PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_26782_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family bHLH
Protein Properties Length: 609aa    MW: 67582.8 Da    PI: 6.2255
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_26782_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH40.55e-13440486455
                     HHHHHHHHHHHHHHHHHHHHHCTSCC.C...TTS-STCHHHHHHHHHHHHHHH CS
             HLH   4 ahnerErrRRdriNsafeeLrellPk.askapskKlsKaeiLekAveYIksLq 55 
                     +h e+Er+RR+++N++f  Lr ++P+ +      K++Ka+ L  A+ YI++Lq
  Neem_26782_f_1 440 NHVEAERQRREKLNQRFYALRAVVPNiS------KMDKASLLGDAIAYINELQ 486
                     799***********************66......******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142152.2E-5646234IPR025610Transcription factor MYC/MYB N-terminal
SuperFamilySSF474593.27E-18435499IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088817.047436485IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000838.36E-15439490No hitNo description
Gene3DG3DSA:4.10.280.102.9E-18440500IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000101.8E-10440486IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.8E-16442491IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 609 aa     Download sequence    Send to blast
MGSNLWNDED KAMVAAVLGT RAFDYLRSSS ISNENLLMAV GSDENLQNKL SDLVDRPNAS  60
NFSWNYAIFW QISRSKSGDW VLGWGDGSCR EPKEGEESEA TRILSIRLED ETEQKMRKRV  120
LQKLHTLFGG SDEDNYALGL DRVTDTEMFF LASMYFSFPR GEGGPGKCFA SGKHVWLLDT  180
LQVGSDYCVR SFLAKSAGIQ TIVLITTDVG VVELGSVRSV PESLELVQSI RAMFSSNPSV  240
TRVKPMTAVL PIVSEKKDEN ALFSNLGILD RVEAVPKIFG QDLNNSGRIQ PHFSREKLAV  300
RKTEDRPSWE AYANGSRTPF PSVRNGVHGF SWGNVQAVKQ GSPTEIFGSQ TTSNNLQDLV  360
NGVREDFRVN HYQSQKPVQM QIDFSGATSR PTVIARPLSA DSEHSDVEAS CRDERPSVAD  420
ERRPRKRGRK PANGREEPLN HVEAERQRRE KLNQRFYALR AVVPNISKMD KASLLGDAIA  480
YINELQAKLK VMEAEREKFS STSRDSSALE TIPNAESQNP SPDVDIQAAH DEVVVRVSCP  540
LDSHPASRVI QAFKESQITV VESKLSAVND TVFHTFVIKS QGSEQLTKEK LIAAFSCESN  600
SLQPLSSVG
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A1e-29434496264Transcription factor MYC2
5gnj_B1e-29434496264Transcription factor MYC2
5gnj_E1e-29434496264Transcription factor MYC2
5gnj_F1e-29434496264Transcription factor MYC2
5gnj_G1e-29434496264Transcription factor MYC2
5gnj_I1e-29434496264Transcription factor MYC2
5gnj_M1e-29434496264Transcription factor MYC2
5gnj_N1e-29434496264Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1421429RRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that negatively regulates jasmonate (JA) signaling (PubMed:30610166). Negatively regulates JA-dependent response to wounding, JA-induced expression of defense genes, JA-dependent responses against herbivorous insects, and JA-dependent resistance against Botrytis cinerea infection (PubMed:30610166). Plays a positive role in resistance against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PubMed:30610166). {ECO:0000269|PubMed:30610166}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00100PBMTransfer from AT1G01260Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by wounding, feeding with herbivorous insects, infection with the fungal pathogen Botrytis cinerea and infection with the bacterial pathogen Pseudomonas syringae pv tomato DC3000. {ECO:0000269|PubMed:30610166}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006444826.10.0transcription factor bHLH13
SwissprotA0A3Q7ELQ20.0MTB1_SOLLC; Transcription factor MTB1
TrEMBLA0A2H5P0350.0A0A2H5P035_CITUN; Uncharacterized protein
TrEMBLV4U7A90.0V4U7A9_9ROSI; Uncharacterized protein
STRINGXP_006444826.10.0(Citrus clementina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM37582759
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G01260.30.0bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  3. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]