PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Han007310
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Heliantheae alliance; Heliantheae; Helianthus
Family EIL
Protein Properties Length: 206aa    MW: 23608.7 Da    PI: 5.2118
Description EIL family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PUT-169a-Helianthus_annuus-51583PU_refplantGDBView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
       EIN3   1 eelkkrmwkdqmllkrlkerkkqlledkeaatgakksnksneqarrkkmsraQDgiLkYMlkemevcnaqGfvYgiipekgkpvegasdsLraWWkekve 100
                +el++rmw+d+m+l+rlke+ k     ke + ++ k ++s+eqarrkkmsraQDgiLkYMlk+mevc+aqGfvYgiipekgkpv+gasd+Lr+WWkekv+
                79*************99999886....89999******************************************************************** PP

       EIN3 101 fdrngpaaiskyqaknlilsgesslqtersseshslselqDTtlgSLLsalmqhcdppqrrfplekg 167
                fdrngpaaisky a++ ++++++sl   + s++h+l+elqDTtlgSLLsalmqhcdppqrrfplekg
                ********************99999..69************************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF048736.1E-8346206No hitNo description
Gene3DG3DSA:1.10.3180.102.4E-16169206IPR023278Ethylene insensitive 3-like protein, DNA-binding domain
SuperFamilySSF1167684.05E-13172206IPR023278Ethylene insensitive 3-like protein, DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 206 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4zds_A8e-19170206137Protein ETHYLENE INSENSITIVE 3
4zds_B8e-19170206137Protein ETHYLENE INSENSITIVE 3
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor acting as a positive regulator in the ethylene response pathway. Is required for ethylene responsiveness in adult plant tissues. Binds a primary ethylene response element present in the ETHYLENE-RESPONSE-FACTOR1 promoter with consequence to activate the transcription of this gene. {ECO:0000269|PubMed:9215635, ECO:0000269|PubMed:9851977}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021982638.11e-148protein ETHYLENE INSENSITIVE 3-like
SwissprotO246061e-101EIN3_ARATH; Protein ETHYLENE INSENSITIVE 3
TrEMBLA0A251TXF11e-147A0A251TXF1_HELAN; Putative ethylene insensitive 3-like protein, DNA-binding domain-containing protein
STRINGVIT_13s0047g00250.t011e-107(Vitis vinifera)
STRINGXP_008379003.11e-108(Malus domestica)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G20770.13e-82EIL family protein
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
  2. Kim HG, et al.
    GDSL LIPASE1 modulates plant immunity through feedback regulation of ethylene signaling.
    Plant Physiol., 2013. 163(4): p. 1776-91
  3. Zhong S, et al.
    Ethylene-orchestrated circuitry coordinates a seedling's response to soil cover and etiolated growth.
    Proc. Natl. Acad. Sci. U.S.A., 2014. 111(11): p. 3913-20
  4. Kim HG, et al.
    GDSL lipase 1 regulates ethylene signaling and ethylene-associated systemic immunity in Arabidopsis.
    FEBS Lett., 2014. 588(9): p. 1652-8
  5. Jourda C, et al.
    Expansion of banana (Musa acuminata) gene families involved in ethylene biosynthesis and signalling after lineage-specific whole-genome duplications.
    New Phytol., 2014. 202(3): p. 986-1000
  6. Zhang GB,Yi HY,Gong JM
    The Arabidopsis ethylene/jasmonic acid-NRT signaling module coordinates nitrate reallocation and the trade-off between growth and environmental adaptation.
    Plant Cell, 2014. 26(10): p. 3984-98
  7. Wang J, et al.
    Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation-induced anthocyanin accumulation.
    J Integr Plant Biol, 2015. 57(8): p. 708-21
  8. Ge XM, et al.
    Heterotrimeric G protein mediates ethylene-induced stomatal closure via hydrogen peroxide synthesis in Arabidopsis.
    Plant J., 2015. 82(1): p. 138-50
  9. Kazan K
    Diverse roles of jasmonates and ethylene in abiotic stress tolerance.
