PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_9982_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family NAC
Protein Properties Length: 359aa    MW: 41035.8 Da    PI: 4.5648
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_9982_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM170.74.7e-53101362128
            NAM   2 ppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLp.k.kvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk 95 
                    ppGfrFhPtdeelv +yLkkk+ ++k+++ ++i+e+d+yk++P++Lp +  +k+++++w+fFs+rd+ky++g r+nrat++gyWkatgkd+ +++ 
  Neem_9982_f_1  10 PPGFRFHPTDEELVLYYLKKKICKRKMKM-NIIAETDVYKWDPEELPgQsLLKTGDRQWFFFSPRDRKYPNGARSNRATRQGYWKATGKDRIITC- 103
                    8****************************.89**************96347788999**************************************. PP

            NAM  96 kgelvglkktLvfykgrapkgektdWvmheyrl 128
                     +++vglkktLvfy+grap+ge+tdWvmhey+l
  Neem_9982_f_1 104 CSRNVGLKKTLVFYRGRAPNGERTDWVMHEYTL 136
                    999****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019415.75E-594159IPR003441NAC domain
PROSITE profilePS5100554.7599159IPR003441NAC domain
PfamPF023654.8E-2810136IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0070301Biological Processcellular response to hydrogen peroxide
GO:0005634Cellular Componentnucleus
GO:0005789Cellular Componentendoplasmic reticulum membrane
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MKVTPENVWP PGFRFHPTDE ELVLYYLKKK ICKRKMKMNI IAETDVYKWD PEELPGQSLL  60
KTGDRQWFFF SPRDRKYPNG ARSNRATRQG YWKATGKDRI ITCCSRNVGL KKTLVFYRGR  120
APNGERTDWV MHEYTLDEEE LKRCQNVKDY YALYKAFKKS GPGPKNGEQY GAPFKEEDWV  180
DDEDLDASKT GEQEIPANQP NEVAAIENVK PDNQVSSVLD DFEEFINQLA AEPLPTEPQI  240
RSAYEAPQVG NVVGEEQTQS TLVNPSSREV MFSKSISVCN EQASFEFTES TSPNLHLHEA  300
SEVTSAPNNW EPALEICDEG FLEMDDLIGP EPTPAEKPVE NLQFDEFGAL RNYYQCAGK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ut4_A2e-491016518171NO APICAL MERISTEM PROTEIN
1ut4_B2e-491016518171NO APICAL MERISTEM PROTEIN
1ut7_A2e-491016518171NO APICAL MERISTEM PROTEIN
1ut7_B2e-491016518171NO APICAL MERISTEM PROTEIN
3swm_A2e-491016521174NAC domain-containing protein 19
3swm_B2e-491016521174NAC domain-containing protein 19
3swm_C2e-491016521174NAC domain-containing protein 19
3swm_D2e-491016521174NAC domain-containing protein 19
3swp_A2e-491016521174NAC domain-containing protein 19
3swp_B2e-491016521174NAC domain-containing protein 19
3swp_C2e-491016521174NAC domain-containing protein 19
3swp_D2e-491016521174NAC domain-containing protein 19
4dul_A2e-491016518171NAC domain-containing protein 19
4dul_B2e-491016518171NAC domain-containing protein 19
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
12835KKICKRKM
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (By similarity). Transcriptional activator that promotes leaf senescence by up-regulating senescence-associated genes in response to developmental and stress-induced senescence signals. Functions in salt and oxidative stress-responsive signaling pathways. Binds to the promoter of NAC029/NAP and NAC059/ORS1 genes (PubMed:23926065). {ECO:0000250|UniProtKB:Q949N0, ECO:0000269|PubMed:23926065}.
UniProtTranscriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP). Transcriptional activator that acts as positive regulator of AOX1A during mitochondrial dysfunction. Binds directly to AOX1A promoter. Mediates mitochondrial retrograde signaling. {ECO:0000269|PubMed:24045017}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00179DAPTransfer from AT1G34190Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold and drought stresses. {ECO:0000269|PubMed:17158162}.
UniProtINDUCTION: By cold, salt, drought stress and methyl methanesulfonate (MMS) treatment. {ECO:0000269|PubMed:17158162}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLN6818931e-31LN681893.1 Cucumis melo genomic scaffold, anchoredscaffold00055.
GenBankLN7132631e-31LN713263.1 Cucumis melo genomic chromosome, chr_9.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006434569.10.0NAC domain-containing protein 17
SwissprotA4FVP61e-112NAC16_ARATH; NAC domain-containing protein 16
SwissprotQ9XIC51e-112NAC17_ARATH; NAC domain-containing protein 17
TrEMBLA0A2H5NJ500.0A0A2H5NJ50_CITUN; Uncharacterized protein
STRINGXP_006434569.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM28122667
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34180.11e-106NAC domain containing protein 16
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Sakuraba Y,Han SH,Lee SH,Hörtensteiner S,Paek NC
    Arabidopsis NAC016 promotes chlorophyll breakdown by directly upregulating STAYGREEN1 transcription.
    Plant Cell Rep., 2016. 35(1): p. 155-66
    [PMID:26441053]
  4. Van Aken O, et al.
    Mitochondrial and Chloroplast Stress Responses Are Modulated in Distinct Touch and Chemical Inhibition Phases.
    Plant Physiol., 2016. 171(3): p. 2150-65
    [PMID:27208304]
  5. Van Aken O,Ford E,Lister R,Huang S,Millar AH
    Retrograde signalling caused by heritable mitochondrial dysfunction is partially mediated by ANAC017 and improves plant performance.
    Plant J., 2016. 88(4): p. 542-558
    [PMID:27425258]
  6. Hu Z, et al.
    Mitochondrial Defects Confer Tolerance against Cellulose Deficiency.
    Plant Cell, 2016. 28(9): p. 2276-2290
    [PMID:27543091]
  7. Chi YH, et al.
    The membrane-tethered NAC transcription factor, AtNTL7, contributes to ER-stress resistance in Arabidopsis.
    Biochem. Biophys. Res. Commun., 2017. 488(4): p. 641-647
    [PMID:28088515]
  8. Van Aken O,Pogson BJ
    Convergence of mitochondrial and chloroplastic ANAC017/PAP-dependent retrograde signalling pathways and suppression of programmed cell death.
    Cell Death Differ., 2017. 24(6): p. 955-960
    [PMID:28498364]
  9. Cheng P, et al.
    The ERA-Related GTPase AtERG2 Associated with Mitochondria 18S RNA Is Essential for Early Embryo Development in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 182
    [PMID:29497438]