PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Cucsa.197250.1
Organism
Cucumis sativus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis
Family E2F/DP
Protein Properties Length: 319aa    MW: 36333.7 Da    PI: 10.5293
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Cucsa.197250.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP672.4e-211981171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll++k   l+ + + + ++l+++a++L    v  +rRRiYDi+NVLe+++++ +k+kn++rw+g
  Cucsa.197250.1 19 RKQKSLGLLCSK---LYDRDDIQLISLDNAASRL---GV--ERRRIYDIVNVLESVGILCRKAKNQYRWIG 81
                    79**********...9998888************...**..****************************98 PP
2E2F_TDP73.13e-2395175171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL lltq+f+kl+ +s++  ++l+e+ak L+ +      ++ k+RR+YDi+NVL al+liek     ++k++++w g
  Cucsa.197250.1  95 RREKSLALLTQNFVKLFVCSSAHLISLDEAAKLLLGNgesvsIMRSKVRRLYDIANVLAALHLIEKtqtdgTRKPAFKWLG 175
                     689********************************999***9999*************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.3E-221582IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.1E-231981IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.8E-182081IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.54E-132282IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.4E-2193176IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.1E-2795175IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.91E-1397176IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023196.5E-1897175IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 319 aa     Download sequence    Send to blast
MAANLHLPLP DSSSNAYSRK QKSLGLLCSK LYDRDDIQLI SLDNAASRLG VERRRIYDIV  60
NVLESVGILC RKAKNQYRWI GYSGIPKALR KLKNRREKSL ALLTQNFVKL FVCSSAHLIS  120
LDEAAKLLLG NGESVSIMRS KVRRLYDIAN VLAALHLIEK TQTDGTRKPA FKWLGWRSLV  180
ENCRPGKLLR CDSNKRSFGS DITNNHLKRN RLPYSFDLNK SPNSQQQRHV QLETCGVEVT  240
GGELEKDLNS KSFKFGPFSP SVRVEARASK IEAKRSRNNW VSLASTYCPQ YQNQALRDLF  300
SHYKEAWKLW YSEKKTNP*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-141899391Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
18996RKLKNRRE
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818130.0LN681813.1 Cucumis melo genomic scaffold, anchoredscaffold00030.
GenBankLN7132560.0LN713256.1 Cucumis melo genomic chromosome, chr_2.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011659112.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8RWL02e-77E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A1S3BVG70.0A0A1S3BVG7_CUCME; E2F transcription factor-like E2FE isoform X3
STRINGXP_004166228.10.0(Cucumis sativus)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.18e-74DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]