PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Araha.2471s0010.1.p
Organism
Arabidopsis halleri
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family E2F/DP
Protein Properties Length: 357aa    MW: 40518.4 Da    PI: 9.2729
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Araha.2471s0010.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP67.51.6e-211176171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL++l  +fl l+++ + + + l+++a +L    v  +rRRiYD++N+Le+++l++++ kn+++wkg
  Araha.2471s0010.1.p 11 RKDKSLGVLVANFLVLYNRPDVDLIGLDDAAAKL---GV--ERRRIYDVVNILESIGLVARSGKNQYSWKG 76
                         79****************9888************...**..****************************98 PP
2E2F_TDP75.74.8e-24136215171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          +ke++L+ll+q+f+kl+ +s+++ +t+++++k+L+ e    ++++k+RR+YDi+NV+++++liek     ++k+++rw g
  Araha.2471s0010.1.p 136 KKERTLWLLAQNFVKLFLCSDDDLITFDSATKALLIEsqdmNMRTKVRRLYDIANVFSSMKLIEKthvpeTKKPAYRWLG 215
                          6899*******************************99********************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-22977IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.6E-151074IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013729.1E-251176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023198.1E-181276IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.3E-19134217IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.2E-27136215IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.7E-17137215IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.3E-11139216IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 357 aa     Download sequence    Send to blast
MDSPAPQVYS RKDKSLGVLV ANFLVLYNRP DVDLIGLDDA AAKLGVERRR IYDVVNILES  60
IGLVARSGKN QYSWKGFGAV PRALCELKEE GMREKFGIVP YVTKSEMVIF EKEREEAFML  120
TPDDQEFSPS PKLDNKKERT LWLLAQNFVK LFLCSDDDLI TFDSATKALL IESQDMNMRT  180
KVRRLYDIAN VFSSMKLIEK THVPETKKPA YRWLGSKTIF ENRFLTGSAS SLCDRNVPKK  240
RAFGTELTNV NAKRNKPGCS EDSKRYGKQN TNIVIKQEQC DVKPDVKNFA SGPSTPAGTC  300
EMNNVGNNIR PRGRLGDIEA LSTLYQPQYC NPALIRLFEH YHQTFRSCQE EFGRKK*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-33102073228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00511DAPTransfer from AT5G14960Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapAraha.2471s0010.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0745310.0AB074531.1 Arabidopsis thaliana mRNA for E2F-like repressor E2L1, complete cds.
GenBankAJ4178350.0AJ417835.1 Arabidopsis thaliana mRNA for transcription factor E2Fd (e2Fd gene).
GenBankBT0155400.0BT015540.1 Arabidopsis thaliana At5g14906 mRNA sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002871639.10.0E2F transcription factor-like E2FD isoform X2
SwissprotQ9LFQ90.0E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLD7M6P70.0D7M6P7_ARALL; Predicted protein
STRINGAl_scaffold_0006_13970.0(Arabidopsis lyrata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G14960.10.0DP-E2F-like 2