PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009121540.1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica
Family CO-like
Protein Properties Length: 366aa    MW: 41572.1 Da    PI: 7.3374
Description CO-like family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009121540.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
        zf-B_box  4 rkCpeHeekelqlfCedCqqllCedClleeHkg......Htvv 40
                    r C+++++   + +C+ ++ +lC++C  + H+       H++v
                    78******99*********************667788888876 PP

        zf-B_box   2 eerkCpeHeekelqlfCedCqqllCedClleeHkg......Htvvpl 42 
                     + r+C+ +e+ ++ + Ce +++ lC  C le H+       H++vp+
                     5689*****************************66899999*99986 PP

             CCT   1 ReaallRYkeKrktRkFeKkirYesRKavAesRpRvKGrFvkqa 44 
                     Rea++lRY+eK+k+RkFeK+irY+sRKa+Ae+RpR++GrF+k +
                     9****************************************986 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM003362.6E-91663IPR000315B-box-type zinc finger
PROSITE profilePS5011910.1251663IPR000315B-box-type zinc finger
CDDcd000211.06E-61963No hitNo description
PROSITE profilePS5011911.81859106IPR000315B-box-type zinc finger
PfamPF006432.0E-861106IPR000315B-box-type zinc finger
CDDcd000216.82E-962106No hitNo description
SMARTSM003361.2E-1164106IPR000315B-box-type zinc finger
PfamPF062032.4E-16293334IPR010402CCT domain
PROSITE profilePS5101716.073293335IPR010402CCT domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0007623Biological Processcircadian rhythm
GO:0009909Biological Processregulation of flower development
GO:0010018Biological Processfar-red light signaling pathway
GO:0005634Cellular Componentnucleus
GO:0005515Molecular Functionprotein binding
GO:0008270Molecular Functionzinc ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 366 aa     Download sequence    Send to blast
Nucleic Localization Signal ? help Back to Top
No. Start End Sequence
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves, shoots and shoot apical meristem. Detected in the vascular tissue of the hypocotyl, the cotyledons and the leaves. Restricted to the protoxylem and phloem in young inflorescence stems and to the phloem only in older inflorescences. Also detected in the vascular tissue of the root. {ECO:0000269|PubMed:15229176}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that acts in the long day flowering pathway and may mediate between the circadian clock and the control of flowering. Plays a role in the regulation of flowering time by acting on 'SUPPRESSOR OF OVEREXPRESSION OF CO1', 'TERMINAL FLOWER 1' and 'FLOWERING LOCUS T'. Also regulates P5CS2 and ACS10 (involved in proline and ethylene biosynthesis, respectively). Regulates the expression of NAKR1 by binding to the 5'-TGTG(N2-3)ATG-3' motif (PubMed:27255839). {ECO:0000269|PubMed:10834834, ECO:0000269|PubMed:11323677, ECO:0000269|PubMed:21950734, ECO:0000269|PubMed:27255839}.
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Expressed with a circadian rhythm showing a broad peak between 12 hours and dawn. Higher expression under long days.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY2808680.0AY280868.2 Brassica napus putative beta-glucan elicitor receptor (Bger1), constans-like protein (CoL), and constans (Coa1) genes, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009121540.10.0PREDICTED: zinc finger protein CONSTANS
SwissprotQ390570.0CONS_ARATH; Zinc finger protein CONSTANS
TrEMBLM4CWS20.0M4CWS2_BRARP; Uncharacterized protein
TrEMBLO488830.0O48883_BRANA; Constans
STRINGBra008669.1-P0.0(Brassica rapa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G15840.11e-152B-box type zinc finger protein with CCT domain
Publications ? help Back to Top
  1. Yeoh CC, et al.
    Fine mapping links the FTa1 flowering time regulator to the dominant spring1 locus in Medicago.
    PLoS ONE, 2013. 8(1): p. e53467
  2. Joon Seo P,Jung JH,Park MJ,Lee K,Park CM
    Controlled turnover of CONSTANS protein by the HOS1 E3 ligase regulates floral transition at low temperatures.
