PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_5997_f_2
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family HSF
Protein Properties Length: 606aa    MW: 66959.6 Da    PI: 5.3132
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_5997_f_2genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind94.21.5e-291122362102
                    HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTT....................... CS
   HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekksks....................... 74 
                    Fl+k++++++d++l+ +isw ++g+sfvv+d+ efa+ +Lp+ Fkh+nf+SFvRQLn+Y    v+++                             
  Neem_5997_f_2 112 FLSKTFDLVDDRSLDPIISWGSTGESFVVWDPVEFARLILPRNFKHNNFSSFVRQLNTYVGITVTQPLLAAVIclsvlvykllcwickkkmkgfrk 207
                    9**********************************************************88888888766444899****9999999988777665 PP

                    .XTTSEEEEESXXXXXXXXXXXXXXXXXX CS
   HSF_DNA-bind  75 .kekiweFkhksFkkgkkellekikrkks 102
                     +++ weF+++ F++gk++ll++i+r+k 
  Neem_5997_f_2 208 iDTDRWEFANEAFQRGKRHLLKNIQRRKA 236
                    449************************86 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF467851.9E-30107234IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004151.1E-44108234IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.10.10.102.3E-33109234IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF004474.6E-27112234IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000563.6E-12112135IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000563.6E-12150162IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000563.6E-12163175IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009408Biological Processresponse to heat
GO:0010200Biological Processresponse to chitin
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 606 aa     Download sequence    Send to blast
MDREEPNYPK SPPTTTLGTS SSSSSSQVPL ETEPETMRGV MGTQQFSSFS MENIALPTSP  60
LSPFTELEGF SSFATTPVAE QPPGPPASSS SVMNIVVPHP LESLQGNPVP PFLSKTFDLV  120
DDRSLDPIIS WGSTGESFVV WDPVEFARLI LPRNFKHNNF SSFVRQLNTY VGITVTQPLL  180
AAVICLSVLV YKLLCWICKK KMKGFRKIDT DRWEFANEAF QRGKRHLLKN IQRRKAPQSQ  240
QIGSYIGPST EAGKFAVQAD IEKLRKERSV LMQEVVELQQ QHHGTARHMD IVNQRLQAAE  300
QRQKQMVSFL AKLLQNPEFV ARLKQKKEQG DIGSSRTRRK FVRPQPHEPG NLDSSEGGLI  360
MKYRPDWSNL TEILVHLGRG ENLSGLSHTN QYRPDWSNLT VPSVVPAIDP VPVETSPDYL  420
LHGMAETGPG PEGMPFQIEN VASVDLAVSD KLAEAQGFTK PPAQVGEGAS SSRSKDSQFK  480
GKDVVIPQEI SPEYFVSFPE YLRKEKGIPE FSSPGIDSIV KQEDLWSMGF NTAAGMSSSS  540
NELLGNLATP DVPELGMLGG LSDLWDISSF QAAGGSGIDF WPADELPFNE PECQAGQQKD  600
DRSRDP
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B4e-1710923426129Heat shock factor protein 1
5d5v_B4e-1710923426129Heat shock factor protein 1
5d5v_D4e-1710923426129Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1320328ARLKQKKEQ
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress response. Activated by DREB2A under heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006481889.10.0heat stress transcription factor A-2d isoform X1
SwissprotQ8GYY11e-101HSFA3_ARATH; Heat stress transcription factor A-3
TrEMBLA0A2H5MZ680.0A0A2H5MZ68_CITUN; Uncharacterized protein
STRINGXP_006481889.10.0(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM109502529
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G03720.17e-95heat shock transcription factor A3
Publications ? help Back to Top
  1. Jung HS, et al.
    Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9
    [PMID:23918368]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Nie S,Yue H,Xing D
    A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance.
    Plant Physiol., 2016.
    [PMID:26099269]
  4. Hu Z, et al.
    Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.
    Plant J., 2015. 84(6): p. 1178-91
    [PMID:26576681]
  5. Song C,Chung WS,Lim CO
    Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
    Mol. Cells, 2016. 39(6): p. 477-83
    [PMID:27109422]
  6. Kim GD,Cho YH,Lee BH,Yoo SD
    STABILIZED1 Modulates Pre-mRNA Splicing for Thermotolerance.
    Plant Physiol., 2017. 173(4): p. 2370-2382
    [PMID:28223317]
  7. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]