PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000169485
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family NAC
Protein Properties Length: 575aa    MW: 64844.8 Da    PI: 4.5207
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000169485genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM165.91.4e-51181442128
            NAM   2 ppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpk..kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk 95 
                    +pGfrFhPtdeelv +yLk+k+ +k+l++ +vi+e+d+yk++P +Lp+   +k+++++w+fFs+rd+ky++g r++rat++gyWkatgkd+++++ 
  MDP0000169485  18 APGFRFHPTDEELVLYYLKRKICKKRLKI-DVIAETDVYKWDPDELPElsLLKTGDRQWFFFSPRDRKYPNGGRSSRATRHGYWKATGKDRTIVC- 111
                    69***************************.99**************9445788899***************************************. PP

            NAM  96 kgelvglkktLvfykgrapkgektdWvmheyrl 128
                     ++ vglkktLv+ykgrap+ge+tdWvmhey+l
  MDP0000169485 112 YSRSVGLKKTLVYYKGRAPSGERTDWVMHEYTL 144
                    9999***************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019414.32E-5813167IPR003441NAC domain
PROSITE profilePS5100553.75117167IPR003441NAC domain
PfamPF023656.9E-2719144IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0070301Biological Processcellular response to hydrogen peroxide
GO:0005634Cellular Componentnucleus
GO:0005789Cellular Componentendoplasmic reticulum membrane
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 575 aa     Download sequence    Send to blast
MVTEDDSAAL FCDGHFAAPG FRFHPTDEEL VLYYLKRKIC KKRLKIDVIA ETDVYKWDPD  60
ELPELSLLKT GDRQWFFFSP RDRKYPNGGR SSRATRHGYW KATGKDRTIV CYSRSVGLKK  120
TLVYYKGRAP SGERTDWVMH EYTLDEEELK RCQNVQQYYA LYKVYKKSGP GPKNGEQYGA  180
PFREEDWVDD ESTVIKSAAD HQISVKQAVD VVSIDNVKVN GDVHYALNDI EEFMKQIADE  240
AVLPEMNGYG YTAPQVLSEE DTQSTLVDLY SREVICAEPV REFNPNVQQR NVDANFDFTQ  300
SSASQMQSYE ASEVTTAAPD IYDQDPPALH EEDFLEMDDL LGPEPTVPNT VNPVDDLQFG  360
ELDGLSEFDF YHDAAMFLHD LGPIDEGNVA HHQYMNSQGN NIVDQFEYHL QPNPVAENQV  420
NHLLNPESTQ INNQMWTNTE RAEPNQGSLS YSTPGVVYES SNFPSQATQN QSGNEAAGAT  480
SQFSSALWAF VESIPTTPAS ASENALVNRA FERMSSFSRL RINTASTTVA AGNDSETRRA  540
GRKRGFFFLP VLVALCAVFW VLIATLRPWG RSLST
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3ulx_A3e-481914417140Stress-induced transcription factor NAC1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
13544KRKICKKRLK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.150560.0bud| fruit| leaf| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, rosette leaves, cauline leaves, shoot apex, stems and flowers. {ECO:0000269|PubMed:17158162}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling. {ECO:0000269|PubMed:24045017}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00179DAPTransfer from AT1G34190Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold and drought stresses. {ECO:0000269|PubMed:17158162}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028965254.10.0NAC domain-containing protein 17-like
SwissprotQ9XIC51e-170NAC17_ARATH; NAC domain-containing protein 17
TrEMBLA0A498J0570.0A0A498J057_MALDO; Uncharacterized protein
STRINGXP_008381037.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF61313451
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34190.11e-160NAC domain containing protein 17
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Van Aken O, et al.
    Mitochondrial and Chloroplast Stress Responses Are Modulated in Distinct Touch and Chemical Inhibition Phases.
    Plant Physiol., 2016. 171(3): p. 2150-65
    [PMID:27208304]
  3. Van Aken O,Ford E,Lister R,Huang S,Millar AH
    Retrograde signalling caused by heritable mitochondrial dysfunction is partially mediated by ANAC017 and improves plant performance.
    Plant J., 2016. 88(4): p. 542-558
    [PMID:27425258]
  4. Hu Z, et al.
    Mitochondrial Defects Confer Tolerance against Cellulose Deficiency.
    Plant Cell, 2016. 28(9): p. 2276-2290
    [PMID:27543091]
  5. Chi YH, et al.
    The membrane-tethered NAC transcription factor, AtNTL7, contributes to ER-stress resistance in Arabidopsis.
    Biochem. Biophys. Res. Commun., 2017. 488(4): p. 641-647
    [PMID:28088515]
  6. Van Aken O,Pogson BJ
    Convergence of mitochondrial and chloroplastic ANAC017/PAP-dependent retrograde signalling pathways and suppression of programmed cell death.
    Cell Death Differ., 2017. 24(6): p. 955-960
    [PMID:28498364]
  7. Cheng P, et al.
    The ERA-Related GTPase AtERG2 Associated with Mitochondria 18S RNA Is Essential for Early Embryo Development in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 182
    [PMID:29497438]