PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID orange1.1g018790m
Common NameCISIN_1g018790mg
Organism
Citrus sinensis
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family E2F/DP
Protein Properties Length: 351aa    MW: 39298.1 Da    PI: 9.098
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
orange1.1g018790mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.78.4e-232489171
            E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                       rkeksL+ll++kflkl+++   + + l+++a++L    v  +rRRiYD++N+Le+++++++++kn ++w+g
  orange1.1g018790m 24 RKEKSLGLLCSKFLKLYNRDGVESIGLDDAASRL---GV--ERRRIYDVVNILESIGVVARQAKNLYSWQG 89
                       79*****************999************...**..****************************98 PP
2E2F_TDP28.23e-09148194238
            E2F_TDP   2 keksLrlltqkflkllekseegivtlnevakeLvse..........d 38 
                        +eksL+lltq+f+kl+ +s+ +++tl+++a +L+ +           
  orange1.1g018790m 148 REKSLWLLTQNFVKLFLCSDVDMITLDSAAMALLGDsnnstamrksR 194
                        79*******************************99987766555440 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.9E-252291IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.53E-162387IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.3E-272489IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.8E-202589IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.3E-5145180IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.7E-5147202IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 351 aa     Download sequence    Send to blast
MSSSSSSAFG FREAEPDGKQ FYSRKEKSLG LLCSKFLKLY NRDGVESIGL DDAASRLGVE  60
RRRIYDVVNI LESIGVVARQ AKNLYSWQGF DAIPEALEVL KEEGLRENFN INGCTNSGNV  120
LNDNENEGST CTVTDGQDSS SSKIESKREK SLWLLTQNFV KLFLCSDVDM ITLDSAAMAL  180
LGDSNNSTAM RKSRKPAFRW LGWKGNPCNR SAGFLDLNEP KKRVFGTDIT NLRLKKNKVD  240
SLTEKKSNPK LNVPKYFKHC NEESNPDESR LEQHSKHKSK GFVYGPFTPA SISGIHDSRS  300
KNTKQVLDFA SLASTFRPKY HNEAVNGLFG HYVEAWKSWY AEVGDKEQKT *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A9e-25231853190Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in mid-S phase. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:15308755}.
UniprotTISSUE SPECIFICITY: High expression in young cotyledons and leaves, hypocotyls, shoot apical meristem, roots and mature pollen grains, moderate in developing trichomes, flowers and at early stages of developing anthers, and barely detectable in mature leaves. Not detected in primary root meristem, emerging lateral roots, pistils, developing embryos and siliques. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006446434.10.0E2F transcription factor-like E2FF
RefseqXP_024047120.10.0E2F transcription factor-like E2FF
SwissprotQ8RWL01e-106E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A067FJK30.0A0A067FJK3_CITSI; Uncharacterized protein
STRINGXP_006446434.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-101DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]