PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID WALNUT_00021891-RA
Organism
Juglans regia
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Juglandaceae; Juglans
Family bHLH
Protein Properties Length: 684aa    MW: 74848.3 Da    PI: 5.5699
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
WALNUT_00021891-RAgenomeJHUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH37.35e-12505550454
                         HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                 HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                         +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  WALNUT_00021891-RA 505 NHVEAERQRREKLNQRFYSLRAVVPNV-----SKMDKASLLGDAILYINEL 550
                         799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142155.0E-5880261IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088816.736501550IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474594.19E-17504571IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000836.55E-14504555No hitNo description
Gene3DG3DSA:4.10.280.102.5E-17505571IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.1E-9505550IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003537.8E-16507556IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 684 aa     Download sequence    Send to blast
MHGMTDYRIT PPMNLWTSDE NPSVIESFMS SDLSFWPTPP PPPPQAQQLQ PQSSASTSAD  60
PTKALPQSQP SVALFNQETL QQRLQALIEG ARESWTYAIF WQSSYDYSGA SILGWGDGYY  120
KGDDDKSKGK AKTTSSAAEQ EHRKKVLREL NSLISDSAAS AADDSVDEEV TDTEWFFLVS  180
MTHSFVNGSG LAGQAFFNSS PVWVAGVDRL TDSPCERARQ GQVFGLQTIV CIPSANGVVE  240
LGSTELILHS SDLMNKVRVL FNFDSLEMGG SWPVTDQGEN DPSSLWINDP TPAAPMEIKD  300
SLNSTTVPSV PGTTNNGLQI SKAIQFENPS SSSLTENPSA IHMPSTNQSH QQRQQSQTQS  360
FFTRELNFSD YGYDGSSVVK NGNSNQLKPG SGEILNFGES KRSSYVSGHS QFVAPAVEEN  420
NKKKRTQSRG SNEEGMLSFT SGVILSNACV AKSSGGGGGG MADSEHSDLE ASVAKEVDSS  480
RVVDPEKRPR KRGRKPANGR EEPLNHVEAE RQRREKLNQR FYSLRAVVPN VSKMDKASLL  540
GDAILYINEL KGKLQSTESD KEDLQKQLEG LKKEFAGKDP RYPGSVPLPP LSDQDSKTSR  600
LIDLDIDVKI IGWDAMIRIQ SSKKNHPAAR LMAALKELDL DVHHASVSVV NDLMIQQATV  660
KMGSRFYTQE QLRLALSAKV GSSR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A2e-74752644195Transcription factor MYC3
4rqw_B2e-74752644195Transcription factor MYC3
4rs9_A2e-74752644195Transcription factor MYC3
4yz6_A2e-74752644195Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1486494KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018817566.10.0PREDICTED: transcription factor MYC2
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A2I4EDV00.0A0A2I4EDV0_JUGRE; transcription factor MYC2
STRINGVIT_02s0012g01320.t010.0(Vitis vinifera)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF29383364
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.10.0bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]