finger, C2H2-like
SuperFamilySSF576671.25E-7296352No hitNo description
SMARTSM003550.0014314339IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.466314344IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.601.1E-6315339IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280316339IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.607.0E-5340368IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003555.8345371IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280347371IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 433 aa     Download sequence    Send to blast
MDKGAGEKEG PIVRDIRRHY CDYCGICRSK KSLIASHILS HHKEEMEMAD GDGGGDVGEE  60
NSNTCEECGT TFKKPAHLKQ HLQICVIFAS IESFKDISFA GINIYEKYTM DSVKHWIPHK  120
ELQNAIRFGL DGLVPGGRPP VKLHQANLSH ALRPYICSVD DCHSSYRRKD HLTRHLLQHQ  180
GKLFKCPVEN CNREFVFQGN IKRHVNELHI EDCPSADGGX QKQHVCQEIG CGKEFRYASR  240
LRKHEESHVK LDTVEAFCFE PGCMKHFTND QCLKVHIQSC HQHTTCEICG AKQLRQNMKR  300
HLLTHEXRXS IERIKCDYKG CLRTFTTKSN LXKHVKAVHL EHKPFVCSFS GCGMRFAYKH  360
VRDNHEKTGC HVYTHGDFEE ADEQFRSRPR GGRKRQCPDI PMLVRKRVTP PNRSAQESXY  420
LSWLRSQEDG DEH
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Both isoforms 1 and 2 transcripts are expressed in seedlings and both TFIIIA and TFIIIA-C are present at similar ratios in 10-day-old seedlings (at protein level). In correlation with the reorganization of 5S rDNA chromatin to a mature state, full-length isoform 1 protein TFIIIA with transcriptional activity accumulates and permits de novo transcription of 5S rRNA. Isoforms 1 and 2 transcripts accumulate in various tissues of the reproductive phase, including flowers and siliques, but only isoform 2 is present in mature seeds. In flowers, both TFIIIA and TFIIIA-C are present at similar ratios (at protein level). Very low amounts of TFIIIA are found in extracts from fresh siliques compared to TFIIIA-C. The amount of full-length TFIIIA protein progressively increases from fresh siliques to seeds concomitant with lower proportions of the shorter TFIIIA-C protein (at protein level) thus leading to 5S rRNA accumulation in the seed. {ECO:0000269|PubMed:22353599}.
UniprotTISSUE SPECIFICITY: Expressed in seedlings, flowers, siliques and seeds. {ECO:0000269|PubMed:22353599}.
Functional Description ? help Back to Top
Source Description
UniProtEssential protein (PubMed:22353599). Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599). Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599). {ECO:0000269|PubMed:12711688, ECO:0000269|PubMed:22353599}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028949415.10.0transcription factor IIIA-like isoform X2
RefseqXP_028949416.10.0transcription factor IIIA-like isoform X2
SwissprotQ84MZ41e-110TF3A_ARATH; Transcription factor IIIA
TrEMBLA0A498HTS70.0A0A498HTS7_MALDO; Uncharacterized protein
STRINGXP_008339227.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF30693370
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G72050.21e-112transcription factor IIIA