PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

orange1.1g046437m

Common Name

CISIN_1g046437mg

Organism

Citrus sinensis

Taxonomic ID

2711

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus

Family

NAC

Protein Properties

Length: 125aa MW: 14770.5 Da PI: 9.8728

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
orange1.1g046437m	genome	ICGC	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	54.3	4.7e-17	61	125	2	66
NAM 2 ppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvka.eekewyfFskrdk 66 ppG+rF+P+d el+v+yL++k +++l+ + ikev++yk++P +L +k+k +e+ewyfF++r++ orange1.1g046437m 61 PPGYRFKPHDIELLVHYLRRKRMNEPLPP-NRIKEVHLYKFNPDTLSEKYKPfGENEWYFFTPRER 125 9***********************999.77**********9555444899****9975 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.83E-20	59	125	IPR003441	NAC domain
PROSITE profile	PS51005	22.711	60	125	IPR003441	NAC domain
Pfam	PF02365	4.0E-9	61	124	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 125 aa Download sequence Send to blast
MPDQQQGDKD QDPNGQDRNG KNPNGQGPKG KRPIDHTRDA SPPVRNRMNA AKGPEFDDNF 60 PPGYRFKPHD IELLVHYLRR KRMNEPLPPN RIKEVHLYKF NPDTLSEKYK PFGENEWYFF 120 TPRER

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3ulx_A	3e-16	48	125	3	79	Stress-induced transcription factor NAC1
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Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed at the base of the inflorescence meristem and at late stages of development in petals and stamens. Up-regulated during leaf senescence. {ECO:0000269\|PubMed:16640597, ECO:0000269\|PubMed:9489703}.
Uniprot	DEVELOPMENTAL STAGE: Increased expression during grain maturation and senescence. Not induced during flower development. {ECO:0000269\|PubMed:17124321, ECO:0000269\|PubMed:22278768}.
Uniprot	TISSUE SPECIFICITY: Expressed in senescing leaves, petals and sepals. {ECO:0000269\|PubMed:16640597}.
Uniprot	TISSUE SPECIFICITY: Highest expression in flag leaves. Expressed in green spikes, peduncles and stamens. {ECO:0000269\|PubMed:17124321, ECO:0000269\|PubMed:22278768}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds to, and transactivates the promoter of the abscisic aldehyde oxidase AAO3. Promotes chlorophyll degradation in leaves by enhancing transcription of AAO3, which leads to increased levels of the senescence-inducing hormone abscisic acid (ABA) (PubMed:25516602). Involved in the control of dehydration in senescing leaves. Binds to the DNA sequence 5'-CACGTAAGT-3' of SAG113 promoter. SAG113 acts as negative regulator of ABA signaling for stomatal closure in leaves, and controls water loss during leaf senescence (PubMed:22184656). Transcription factor of the NAC family involved in senescence. May function in the transition between active cell division and cell expansion (PubMed:16640597). Required for normal seed development and morphology (PubMed:18849494). {ECO:0000269\|PubMed:16640597, ECO:0000269\|PubMed:18849494, ECO:0000269\|PubMed:22184656, ECO:0000269\|PubMed:25516602}.
UniProt	Transcription factor of the NAC family associated with the grain protein content (GPC). Accelerates senescence and increases nutrient remobilization from leaves to developing grains. The tetraploid cultivated wheat (T.durum) contains one additional gene coding for a functional protein (NAM-A1) and one extra pseudogene (NAM-B1) (PubMed:17124321). Plays a weaker role in terminal senescence than NAM-A1. {ECO:0000269\|PubMed:17124321, ECO:0000269\|PubMed:22278768}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by the heterodimer APETALA3 (AP3)/PISTILLATA (PI) (PubMed:9489703). Induced by senescence (PubMed:22184656, PubMed:24659488, PubMed:25516602). Induced by abscisic acid (ABA) (PubMed:22184656, PubMed:25516602). Induced by ethylene (PubMed:25516602). {ECO:0000269\|PubMed:22184656, ECO:0000269\|PubMed:24659488, ECO:0000269\|PubMed:25516602, ECO:0000269\|PubMed:9489703}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006453417.1	3e-84	NAC transcription factor 25
Swissprot	A0SPJ6	2e-18	NAMB2_TRITD; NAC transcription factor NAM-B2
Swissprot	O49255	2e-18	NAC29_ARATH; NAC transcription factor 29
TrEMBL	A0A067D6B5	6e-86	A0A067D6B5_CITSI; Uncharacterized protein (Fragment)
TrEMBL	V4UKJ4	6e-83	V4UKJ4_9ROSI; Uncharacterized protein
STRING	XP_006474627.1	1e-83	(Citrus sinensis)
STRING	XP_006453417.1	1e-83	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM17542	3	10

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G69490.1	2e-20	NAC-like, activated by AP3/PI

Link Out ? help Back to Top
Phytozome	orange1.1g046437m

Publications ? help Back to Top
Uauy C,Distelfeld A,Fahima T,Blechl A,Dubcovsky J A NAC Gene regulating senescence improves grain protein, zinc, and iron content in wheat. Science, 2006. 314(5803): p. 1298-301 [PMID:17124321] Zhang K,Gan SS An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves. Plant Physiol., 2012. 158(2): p. 961-9 [PMID:22184656] Zhang K,Halitschke R,Yin C,Liu CJ,Gan SS Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating salicylic acid catabolism. Proc. Natl. Acad. Sci. U.S.A., 2013. 110(36): p. 14807-12 [PMID:23959884] Shinozaki Y, et al. Expression of an AtNAP gene homolog in senescing morning glory (Ipomoea nil) petals of two cultivars with a different flower life span. J. Plant Physiol., 2014. 171(8): p. 633-8 [PMID:24709156] Xiao D, et al. SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis. Plant Physiol., 2015. 169(2): p. 1275-91 [PMID:26304848] Sakuraba Y,Han SH,Lee SH,Hörtensteiner S,Paek NC Arabidopsis NAC016 promotes chlorophyll breakdown by directly upregulating STAYGREEN1 transcription. Plant Cell Rep., 2016. 35(1): p. 155-66 [PMID:26441053] Seok HY, et al. Arabidopsis AtNAP functions as a negative regulator via repression of AREB1 in salt stress response. Planta, 2017. 245(2): p. 329-341 [PMID:27770200]