    Trends Plant Sci., 2015. 20(4): p. 219-29
  10. Yang C, et al.
    MAOHUZI6/ETHYLENE INSENSITIVE3-LIKE1 and ETHYLENE INSENSITIVE3-LIKE2 Regulate Ethylene Response of Roots and Coleoptiles and Negatively Affect Salt Tolerance in Rice.
    Plant Physiol., 2015. 169(1): p. 148-65
  11. Contreras-Cornejo HA, et al.
    Mitogen-Activated Protein Kinase 6 and Ethylene and Auxin Signaling Pathways Are Involved in Arabidopsis Root-System Architecture Alterations by Trichoderma atroviride.
    Mol. Plant Microbe Interact., 2015. 28(6): p. 701-10
  12. Li J,Xu HH,Liu WC,Zhang XW,Lu YT
    Ethylene Inhibits Root Elongation during Alkaline Stress through AUXIN1 and Associated Changes in Auxin Accumulation.
    Plant Physiol., 2015. 168(4): p. 1777-91
  13. Street IH, et al.
    Ethylene Inhibits Cell Proliferation of the Arabidopsis Root Meristem.
    Plant Physiol., 2015. 169(1): p. 338-50
  14. Ju C,Chang C
    Mechanistic Insights in Ethylene Perception and Signal Transduction.
    Plant Physiol., 2015. 169(1): p. 85-95
  15. Qing D, et al.
    Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene Regulates Water Transport via the C-Terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis.
    Mol Plant, 2016. 9(1): p. 158-174
  16. Zhang Y,Liu J,Chai J,Xing D
    Mitogen-activated protein kinase 6 mediates nuclear translocation of ORE3 to promote ORE9 gene expression in methyl jasmonate-induced leaf senescence.
    J. Exp. Bot., 2016. 67(1): p. 83-94
  17. Li X,Pan Y,Chang B,Wang Y,Tang Z
    NO Promotes Seed Germination and Seedling Growth Under High Salt May Depend on EIN3 Protein in Arabidopsis.
    Front Plant Sci, 2015. 6: p. 1203
  18. Yu Y, et al.
    Salt Stress and Ethylene Antagonistically Regulate Nucleocytoplasmic Partitioning of COP1 to Control Seed Germination.
    Plant Physiol., 2016. 170(4): p. 2340-50
  19. Pelagio-Flores R,Ruiz-Herrera LF,López-Bucio J
    Serotonin modulates Arabidopsis root growth via changes in reactive oxygen species and jasmonic acid-ethylene signaling.
    Physiol Plant, 2016. 158(1): p. 92-105
  20. Tao S, et al.
    The THO/TREX Complex Active in miRNA Biogenesis Negatively Regulates Root-Associated Acid Phosphatase Activity Induced by Phosphate Starvation.
    Plant Physiol., 2016. 171(4): p. 2841-53
  21. Song L, et al.
    The Molecular Mechanism of Ethylene-Mediated Root Hair Development Induced by Phosphate Starvation.
    PLoS Genet., 2016. 12(7): p. e1006194
  22. Jeong J, et al.
    Phytochrome and Ethylene Signaling Integration in Arabidopsis Occurs via the Transcriptional Regulation of Genes Co-targeted by PIFs and EIN3.
    Front Plant Sci, 2016. 7: p. 1055
  23. Tsai KJ,Lin CY,Ting CY,Shih MC
    Ethylene-Regulated Glutamate Dehydrogenase Fine-Tunes Metabolism during Anoxia-Reoxygenation.
    Plant Physiol., 2016. 172(3): p. 1548-1562
  24. Zhang F, et al.
    EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling.
    Nat Commun, 2016. 7: p. 13018
  25. Liu G, et al.
    Local Transcriptional Control of YUCCA Regulates Auxin Promoted Root-Growth Inhibition in Response to Aluminium Stress in Arabidopsis.
    PLoS Genet., 2016. 12(10): p. e1006360
  26. Shen X,Li Y,Pan Y,Zhong S
    Activation of HLS1 by Mechanical Stress via Ethylene-Stabilized EIN3 Is Crucial for Seedling Soil Emergence.
    Front Plant Sci, 2016. 7: p. 1571
  27. Shi H, et al.
    The Red Light Receptor Phytochrome B Directly Enhances Substrate-E3 Ligase Interactions to Attenuate Ethylene Responses.
