PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Araha.2866s0016.1.p
Organism
Arabidopsis halleri
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 356aa    MW: 40082.1 Da    PI: 9.1468
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Araha.2866s0016.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.71.7e-222186171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rkeksL++l ++fl+l+++ + + + l+++a +L    v  +rRRiYD++N+Le++++++++ kn+++wkg
  Araha.2866s0016.1.p 21 RKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGQL---GV--ERRRIYDVVNILESIGIVARRGKNQYSWKG 86
                         79*****************999************...**..****************************98 PP
2E2F_TDP84.58.3e-27145225171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          +keksL+ll+q+f+k++ +s+++ +tl+++ak+L+s+     ++++k+RR+YDi+NV+ ++nliek     ++k+++rw g
  Araha.2866s0016.1.p 145 KKEKSLWLLSQNFVKMFLCSDDDLITLDSAAKALLSDsqdsvHMRTKVRRLYDIANVFASMNLIEKthipvTRKPAYRWLG 225
                          69*****************************************************************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.0E-231987IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.21E-152084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.3E-262186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-182286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.2E-22141227IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.9E-31145225IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.3E-20146225IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.31E-13147226IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 356 aa     Download sequence    Send to blast
MSSAIVVSQD AESLGLQIYS RKEKSLGVLV SNFLRLYNRD DVDLIGLDDA AGQLGVERRR  60
IYDVVNILES IGIVARRGKN QYSWKGFGEI PRSLNELKEH GMRERLGDSS TNNSDKVSND  120
GEREEPLSLT PDDQENSSSS KMDQKKEKSL WLLSQNFVKM FLCSDDDLIT LDSAAKALLS  180
DSQDSVHMRT KVRRLYDIAN VFASMNLIEK THIPVTRKPA YRWLGSKSIA EKGSSLFNSD  240
EPKKRVFGTE ITNLRAKRNK TDCSSIRKQI GYKKHDQENT EQESKPAASK YVFGPFSPTG  300
ASKTNNNNVG KGRLLEIEAL ASTYQPQYCN HEITGLLGHF TEAWKKWYAE VDRNK*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A8e-34202133224Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAraha.2866s0016.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0745320.0AB074532.1 Arabidopsis thaliana mRNA for E2F-like repressor E2L2, complete cds.
GenBankAY0930240.0AY093024.1 Arabidopsis thaliana unknown protein (At3g01330) mRNA, complete cds.
GenBankBT0004120.0BT000412.1 Arabidopsis thaliana unknown protein (At3g01330) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_020885968.10.0E2F transcription factor-like E2FF
SwissprotQ8RWL00.0E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A178V7U80.0A0A178V7U8_ARATH; E2L2
STRINGAT3G01330.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.10.0DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]