PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Lsa011393
Organism
Lactuca sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; Lactucinae; Lactuca
Family bHLH
Protein Properties Length: 663aa    MW: 72807.2 Da    PI: 5.2427
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
gnl|UG|Lsa#S58694108PU_refUnigeneView CDS
PUT-187a-Lactuca_sativa-23416PU_unrefplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.41.1e-12477522454
                HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
        HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Lsa011393 477 NHVEAERQRREKLNQKFYALRAVVPNV-----SKMDKASLLGDAISYINDL 522
                799***********************6.....5****************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142158.2E-5474254IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.206473522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.81E-15476527No hitNo description
SuperFamilySSF474592.75E-18476544IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.6E-18477543IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000103.4E-10477522IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.2E-16479528IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 663 aa     Download sequence    Send to blast
MTDYRLPTAM NLWNADDNAM MDAFISSDMS SFWGNPTSTA APSAVPPASS SASTSTNDLH  60
KLAGESQPFN QDSLQQRLQG LIDNARDSWT YGIFWQSSAV DYTSPSFLGW GDGYYKGEIN  120
KQKTTTSVSS LAEQEHRKKV LRELNSLISG TQMPENEAVD EEVTDTEWFF LISMTQSFVN  180
GSGLPGQAMF SNQPVWIAGR ERLLASQCER ARQGEGFGLQ TIVCIPSTNG VLELGSTELI  240
FQSSDLMNEA RVLFNFSYSP PDLTPMNPNQ TPGGDTTDPS SLWLTDPVSS AAATTTTTTV  300
EMKDSVDVTA VAPPTTVIPS NNSVSKQISI DNPSCSSLTE NPSSVIHNSN RESIQNQGLF  360
GSRELNFSEF GSYDGSRNGN TSHSCKPESV ELLNFGESKK TFAGGEDNSN KKKKPHDGML  420
SFTSGTVIPP SETVKSGGAE LDPSIGREAE SRLVVEPEKR PKKRGRKPAN GREEPLNHVE  480
AERQRREKLN QKFYALRAVV PNVSKMDKAS LLGDAISYIN DLKSKLQNTE TGKEELKTQL  540
DAMKKEILLT KDSHQSSSST VSPPEDFKLT PTPNPNHPKI TDIDIDIKII GWDAMIRIQC  600
SKKNHPAARL MSALKDLDLD VHHASVSVVN DLMMQQATVK MGTRFYTQEQ LRLALTNRVS  660
DPR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A6e-67672571195Transcription factor MYC3
4rqw_B6e-67672571195Transcription factor MYC3
4rs9_A6e-67672571195Transcription factor MYC3
4yz6_A6e-67672571195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1458466KRPKKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_023750890.10.0transcription factor MYC2
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A2J6M6N90.0A0A2J6M6N9_LACSA; Uncharacterized protein
STRINGVIT_02s0012g01320.t010.0(Vitis vinifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-176bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]