    Dev. Cell, 2016. 39(5): p. 597-610
  28. Wawrzyńska A,Sirko A
    EIN3 interferes with the sulfur deficiency signaling in Arabidopsis thaliana through direct interaction with the SLIM1 transcription factor.
    Plant Sci., 2016. 253: p. 50-57
  29. Zemlyanskaya EV,Levitsky VG,Oshchepkov DY,Grosse I,Mironova VV
    The Interplay of Chromatin Landscape and DNA-Binding Context Suggests Distinct Modes of EIN3 Regulation in Arabidopsis thaliana.
    Front Plant Sci, 2016. 7: p. 2044
  30. He X,Jiang J,Wang CQ,Dehesh K
    ORA59 and EIN3 interaction couples jasmonate-ethylene synergistic action to antagonistic salicylic acid regulation of PDF expression.
    J Integr Plant Biol, 2017. 59(4): p. 275-287
  31. Abozeid A, et al.
    Ethylene Improves Root System Development under Cadmium Stress by Modulating Superoxide Anion Concentration in Arabidopsis thaliana.
    Front Plant Sci, 2017. 8: p. 253
  32. Quan R, et al.
    EIN3 and SOS2 synergistically modulate plant salt tolerance.
    Sci Rep, 2017. 7: p. 44637
  33. Kim GD,Cho YH,Yoo SD
    Regulatory Functions of Cellular Energy Sensor SNF1-Related Kinase1 for Leaf Senescence Delay through ETHYLENE- INSENSITIVE3 Repression.
    Sci Rep, 2017. 7(1): p. 3193
  34. Liu Y, et al.
    Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1.
    Plant Cell, 2017. 29(9): p. 2269-2284
  35. Liu X,Li Y,Zhong S
    Interplay between Light and Plant Hormones in the Control of Arabidopsis Seedling Chlorophyll Biosynthesis.
    Front Plant Sci, 2017. 8: p. 1433
  36. Zhang F, et al.
    EIN2 mediates direct regulation of histone acetylation in the ethylene response.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(38): p. 10274-10279
  37. Yan Z, et al.
    Type B Response Regulators Act As Central Integrators in Transcriptional Control of the Auxin Biosynthesis Enzyme TAA1.
    Plant Physiol., 2017. 175(3): p. 1438-1454
  38. Liu X, et al.
    EIN3 and PIF3 Form an Interdependent Module That Represses Chloroplast Development in Buried Seedlings.
    Plant Cell, 2017. 29(12): p. 3051-3067
  39. Feng Y, et al.
    Ethylene promotes root hair growth through coordinated EIN3/EIL1 and RHD6/RSL1 activity in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2017. 114(52): p. 13834-13839
  40. Harkey AF, et al.
    Identification of Transcriptional and Receptor Networks That Control Root Responses to Ethylene.
    Plant Physiol., 2018. 176(3): p. 2095-2118
  41. Zhang F,Wang L,Ko EE,Shao K,Qiao H
    Histone Deacetylases SRT1 and SRT2 Interact with ENAP1 to Mediate Ethylene-Induced Transcriptional Repression.
    Plant Cell, 2018. 30(1): p. 153-166
  42. Lv B, et al.
    Brassinosteroids regulate root growth by controlling reactive oxygen species homeostasis and dual effect on ethylene synthesis in Arabidopsis.
    PLoS Genet., 2018. 14(1): p. e1007144
  43. Dou L,He K,Higaki T,Wang X,Mao T
    Ethylene Signaling Modulates Cortical Microtubule Reassembly in Response to Salt Stress.
    Plant Physiol., 2018. 176(3): p. 2071-2081
  44. Meng LS,Xu MK,Wan W,Wang JY
    Integration of Environmental and Developmental (or Metabolic) Control of Seed Mass by Sugar and Ethylene Metabolisms in Arabidopsis.
    J. Agric. Food Chem., 2018. 66(13): p. 3477-3488
  45. Munné-Bosch S,Simancas B,Müller M
    Ethylene signaling cross-talk with other hormones in Arabidopsis thaliana exposed to contrasting phosphate availability: Differential effects in roots, leaves and fruits.
    J. Plant Physiol., 2018. 226: p. 114-122