PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ciclev10011915m
Common NameCICLE_v10011915mg
Organism
Citrus clementina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus
Family MYB
Protein Properties Length: 394aa    MW: 44703.9 Da    PI: 9.7053
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ciclev10011915mgenomeICGCView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding53.46e-17453148
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHT..TTS-HHHHHHHHHHHT CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmg..kgRtlkqcksrwqkyl 48
                     r+rW +eEd +l+ +vkq+G++ W++I+++mg  ++R +k+c +rw +yl
  Ciclev10011915m  4 RQRWQPEEDAILKAYVKQYGPKEWNLISQRMGktLNRDPKSCLERWKNYL 53
                     89**********************************************97 PP
2Myb_DNA-binding33.97.4e-1159103147
                      TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS
  Myb_DNA-binding   1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 
                      +g+ ++eE+ l + + +++G++ Wk+Ia++++ gRt+k +  +w  +
  Ciclev10011915m  59 KGSLSPEEQSLVISLQAKYGNK-WKKIASEVP-GRTAKRLGKWWEVF 103
                      57789*****************.*********.*****999999766 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5129424.052157IPR017930Myb domain
SMARTSM007171.6E-14355IPR001005SANT/Myb domain
SuperFamilySSF466892.01E-22498IPR009057Homeodomain-like
CDDcd001671.15E-9653No hitNo description
Gene3DG3DSA:1.10.10.607.0E-21660IPR009057Homeodomain-like
PfamPF139211.1E-15769No hitNo description
SMARTSM007179.4E-1058106IPR001005SANT/Myb domain
PROSITE profilePS5129417.32658108IPR017930Myb domain
Gene3DG3DSA:1.10.10.602.8E-1561108IPR009057Homeodomain-like
CDDcd001673.00E-663104No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 394 aa     Download sequence    Send to blast
MKERQRWQPE EDAILKAYVK QYGPKEWNLI SQRMGKTLNR DPKSCLERWK NYLKPGIKKG  60
SLSPEEQSLV ISLQAKYGNK WKKIASEVPG RTAKRLGKWW EVFKEKQLKQ LHKEKQRREY  120
SDQQQEGNVP VVGLGSGSCS SPEKVAQGRY DHILETFAEK YVQPKLFAMQ ALNLNLNPVP  180
ANAIMPNLPL GGADPEPVLS LGSGPTWMNN HNHNHNHHTS GSSLTSSTSS TTTASPSVSL  240
SLSPSEPGIE LGDMNPVARF MPGPQVGTLV QYCKELEEGR QSWVQHKKEA TWRLSRLEQQ  300
LESEKARKRR EKMDEIETKI RALREEELSH LGRIESEYKE QLSALQRDAE SKEAKLMEAW  360
CSRHVKLLKL VEQIGVHQSS TSHGFCVVPK DMH*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3zqc_A4e-15111309127MYB3
3zqc_D4e-15111309127MYB3
3zqc_G4e-15111309127MYB3
3zqc_J4e-15111309127MYB3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1306311RKRREK
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Preferential expression in young and immature plant tissues. In embryos, expressed from the late globular stage onwards. After germination, detected in leaf founder cells and on flowering, in primordia of all floral organs.
UniprotTISSUE SPECIFICITY: Expressed in roots, stems, leaves, flowers, siliques and in lateral organ promordia (PubMed:17559509). Found in the inner domain between the adaxial and abaxial domains of leaves (PubMed:17559509). Expressed in the phloem tissues of leaves, cotyledons, hypocotyls, and roots (PubMed:21950734). {ECO:0000269|PubMed:17559509, ECO:0000269|PubMed:21950734}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor required for normal cell differentiation. Positively regulates LATERAL ORGAN BOUNDARIES (LOB) within the shoot apex, and the class III HD-ZIP genes REV, PHB, and PHV. Interacts directly with ASYMMETRIC LEAVES 2 (LBD6/AS2) to repress the knox homeobox genes BP/KNAT1, KNAT2, and KNAT6 and the abaxial determinants ARF3/ETT, KAN2 and YAB5. May act in parallel with the RDR6-SGS3-AGO7 pathway, an endogenous RNA silencing pathway, to regulate the leaf morphogenesis (PubMed:11076771, PubMed:11140682, PubMed:11882937, PubMed:12750468, PubMed:16006579, PubMed:16699177, PubMed:17395603, PubMed:17559509, PubMed:23271976). Binds directly to KNAT1, KNAT2, and KNATM chromatin, regulating leaf development (PubMed:23271976). LBD6 is required for this binding (PubMed:23271976). Positive regulator of flowering that binds to the promoter of FT (PubMed:21950734). Regulates FT expression by forming a functional complex with CO (PubMed:21950734). Involved in leaf polarity establishment by functioning cooperatively with NUCL1 to repress abaxial genes ARF3, ARF4, KAN1, KAN2, YAB1 and YAB5, and the knox homeobox genes KNAT1, KNAT2, KNAT6, and STM to promote adaxial development in leaf primordia at shoot apical meristems at high temperatures (PubMed:27334696). {ECO:0000269|PubMed:11076771, ECO:0000269|PubMed:11140682, ECO:0000269|PubMed:11882937, ECO:0000269|PubMed:12750468, ECO:0000269|PubMed:16006579, ECO:0000269|PubMed:16699177, ECO:0000269|PubMed:17395603, ECO:0000269|PubMed:17559509, ECO:0000269|PubMed:23271976, ECO:0000269|PubMed:27334696}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Circadian-regulation with an afternoon peak in long days and with a broad night peak in short days (PubMed:21950734). Expression of AS1 in stem cells of the shoot apical meristem is prevented by SHOOT MERISTEMLESS (STM). Expression is activated by GTE6 during leaf morphogenesis (PubMed:16166385). {ECO:0000269|PubMed:16166385, ECO:0000269|PubMed:21950734}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankEF5922101e-55EF592210.1 Mangifera indica clone MiIIHR30 microsatellite sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006430817.10.0transcription factor AS1
SwissprotO809311e-103AS1_ARATH; Transcription factor AS1
TrEMBLV4STI90.0V4STI9_9ROSI; Uncharacterized protein
STRINGXP_006430817.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM61862740
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G37630.17e-58MYB family protein
