PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_011071778.1
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Pedaliaceae; Sesamum
Family E2F/DP
Protein Properties Length: 376aa    MW: 41842.3 Da    PI: 8.8437
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_011071778.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.21.3e-231883171
         E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                    rk+ksL+ll+++fl+l+++   +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  XP_011071778.1 18 RKQKSLGLLCSNFLSLYNRDGIETIGLDDAASRL---GV--ERRRIYDIVNVLESVGILARKAKNRYTWKG 83
                    79*****************999************...**..****************************98 PP

2E2F_TDP75.84.2e-24153234171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse......dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     rkeksL+lltq+f+kl+ +++ ++++l+++ak L+ +       +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  XP_011071778.1 153 RKEKSLGLLTQNFVKLFLCTDMDMISLDDAAKLLLGDgkhtsmTTRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 234
                     79*****************************************999**********************99999*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.7E-261684IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.17E-161881IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-281883IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.3E-201983IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.2E-23149236IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-31153234IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-18154234IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.54E-12155235IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 376 aa     Download sequence    Send to blast
MAYAAGVESG SKEIPYCRKQ KSLGLLCSNF LSLYNRDGIE TIGLDDAASR LGVERRRIYD  60
IVNVLESVGI LARKAKNRYT WKGFGAIPTA LEDLKKEGLR ETGPAADTSC SEKVSDDDED  120
EMCSDMNSLS QNDKSDSTSA PKSAVPSKSG ENRKEKSLGL LTQNFVKLFL CTDMDMISLD  180
DAAKLLLGDG KHTSMTTRTK VRRLYDIANV LSSMKFIEKT HHPETRKPAF RWLGLNGKSD  240
NVPADSLVLS ESKKRMFGTD LTNTSGKRFK VGEDATQVLK PHNSMRVKHE TENEVERTRS  300
AVKSYQFGPF APANVAKVGA SQDERGKQVV DWESLASAYR PQYHNQALKD LFSHYVEAWK  360
SWYSEVAGKS PIQLMS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-37182264228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapXP_011071778.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011071778.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-125E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2G9GKB50.0A0A2G9GKB5_9LAMI; Transcription factor E2F/dimerization partner (TDP)-like protein
STRINGMigut.I00063.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-119DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]