    Plant Signal Behav, 2013. 8(4): p. e23780
  3. Yu Y, et al.
    MlWRKY12, a novel Miscanthus transcription factor, participates in pith secondary cell wall formation and promotes flowering.
    Plant Sci., 2013. 212: p. 1-9
  4. Sgamma T,Jackson A,Muleo R,Thomas B,Massiah A
    TEMPRANILLO is a regulator of juvenility in plants.
    Sci Rep, 2014. 4: p. 3704
  5. Qian H, et al.
    The circadian clock gene regulatory module enantioselectively mediates imazethapyr-induced early flowering in Arabidopsis thaliana.
    J. Plant Physiol., 2014. 171(5): p. 92-8
  6. Ortiz-Marchena MI, et al.
    Photoperiodic control of carbon distribution during the floral transition in Arabidopsis.
    Plant Cell, 2014. 26(2): p. 565-84
  7. Endo M,Kudo D,Koto T,Shimizu H,Araki T
    Light-dependent destabilization of PHL in Arabidopsis.
    Plant Signal Behav, 2014. 9(3): p. e28118
  8. Steinbach Y,Hennig L
    Arabidopsis MSI1 functions in photoperiodic flowering time control.
    Front Plant Sci, 2014. 5: p. 77
  9. Johansson M,Staiger D
    SRR1 is essential to repress flowering in non-inductive conditions in Arabidopsis thaliana.
    J. Exp. Bot., 2014. 65(20): p. 5811-22
  10. Shim JS,Imaizumi T
    Circadian clock and photoperiodic response in Arabidopsis: from seasonal flowering to redox homeostasis.
    Biochemistry, 2015. 54(2): p. 157-70
  11. Fu J,Yang L,Dai S
    Identification and characterization of the CONSTANS-like gene family in the short-day plant Chrysanthemum lavandulifolium.
    Mol. Genet. Genomics, 2015. 290(3): p. 1039-54
  12. Song YH,Shim JS,Kinmonth-Schultz HA,Imaizumi T
    Photoperiodic flowering: time measurement mechanisms in leaves.
    Annu Rev Plant Biol, 2015. 66: p. 441-64
  13. Liu T,Zhu S,Tang Q,Tang S
    Identification of a CONSTANS homologous gene with distinct diurnal expression patterns in varied photoperiods in ramie (Boehmeria nivea L. Gaud).
    Gene, 2015. 560(1): p. 63-70
  14. Golembeski GS,Kinmonth-Schultz HA,Song YH,Imaizumi T
    Photoperiodic flowering regulation in Arabidopsis thaliana.
    Adv. Bot. Res., 2014. 72: p. 1-28
  15. Leal Valentim F, et al.
    A quantitative and dynamic model of the Arabidopsis flowering time gene regulatory network.
    PLoS ONE, 2015. 10(2): p. e0116973
  16. Han Y,Zhang X,Wang W,Wang Y,Ming F
    Correction: the suppression of WRKY44 by GIGANTEA-miR172 pathway is involved in drought response of Arabidopsis thaliana.
    PLoS ONE, 2015. 10(4): p. e0124854
  17. Lucas-Reina E,Romero-Campero FJ,Romero JM,Valverde F
    An Evolutionarily Conserved DOF-CONSTANS Module Controls Plant Photoperiodic Signaling.
    Plant Physiol., 2015. 168(2): p. 561-74
  18. Simon S,Rühl M,de Montaigu A,Wötzel S,Coupland G
    Evolution of CONSTANS Regulation and Function after Gene Duplication Produced a Photoperiodic Flowering Switch in the Brassicaceae.
    Mol. Biol. Evol., 2015. 32(9): p. 2284-301
  19. Ortiz-Marchena MI,Romero JM,Valverde F
    Photoperiodic control of sugar release during the floral transition: What is the role of sugars in the florigenic signal?
    Plant Signal Behav, 2015. 10(5): p. e1017168
  20. Wang C,Dehesh K
    From retrograde signaling to flowering time.
