PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT5G08330.1
Common NameAtTCP11, CHE, F8L15.60, TCP11, TCP21
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family TCP
Protein Properties Length: 239aa    MW: 24751.6 Da    PI: 10.2008
Description TCP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT5G08330.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          TCP   2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgtssssaseceaesssssas...nsssg........ 88 
                  a+kk +++++h+kv+gR+RR+R+++ caar+F+L++eLG+++d++tieWLl+qa+p+i+++tgt++++as++ ++s s s+        +        
                  79**************************************************************99999777.2222222222220...133444444 PP

          TCP  89 ........................................................kaaksaakskksqksaasalnlakesrakar 119
                                                                          +             ++ ++l + ++++++a+
  AT5G08330.1 119 esgggggggltvghtmgtslmggggsggfwavparpdfgqvwsfatgappemvfaqQ-------------QQPATLFVRHQQQQQAS 192
                  455667777777777777777777777888888888888777654444433333322.............22223333333333333 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5136928.2093185IPR017887Transcription factor TCP subgroup
PfamPF036341.5E-3231149IPR005333Transcription factor, TCP
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0042752Biological Processregulation of circadian rhythm
GO:0043433Biological Processnegative regulation of sequence-specific DNA binding transcription factor activity
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0005515Molecular Functionprotein binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009006anatomyshoot system
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001054developmental stagevascular leaf senescent stage
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 239 aa     Download sequence    Send to blast
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.229110.0floral meristem| flower| root
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT5G08330-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves, roots, and stems. {ECO:0000269|PubMed:19286557}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in the regulation of the circadian clock. Acts as a repressor of CCA1 by binding to its promoter. No binding to the LHY promoter. {ECO:0000269|PubMed:19286557}.
Function -- GeneRIF ? help Back to Top
  1. identification of CHE (At5g08330), a TCP transcription factor that binds specifically to the CCA1 promoter; expression of CHE is regulated by CCA1, thus adding a CCA1/CHE feedback loop to the Arabidopsis circadian network
    [PMID: 19286557]
  2. Expression of a repressor form of TCP11 in plants demonstrates that TCP11 is a developmental regulator that influences growth of leaves, stems and petioles, and pollen development. Distinct DNA-binding of TCP11 is due to T15 residue in TCP domain. [TCP11]
    [PMID: 21241251]
  3. ZTL interacts directly with CHE and can mediate CHE ubiquitylation.CHE protein is degraded in the dark.
    [PMID: 29794020]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Interaction ? help Back to Top
Source Intact With
BioGRIDAT5G23280, AT5G51910, AT5G60120, AT5G60970, AT1G19000, AT1G24625, AT1G30210, AT1G35560, AT1G53230, AT1G58100, AT1G69690
IntActSearch Q9FTA2
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: No effect on the period length or phase of the circadian clock. {ECO:0000269|PubMed:19286557}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT5G08330
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF4120740.0AF412074.1 Arabidopsis thaliana AT5g08330/F8L15_60 mRNA, complete cds.
GenBankAL3921740.0AL392174.1 Arabidopsis thaliana DNA chromosome 5, BAC clone F8L15 (ESSA project).
GenBankAY0726200.0AY072620.1 Arabidopsis thaliana AT5g08330/F8L15_60 mRNA, complete cds.
GenBankCP0026880.0CP002688.1 Arabidopsis thaliana chromosome 5 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_196450.11e-174TCP family transcription factor
SwissprotQ9FTA21e-175TCP21_ARATH; Transcription factor TCP21
STRINGAT5G08330.11e-173(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP85141016
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  3. Marsch-Martinez N, et al.
    BOLITA, an Arabidopsis AP2/ERF-like transcription factor that affects cell expansion and proliferation/differentiation pathways.
    Plant Mol. Biol., 2006. 62(6): p. 825-43
  4. Aguilar-Martínez JA,Poza-Carrión C,Cubas P
    Arabidopsis BRANCHED1 acts as an integrator of branching signals within axillary buds.
    Plant Cell, 2007. 19(2): p. 458-72
  5. Ascencio-Ib
    Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.
    Plant Physiol., 2008. 148(1): p. 436-54
  6. Pruneda-Paz JL,Breton G,Para A,Kay SA
    A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock.
    Science, 2009. 323(5920): p. 1481-5
  7. Mart
    TCP genes: a family snapshot ten years later.
    Trends Plant Sci., 2010. 15(1): p. 31-9
  8. Viola IL,Uberti Manassero NG,Ripoll R,Gonzalez DH
    The Arabidopsis class I TCP transcription factor AtTCP11 is a developmental regulator with distinct DNA-binding properties due to the presence of a threonine residue at position 15 of the TCP domain.
    Biochem. J., 2011. 435(1): p. 143-55
  9. Arabidopsis Interactome Mapping Consortium
    Evidence for network evolution in an Arabidopsis interactome map.
    Science, 2011. 333(6042): p. 601-7
  10. Danisman S, et al.
    Analysis of functional redundancies within the Arabidopsis TCP transcription factor family.
    J. Exp. Bot., 2013. 64(18): p. 5673-85
  11. Aguilar-Mart
    Analysis of the role of Arabidopsis class I TCP genes AtTCP7, AtTCP8, AtTCP22, and AtTCP23 in leaf development.
    Front Plant Sci, 2013. 4: p. 406
  12. Kim SH, et al.
    The Arabidopsis immune adaptor SRFR1 interacts with TCP transcription factors that redundantly contribute to effector-triggered immunity.
    Plant J., 2014. 78(6): p. 978-89
  13. Chen GH,Sun JY,Liu M,Liu J,Yang WC
    SPOROCYTELESS is a novel embryophyte-specific transcription repressor that interacts with TPL and TCP proteins in Arabidopsis.
    J Genet Genomics, 2014. 41(12): p. 617-25
  14. Wu JF, et al.
    LWD-TCP complex activates the morning gene CCA1 in Arabidopsis.
    Nat Commun, 2016. 7: p. 13181
  15. Ng DW,Chen HH,Chen ZJ
    Heterologous protein-DNA interactions lead to biased allelic expression of circadian clock genes in interspecific hybrids.
    Sci Rep, 2017. 7: p. 45087
  16. Lee CM, et al.
    Decoys Untangle Complicated Redundancy and Reveal Targets of Circadian Clock F-Box Proteins.
    Plant Physiol., 2018. 177(3): p. 1170-1186