PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK25734.1
Organism
Arabis alpina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family E2F/DP
Protein Properties Length: 381aa    MW: 43369.4 Da    PI: 5.9471
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK25734.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.22.4e-221075171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rkeksL+ll  +f++++++ + + + l+ +a++L    v  +rRRiYD++N+Le++++++++ kn+++w+g
  KFK25734.1 10 RKEKSLGLLVINFVNMCNRDDVDLIGLDYAASRL---GV--ERRRIYDVVNILESIGIVARSGKNQYSWRG 75
                79*****************999************...**..****************************98 PP
2E2F_TDP71.78.1e-23170250171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 +kek L++l+q+f+kl+ +s ++ +tl+ ++++Lv+e     ++++ +RR+YDi+NV +++nliek     ++k+++rw g
  KFK25734.1 170 KKEKCLWVLAQNFVKLFLCSGDELITLDGATHALVNEsqdlmNMRTTVRRLYDIANVYSSMNLIEKtqipgTKKPAYRWLG 250
                 699****************************************************************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.2E-23676IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.31E-16973IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-251075IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.6E-171175IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.8E-19167252IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.4E-23170250IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023199.3E-16171250IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.94E-10173251IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 381 aa     Download sequence    Send to blast
MESGQQSYSR KEKSLGLLVI NFVNMCNRDD VDLIGLDYAA SRLGVERRRI YDVVNILESI  60
GIVARSGKNQ YSWRGFGDVP RVLDELREEG MREKAAMIPY VANLEVEEER AAIVPYVTNS  120
EMEQGMPEKS AIIPYVASSE MVLYDQVKEE PLMLTPDYQE NIPSPKPDGK KEKCLWVLAQ  180
NFVKLFLCSG DELITLDGAT HALVNESQDL MNMRTTVRRL YDIANVYSSM NLIEKTQIPG  240
TKKPAYRWLG YETMSRTKFL DVPASLCDRN EPKKRAFGTE ITNVSAKRNK TDGSEDRKPY  300
GNQNTSIKID QEQCDLKPDL KSLVSGPVTL AETPSKIKGR FGEIEELAST FRPQYCNPGL  360
LGLFGHFRDT YKTWHEEYRK K
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A9e-2992383224Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00511DAPTransfer from AT5G14960Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK25734.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400017.11e-165E2F transcription factor-like E2FD
SwissprotQ9LFQ91e-153E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLA0A087G7820.0A0A087G782_ARAAL; Uncharacterized protein
STRINGA0A087G7820.0(Arabis alpina)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G14960.11e-156DP-E2F-like 2