    Plant Signal Behav, 2015. 10(6): p. e1022012
  21. Hajdu A, et al.
    High-level expression and phosphorylation of phytochrome B modulates flowering time in Arabidopsis.
    Plant J., 2015. 83(5): p. 794-805
  22. Golembeski GS,Imaizumi T
    Photoperiodic Regulation of Florigen Function in Arabidopsis thaliana.
    Arabidopsis Book, 2015. 13: p. e0178
  23. Jang K,Lee HG,Jung SJ,Paek NC,Seo PJ
    The E3 Ubiquitin Ligase COP1 Regulates Thermosensory Flowering by Triggering GI Degradation in Arabidopsis.
    Sci Rep, 2015. 5: p. 12071
  24. Marín-González E, et al.
    SHORT VEGETATIVE PHASE Up-Regulates TEMPRANILLO2 Floral Repressor at Low Ambient Temperatures.
    Plant Physiol., 2015. 169(2): p. 1214-24
  25. Sarid-Krebs L, et al.
    Phosphorylation of CONSTANS and its COP1-dependent degradation during photoperiodic flowering of Arabidopsis.
    Plant J., 2015. 84(3): p. 451-63
  26. Lazaro A,Mouriz A,Piñeiro M,Jarillo JA
    Red Light-Mediated Degradation of CONSTANS by the E3 Ubiquitin Ligase HOS1 Regulates Photoperiodic Flowering in Arabidopsis.
    Plant Cell, 2015. 27(9): p. 2437-54
  27. Matsoukas IG
    Florigens and antiflorigens: a molecular genetic understanding.
    Essays Biochem., 2015. 58: p. 133-49
  28. Mulki MA,von Korff M
    CONSTANS Controls Floral Repression by Up-Regulating VERNALIZATION2 (VRN-H2) in Barley.
    Plant Physiol., 2016. 170(1): p. 325-37
  29. Xu L, et al.
    Genome-wide association study reveals the genetic architecture of flowering time in rapeseed (Brassica napus L.).
    DNA Res., 2016. 23(1): p. 43-52
  30. Wada T,Tominaga-Wada R
    CAPRICE family genes control flowering time through both promoting and repressing CONSTANS and FLOWERING LOCUS T expression.
    Plant Sci., 2015. 241: p. 260-5
  31. Tang Q, et al.
    The mitogen-activated protein kinase phosphatase PHS1 regulates flowering in Arabidopsis thaliana.
    Planta, 2016. 243(4): p. 909-23
  32. Xu F, et al.
    DELLA proteins physically interact with CONSTANS to regulate flowering under long days in Arabidopsis.
    FEBS Lett., 2016. 590(4): p. 541-9
  33. Kinmonth-Schultz HA, et al.
    Cool night-time temperatures induce the expression of CONSTANS and FLOWERING LOCUS T to regulate flowering in Arabidopsis.
    New Phytol., 2016. 211(1): p. 208-24
  34. Sun X, et al.
    The Oryza sativa Regulator HDR1 Associates with the Kinase OsK4 to Control Photoperiodic Flowering.
    PLoS Genet., 2016. 12(3): p. e1005927
  35. Nemoto Y,Nonoue Y,Yano M,Izawa T
    Hd1,a CONSTANS ortholog in rice, functions as an Ehd1 repressor through interaction with monocot-specific CCT-domain protein Ghd7.
    Plant J., 2016. 86(3): p. 221-33
  36. Fernández V,Takahashi Y,Le Gourrierec J,Coupland G
    Photoperiodic and thermosensory pathways interact through CONSTANS to promote flowering at high temperature under short days.
    Plant J., 2016. 86(5): p. 426-40
  37. Zhu Y,Liu L,Shen L,Yu H
    NaKR1 regulates long-distance movement of FLOWERING LOCUS T in Arabidopsis.
    Nat Plants, 2016. 2(6): p. 16075
  38. Wang H, et al.
    The DELLA-CONSTANS Transcription Factor Cascade Integrates Gibberellic Acid and Photoperiod Signaling to Regulate Flowering.
