PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID KFK25733.1
Organism
Arabis alpina
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Arabideae; Arabis
Family E2F/DP
Protein Properties Length: 336aa    MW: 37676.1 Da    PI: 10.0459
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
KFK25733.1genomeMPIPBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP63.23.8e-201176171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rkek L+llt+ flkl+++ + +   ++++a+ L    v  +rRRiYD++N+Le +++++++ kn+++w+g
  KFK25733.1 11 RKEKALGLLTSDFLKLYNQPDVDLFWIDDAAEIL---GV--ERRRIYDVVNILECIGIVARSGKNQYSWRG 76
                79****************9888************...**..****************************98 PP
2E2F_TDP64.41.5e-20133222171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse..............dvknkrRRiYDilNVLealnliek.......kekneirwkg 71 
                 rk+ks ++l+qkflkl+ +s+++ ++++++a++L++e                  k+RR+YD++NV++a+nli+k       k+k++ +w g
  KFK25733.1 133 RKDKSVGVLAQKFLKLFLCSNDDLIKFDDAANALLNEpqdpmnmkptveltP--AKVRRLYDVVNVFSAMNLIDKlymqttpKSKPDLKWLG 222
                 79*******************************************9998532..589*********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.0E-21677IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467856.91E-141074IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-201176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.4E-171276IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.108.0E-18129224IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-21133222IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.0E-13134222IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467858.5E-11135223IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 336 aa     Download sequence    Send to blast
MDFIAQQSYS RKEKALGLLT SDFLKLYNQP DVDLFWIDDA AEILGVERRR IYDVVNILEC  60
IGIVARSGKN QYSWRGFREV PRVLDELREE GMREKAAMIP YVGKLEVEAG MREKAAALSL  120
VQENSPSPKS GGRKDKSVGV LAQKFLKLFL CSNDDLIKFD DAANALLNEP QDPMNMKPTV  180
ELTPAKVRRL YDVVNVFSAM NLIDKLYMQT TPKSKPDLKW LGYEAMSGNK SLAAPASLSG  240
RNEPEKRASG TEFTNVNTKR NKRDRSENRK PYGNQNTSTK VQQRQQVVKP NVTSFVTGPN  300
GRLVKLEPPA DHNIALLGTS KSKANGKLWD EGHGKK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A9e-29102163232Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapKFK25733.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_006400017.11e-113E2F transcription factor-like E2FD
SwissprotQ9LFQ91e-103E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLA0A087G7810.0A0A087G781_ARAAL; Uncharacterized protein
STRINGA0A087G7810.0(Arabis alpina)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G14960.11e-106DP-E2F-like 2