PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr1g061170.3
Common NameMTR_1g061170
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family HSF
Protein Properties Length: 460aa    MW: 51803.6 Da    PI: 4.6888
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr1g061170.3genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind113.21.8e-35501422103
                      HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXX CS
     HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkelle 95 
                      Fl+k++++++d++l+ +isws+ng sfvv+d+ efa+ +Lp++Fkh+nf+SFvRQLn+YgF+k+++++         weF ++ F+kgkk+ll+
  Medtr1g061170.3  50 FLSKTFDLVDDPSLNPIISWSSNGGSFVVWDPLEFARIILPRHFKHNNFSSFVRQLNTYGFRKIDTDK---------WEFFNEGFQKGKKHLLK 134
                      9****************************************************************999.........***************** PP

                      XXXXXXXX CS
     HSF_DNA-bind  96 kikrkkse 103
                      +i+r++++
  Medtr1g061170.3 135 SIQRRRTS 142
                      *****986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF467856.8E-3546139IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004154.3E-5546139IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene3DG3DSA:1.10.10.104.8E-3647139IPR011991Winged helix-turn-helix DNA-binding domain
PRINTSPR000568.6E-195073IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004474.7E-3150139IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000568.6E-1988100IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS00434089113IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000568.6E-19101113IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009408Biological Processresponse to heat
GO:0010200Biological Processresponse to chitin
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 460 aa     Download sequence    Send to blast
MNPNDEKNSP KFSSSSLMEY EASAIGGGGS GSSDVPVPME CLQMSPVPPF LSKTFDLVDD  60
PSLNPIISWS SNGGSFVVWD PLEFARIILP RHFKHNNFSS FVRQLNTYGF RKIDTDKWEF  120
FNEGFQKGKK HLLKSIQRRR TSQSQQVCNY VGSSSDAGKS GVEVEIERLR KERTVLMQEV  180
VDLQQQQRMT ASHAGNVNQR LQSAEQRQKQ MVSFLAKLFS NPEFLARLKQ KKEQKDIESP  240
RVRRKFIKQN QNEEENLKDG KIVRYQPNWG NMNMSCETQE LSPVSIENSP HYLSHDLAKE  300
MSTGEEDFTS QIENISSDEY AGMHGIFMSN SETNIIEEGS SSFGLDEPLF KGKNVISPNE  360
EVIPENFEGF QSIGTESIIK QEDIWDPSFN VDAGATSNCG NEMWDPMNYG ISDFGVVTSG  420
DMSDMWDIGF GSLGIDRWPA DECPFDKIDS QGGKHDRPT*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B4e-243114110131Heat shock factor protein 1
5d5v_B4e-243114110131Heat shock factor protein 1
5d5v_D4e-243114110131Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1225233ARLKQKKEQ
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mtr.251370.0root
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress response. Activated by DREB2A under heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr1g061170.3
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By heat stress. {ECO:0000269|PubMed:17999647, ECO:0000269|PubMed:18261981}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013468064.10.0heat stress transcription factor A-3 isoform X2
SwissprotQ8GYY16e-99HSFA3_ARATH; Heat stress transcription factor A-3
TrEMBLA0A072VKE10.0A0A072VKE1_MEDTR; Heat shock transcription factor A3
STRINGXP_004497602.10.0(Cicer arietinum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF87823038
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G03720.11e-93heat shock transcription factor A3
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Jung HS, et al.
    Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light.
    Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9
    [PMID:23918368]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Nie S,Yue H,Xing D
    A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance.
    Plant Physiol., 2016.
    [PMID:26099269]
  5. Hu Z, et al.
    Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis.
    Plant J., 2015. 84(6): p. 1178-91
    [PMID:26576681]
  6. Song C,Chung WS,Lim CO
    Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
    Mol. Cells, 2016. 39(6): p. 477-83
    [PMID:27109422]
  7. Kim GD,Cho YH,Lee BH,Yoo SD
    STABILIZED1 Modulates Pre-mRNA Splicing for Thermotolerance.
    Plant Physiol., 2017. 173(4): p. 2370-2382
    [PMID:28223317]
  8. Song C,Lee J,Kim T,Hong JC,Lim CO
    VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
    Planta, 2018. 247(6): p. 1439-1448
    [PMID:29536220]