    Plant Physiol., 2016. 172(1): p. 479-88
  39. Gil KE, et al.
    Alternative splicing provides a proactive mechanism for the diurnal CONSTANS dynamics in Arabidopsis photoperiodic flowering.
    Plant J., 2017. 89(1): p. 128-140
  40. Shim JS,Kubota A,Imaizumi T
    Circadian Clock and Photoperiodic Flowering in Arabidopsis: CONSTANS Is a Hub for Signal Integration.
    Plant Physiol., 2017. 173(1): p. 5-15
  41. Park HJ,Kim WY,Pardo JM,Yun DJ
    Molecular Interactions Between Flowering Time and Abiotic Stress Pathways.
    Int Rev Cell Mol Biol, 2016. 327: p. 371-412
  42. Riboni M,Robustelli Test A,Galbiati M,Tonelli C,Conti L
    ABA-dependent control of GIGANTEA signalling enables drought escape via up-regulation of FLOWERING LOCUS T in Arabidopsis thaliana.
    J. Exp. Bot., 2016. 67(22): p. 6309-6322
  43. Song YH
    The Effect of Fluctuations in Photoperiod and Ambient Temperature on the Timing of Flowering: Time to Move on Natural Environmental Conditions.
    Mol. Cells, 2016. 39(10): p. 715-721
  44. Hayama R, et al.
    PSEUDO RESPONSE REGULATORs stabilize CONSTANS protein to promote flowering in response to day length.
    EMBO J., 2017. 36(7): p. 904-918
  45. Gnesutta N, et al.
    CONSTANS Imparts DNA Sequence Specificity to the Histone Fold NF-YB/NF-YC Dimer.
    Plant Cell, 2017. 29(6): p. 1516-1532
  46. Liu J, et al.
    MicroRNA319-regulated TCPs interact with FBHs and PFT1 to activate CO transcription and control flowering time in Arabidopsis.
    PLoS Genet., 2017. 13(5): p. e1006833
  47. Cai D,Liu H,Sang N,Huang X
    Identification and characterization of CONSTANS-like (COL) gene family in upland cotton (Gossypium hirsutum L.).
    PLoS ONE, 2017. 12(6): p. e0179038
  48. Kubota A, et al.
    TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis.
    PLoS Genet., 2017. 13(6): p. e1006856
  49. Shibuta M,Abe M
    FE Controls the Transcription of Downstream Flowering Regulators Through Two Distinct Mechanisms in Leaf Phloem Companion Cells.
    Plant Cell Physiol., 2017. 58(11): p. 2017-2025
  50. Kurokura T,Samad S,Koskela E,Mouhu K,Hytönen T
    Fragaria vesca CONSTANS controls photoperiodic flowering and vegetative development.
    J. Exp. Bot., 2017. 68(17): p. 4839-4850
  51. Hassidim M, et al.
    CIRCADIAN CLOCK ASSOCIATED1 (CCA1) and the Circadian Control of Stomatal Aperture.
    Plant Physiol., 2017. 175(4): p. 1864-1877
  52. Ordoñez-Herrera N, et al.
    The Transcription Factor COL12 Is a Substrate of the COP1/SPA E3 Ligase and Regulates Flowering Time and Plant Architecture.
    Plant Physiol., 2018. 176(2): p. 1327-1340
  53. Kumar S,Choudhary P,Gupta M,Nath U
    VASCULAR PLANT ONE-ZINC FINGER1 (VOZ1) and VOZ2 Interact with CONSTANS and Promote Photoperiodic Flowering Transition.
    Plant Physiol., 2018. 176(4): p. 2917-2930
  54. Kumar A,Singh A,Panigrahy M,Sahoo PK,Panigrahi KCS
    Carbon nanoparticles influence photomorphogenesis and flowering time in Arabidopsis thaliana.
    Plant Cell Rep., 2018. 37(6): p. 901-912
  55. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.