PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_617_f_5
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family MYB
Protein Properties Length: 403aa    MW: 46176.4 Da    PI: 8.0878
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_617_f_5genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding43.19.9e-14114159146
                      TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
  Myb_DNA-binding   1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 
                      +g+W +eEde l++ vk++G+++W++I ++  + Rt+k+c++rw +
     Neem_617_f_5 114 KGPWKAEEDEVLINHVKKYGPRDWSSIRSKGLLQRTGKSCRLRWVN 159
                      79*************************8887799**********87 PP
2Myb_DNA-binding41.92.4e-13170209344
                      SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
  Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                      +++ eE+ + +++ +++G++ W++Ia +++ gRt++++k++w
     Neem_617_f_5 170 KFSLEEERIVIELQAEFGNK-WARIATYLP-GRTDNDVKNFW 209
                      799*****************.*********.*********** PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.602.8E-21109162IPR009057Homeodomain-like
PROSITE profilePS5129421.904109165IPR017930Myb domain
SuperFamilySSF466894.3E-28112209IPR009057Homeodomain-like
SMARTSM007174.6E-11113163IPR001005SANT/Myb domain
CDDcd001678.94E-11116161No hitNo description
PfamPF139216.6E-12117167No hitNo description
Gene3DG3DSA:1.10.10.607.9E-18163215IPR009057Homeodomain-like
PROSITE profilePS5129418.362166217IPR017930Myb domain
SMARTSM007171.2E-12167215IPR001005SANT/Myb domain
CDDcd001676.78E-10170209No hitNo description
PfamPF002493.5E-12170209IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0048235Biological Processpollen sperm cell differentiation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 403 aa     Download sequence    Send to blast
MYKNFSVPSA IGGIAGSRCS HPILICRPTN GPPRAFYKSE SNHYLIPEHV LCFFAHSKVR  60
GYRVIKVISY PFECEKILGM WEYLWRVVGV TVLTVTFNSE KKKAMDGKRE EIRKGPWKAE  120
EDEVLINHVK KYGPRDWSSI RSKGLLQRTG KSCRLRWVNK LRPNLKNGCK FSLEEERIVI  180
ELQAEFGNKW ARIATYLPGR TDNDVKNFWS SRQKRLARIL QNSATPSSSN SKSHKIKKEI  240
PEFQGIHPLE DPKLKALMEE ESSSSKAQLA DMVNPKLHHF GANHSHLQLT PYENDPYTES  300
HLQIHFPQIS QPQQDLIFSP ESQELLARLE DPYFFDVFGS VDAPELSNEV QLPVEQPPLK  360
PETSCRNGGK DGNDKSVNPD AFFDDFPTDM FDHIEPLPSP SDW
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C2e-2711121524126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP2028714e-53KP202871.1 Jatropha curcas MYB125 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006445379.11e-146transcription factor DUO1
RefseqXP_006464457.11e-146transcription factor DUO1
SwissprotA0A178VEK77e-95DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A2H5NP351e-145A0A2H5NP35_CITUN; Uncharacterized protein
STRINGXP_006464457.11e-146(Citrus sinensis)
STRINGXP_006445379.11e-146(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM65512842
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.13e-96MYB family protein
Publications ? help Back to Top
  1. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  2. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  3. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]