Publications ? help Back to Top
  1. Hazen SP, et al.
    Rapid array mapping of circadian clock and developmental mutations in Arabidopsis.
    Plant Physiol., 2005. 138(2): p. 990-7
    [PMID:15908595]
  2. Pinon V, et al.
    Three PIGGYBACK genes that specifically influence leaf patterning encode ribosomal proteins.
    Development, 2008. 135(7): p. 1315-24
    [PMID:18305008]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Zhou F,Roy B,Dunlap JR,Enganti R,von Arnim AG
    Translational control of Arabidopsis meristem stability and organogenesis by the eukaryotic translation factor eIF3h.
    PLoS ONE, 2014. 9(4): p. e95396
    [PMID:24736281]
  5. Scofield S,Dewitte W,Murray JA
    STM sustains stem cell function in the Arabidopsis shoot apical meristem and controls KNOX gene expression independently of the transcriptional repressor AS1.
    Plant Signal Behav, 2018.
    [PMID:24776954]
  6. Ivanova A, et al.
    A Functional Antagonistic Relationship between Auxin and Mitochondrial Retrograde Signaling Regulates Alternative Oxidase1a Expression in Arabidopsis.
    Plant Physiol., 2014. 165(3): p. 1233-1254
    [PMID:24820025]
  7. Machida C,Nakagawa A,Kojima S,Takahashi H,Machida Y
    The complex of ASYMMETRIC LEAVES (AS) proteins plays a central role in antagonistic interactions of genes for leaf polarity specification in Arabidopsis.
    Wiley Interdiscip Rev Dev Biol, 2015 Nov-Dec. 4(6): p. 655-71
    [PMID:26108442]
  8. Kaurilind E,Xu E,Brosché M
    A genetic framework for H2O2 induced cell death in Arabidopsis thaliana.
    BMC Genomics, 2015. 16: p. 837
    [PMID:26493993]
  9. Mateo-Bonmatí E, et al.
    Plastid control of abaxial-adaxial patterning.
    Sci Rep, 2015. 5: p. 15975
    [PMID:26522839]
  10. Rast-Somssich MI, et al.
    Alternate wiring of a KNOXI genetic network underlies differences in leaf development of A. thaliana and C. hirsuta.
    Genes Dev., 2015. 29(22): p. 2391-404
    [PMID:26588991]
  11. Guzmán-López JA,Abraham-Juárez MJ,Lozano-Sotomayor P,de Folter S,Simpson J
    Arabidopsis thaliana gonidialess A/Zuotin related factors (GlsA/ZRF) are essential for maintenance of meristem integrity.
    Plant Mol. Biol., 2016. 91(1-2): p. 37-51
    [PMID:26826012]
  12. Li Z, et al.
    Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
    J Integr Plant Biol, 2016. 58(12): p. 959-970
    [PMID:27273574]
  13. Matsumura Y, et al.
    A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis.
    Biol Open, 2016. 5(7): p. 942-54
    [PMID:27334696]
  14. Silverblatt-Buser EW,Frick MA,Rabeler C,Kaplinsky NJ
    Genetic Interactions Between BOB1 and Multiple 26S Proteasome Subunits Suggest a Role for Proteostasis in Regulating Arabidopsis Development.
    G3 (Bethesda), 2018. 8(4): p. 1379-1390
    [PMID:29487187]
  15. Tsukaya H,Uchimiya H
    Genetic analyses of the formation of the serrated margin of leaf blades in Arabidopsis: combination of a mutational analysis of leaf morphogenesis with the characterization of a specific marker gene expressed in hydathodes and stipules.
    Mol. Gen. Genet., 1997. 256(3): p. 231-8
    [PMID:9393447]