PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Gh_A05G3867
Organism
Gossypium hirsutum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium
Family C2H2
Protein Properties Length: 378aa    MW: 43253.3 Da    PI: 8.4359
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Gh_A05G3867genomeNAU-NBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H218.74.8e-0680101223
                  EETTTTEEESSHHHHHHHHHHT CS
      zf-C2H2   2 kCpdCgksFsrksnLkrHirtH 23 
                  +C+ Cg +F+ + +Lk+H+++H
  Gh_A05G3867  80 ECQECGATFRKPAHLKQHLQSH 101
                  5*******************99 PP
2zf-C2H2163.5e-05107131123
                  EEET..TTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                  ++C   dC+ s++rk++L+rH+  H
  Gh_A05G3867 107 FVCLvdDCHASYRRKDHLNRHLLQH 131
                  899999***************9887 PP
3zf-C2H212.50.00046136161123
                  EEET..TTTEEESSHHHHHHHHHH.T CS
      zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                  ++Cp  +C+  F  + n+krH +  H
  Gh_A05G3867 136 FSCPieNCNSKFAFQGNMKRHVKEfH 161
                  89********************9988 PP
4zf-C2H218.94e-06176200123
                  EEET..TTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                  y+C+   Cgk+F+  s L++H  +H
  Gh_A05G3867 176 YVCQevGCGKVFKFASKLRKHEDSH 200
                  99*******************9888 PP
5zf-C2H215.64.6e-05267291223
                  EET..TTTEEESSHHHHHHHHHH.T CS
      zf-C2H2   2 kCp..dCgksFsrksnLkrHirt.H 23 
                  kC    C  +Fs+ksnL++H +  H
  Gh_A05G3867 267 KCDfgGCLHTFSTKSNLRQHVKAvH 291
                  688889**************99877 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM00355283860IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.2243865IPR007087Zinc finger, C2H2
SMARTSM003550.01279101IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015713.71379106IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.604.7E-880105IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS00028081101IPR007087Zinc finger, C2H2
SuperFamilySSF576671.13E-992133No hitNo description
Gene3DG3DSA:3.30.160.603.3E-9106133IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.025107131IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.016107136IPR007087Zinc finger, C2H2
PROSITE patternPS000280109131IPR007087Zinc finger, C2H2
SuperFamilySSF576671.62E-5134162No hitNo description
Gene3DG3DSA:3.30.160.603.1E-5134162IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.066136161IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.058136166IPR007087Zinc finger, C2H2
PROSITE patternPS000280138161IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.5E-7170200IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576674.78E-5172200No hitNo description
SMARTSM003550.0089176200IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.907176205IPR007087Zinc finger, C2H2
PROSITE patternPS000280178200IPR007087Zinc finger, C2H2
SMARTSM0035511208233IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280210233IPR007087Zinc finger, C2H2
SMARTSM0035518236257IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.601.1E-5247288IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576671.92E-7248304No hitNo description
SMARTSM003550.0017266291IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015711.614266296IPR007087Zinc finger, C2H2
PROSITE patternPS000280268291IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.607.3E-5290318IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003555.2297323IPR015880Zinc finger, C2H2-like
PROSITE patternPS000280299323IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008097Molecular Function5S rRNA binding
GO:0046872Molecular Functionmetal ion binding
GO:0080084Molecular Function5S rDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 378 aa     Download sequence    Send to blast
MIICSENPLS SEKNKCNQMD EEKGERVSGP MFKDIRRYFC DHCGICRSKK SLITTHILTH  60
HPEKIDNGGK EEEEVSMSNE CQECGATFRK PAHLKQHLQS HSLERPFVCL VDDCHASYRR  120
KDHLNRHLLQ HQGKLFSCPI ENCNSKFAFQ GNMKRHVKEF HDEGSSSSDA ASQKQYVCQE  180
VGCGKVFKFA SKLRKHEDSH VKLDSVEAFC SEPSCMKYFT NEQCLKAHVQ SCHQYINCQI  240
CGAKQLKKNI KRHLRSHESG VASERIKCDF GGCLHTFSTK SNLRQHVKAV HEELKPFACS  300
FSGCGMRFSY KHVRDNHEKL ALHVYVPGDF IESDEQFQSR PRGGRKRTCP TVEMLIRKRV  360
APPQMDTMMD PGPIQGCS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1tf6_A2e-158322819155PROTEIN (TRANSCRIPTION FACTOR IIIA)
1tf6_D2e-158322819155PROTEIN (TRANSCRIPTION FACTOR IIIA)
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Both isoforms 1 and 2 transcripts are expressed in seedlings and both TFIIIA and TFIIIA-C are present at similar ratios in 10-day-old seedlings (at protein level). In correlation with the reorganization of 5S rDNA chromatin to a mature state, full-length isoform 1 protein TFIIIA with transcriptional activity accumulates and permits de novo transcription of 5S rRNA. Isoforms 1 and 2 transcripts accumulate in various tissues of the reproductive phase, including flowers and siliques, but only isoform 2 is present in mature seeds. In flowers, both TFIIIA and TFIIIA-C are present at similar ratios (at protein level). Very low amounts of TFIIIA are found in extracts from fresh siliques compared to TFIIIA-C. The amount of full-length TFIIIA protein progressively increases from fresh siliques to seeds concomitant with lower proportions of the shorter TFIIIA-C protein (at protein level) thus leading to 5S rRNA accumulation in the seed. {ECO:0000269|PubMed:22353599}.
UniprotTISSUE SPECIFICITY: Expressed in seedlings, flowers, siliques and seeds. {ECO:0000269|PubMed:22353599}.
Functional Description ? help Back to Top
Source Description
UniProtEssential protein (PubMed:22353599). Isoform 1 is a transcription activator the binds both 5S rDNA and 5S rRNA and stimulates the transcription of 5S rRNA gene (PubMed:12711688, PubMed:22353599). Isoform 1 regulates 5S rRNA levels during development (PubMed:22353599). {ECO:0000269|PubMed:12711688, ECO:0000269|PubMed:22353599}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00229DAPTransfer from AT1G72050Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012442876.10.0PREDICTED: putative zinc finger protein 66 isoform X1
SwissprotQ84MZ41e-151TF3A_ARATH; Transcription factor IIIA
TrEMBLA0A0D2QEX00.0A0A0D2QEX0_GOSRA; Uncharacterized protein
STRINGGorai.009G128000.10.0(Gossypium raimondii)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM47142852
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G72050.21e-154transcription factor IIIA