PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT4G37750.1

Common Name

ANT, CKC, CKC1, DRG, OVM, T28I19.30

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

AP2

Protein Properties

Length: 555aa MW: 61724.9 Da PI: 7.8658

Description

AP2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT4G37750.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	49.7	9.4e-16	282	341	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrd.pse.ng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 s+y+GV++++++gr++A+++d + g ++ ++++lg ++ +e+Aa+a++ a++k++g AT4G37750.1 282 SQYRGVTRHRWTGRYEAHLWDnSFKkEGhsRKgRQVYLGGYDMEEKAARAYDLAALKYWG 341 78*****************644456687446***********************98 PP
2	AP2	51	3.6e-16	384	435	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 s y+GV+++++ grW A+I + +k +lg+fgt eeAa+a++ a+ k++g AT4G37750.1 384 SIYRGVTRHHQHGRWQARIGRVAG---NKDLYLGTFGTQEEAAEAYDVAAIKFRG 435 57**************988532...5**********************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	2.29E-16	282	350	IPR016177	DNA-binding domain
CDD	cd00018	3.12E-21	282	348	No hit	No description
Pfam	PF00847	6.5E-13	282	341	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	2.2E-15	283	349	IPR001471	AP2/ERF domain
SMART	SM00380	1.5E-26	283	355	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	18.755	283	349	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.2E-6	284	295	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	6.54E-18	384	444	IPR016177	DNA-binding domain
CDD	cd00018	1.01E-25	384	445	No hit	No description
Pfam	PF00847	1.7E-11	384	435	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	2.3E-18	385	443	IPR001471	AP2/ERF domain
SMART	SM00380	3.8E-34	385	449	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	18.966	385	443	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.2E-6	425	445	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007276	Biological Process	gamete generation
GO:0009908	Biological Process	flower development
GO:0010492	Biological Process	maintenance of shoot apical meristem identity
GO:0030154	Biological Process	cell differentiation
GO:0042127	Biological Process	regulation of cell proliferation
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000013	anatomy	cauline leaf
PO:0000037	anatomy	shoot apex
PO:0000230	anatomy	inflorescence meristem
PO:0000293	anatomy	guard cell
PO:0008019	anatomy	leaf lamina base
PO:0009005	anatomy	root
PO:0009006	anatomy	shoot system
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009025	anatomy	vascular leaf
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009052	anatomy	flower pedicel
PO:0020038	anatomy	petiole
PO:0020100	anatomy	hypocotyl
PO:0020137	anatomy	leaf apex
PO:0025022	anatomy	collective leaf structure
PO:0001054	developmental stage	vascular leaf senescent stage
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001081	developmental stage	mature plant embryo stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0004507	developmental stage	plant embryo bilateral stage
PO:0007098	developmental stage	LP.02 two leaves visible stage
PO:0007115	developmental stage	LP.04 four leaves visible stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 555 aa Download sequence Send to blast
MKSFCDNDDN NHSNTTNLLG FSLSSNMMKM GGRGGREAIY SSSTSSAATS SSSVPPQLVV 60 GDNTSNFGVC YGSNPNGGIY SHMSVMPLRS DGSLCLMEAL NRSSHSNHHQ DSSPKVEDFF 120 GTHHNNTSHK EAMDLSLDSL FYNTTHEPNT TTNFQEFFSF PQTRNHEEET RNYGNDPSLT 180 HGGSFNVGVY GEFQQSLSLS MSPGSQSSCI TGSHHHQQNQ NQNHQSQNHQ QISEALVETS 240 VGFETTTMAA AKKKRGQEDV VVVGQKQIVH RKSIDTFGQR TSQYRGVTRH RWTGRYEAHL 300 WDNSFKKEGH SRKGRQVYLG GYDMEEKAAR AYDLAALKYW GPSTHTNFSA ENYQKEIEDM 360 KNMTRQEYVA HLRRKSSGFS RGASIYRGVT RHHQHGRWQA RIGRVAGNKD LYLGTFGTQE 420 EAAEAYDVAA IKFRGTNAVT NFDITRYDVD RIMSSNTLLS GELARRNNNS IVVRNTEDQT 480 ALNAVVEGGS NKEVSTPERL LSFPAIFALP QVNQKMFGSN MGGNMSPWTS NPNAELKTVA 540 LTLPQMPVFA AWADS

Sequence ? help Back to Top

Protein Sequence Length: 555 aa Download sequence Send to blast

MKSFCDNDDN NHSNTTNLLG FSLSSNMMKM GGRGGREAIY SSSTSSAATS SSSVPPQLVV  60
GDNTSNFGVC YGSNPNGGIY SHMSVMPLRS DGSLCLMEAL NRSSHSNHHQ DSSPKVEDFF  120
GTHHNNTSHK EAMDLSLDSL FYNTTHEPNT TTNFQEFFSF PQTRNHEEET RNYGNDPSLT  180
HGGSFNVGVY GEFQQSLSLS MSPGSQSSCI TGSHHHQQNQ NQNHQSQNHQ QISEALVETS  240
VGFETTTMAA AKKKRGQEDV VVVGQKQIVH RKSIDTFGQR TSQYRGVTRH RWTGRYEAHL  300
WDNSFKKEGH SRKGRQVYLG GYDMEEKAAR AYDLAALKYW GPSTHTNFSA ENYQKEIEDM  360
KNMTRQEYVA HLRRKSSGFS RGASIYRGVT RHHQHGRWQA RIGRVAGNKD LYLGTFGTQE  420
EAAEAYDVAA IKFRGTNAVT NFDITRYDVD RIMSSNTLLS GELARRNNNS IVVRNTEDQT  480
ALNAVVEGGS NKEVSTPERL LSFPAIFALP QVNQKMFGSN MGGNMSPWTS NPNAELKTVA  540
LTLPQMPVFA AWADS

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.1556	0.0	flower\| root

Expression -- Microarray ? help Back to Top
Source	ID	E-value
Genevisible	253010_at	0.0
Expression Atlas	AT4G37750	-
AtGenExpress	AT4G37750	-
ATTED-II	AT4G37750	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in floral primordia, in STM-negative region, then in sepal primordia. As sepal develops, progressively confined to a basal core before disappearing. Present in stamen primordia, then confined to a central region as they become stalked and develop locules. Later reduced to procambial cells as stamen mature. From petal primordia, expressed on the lateral edges of developing petals and finally confined to petal epidermis before disappearing. Present in carpel primordia, then in inner side of carpels especially in the placenta. Strong levels in ovules primordia and young ovules, then localized in integuments initiation zone before being confined to inner integument cells that will differentiate into the endothelium. Expressed in the distal half of the funiculus throughout ovule development and later extends into the chalaza. After fertilization, expression shift to the embryo. First on the apical part at the globular stage, then in cotyledons primordia, and later in cotyledons during the torpedo stage. As cotyledons grow out, expression becomes limited to a plane separating adaxial and abaxial parts. Excluded from the embryonic central region (ECR). In seedlings, found in leaf primordia then in central and lateral actively developing regions of extending leaves. {ECO:0000269\|PubMed:10656774, ECO:0000269\|PubMed:8742707, ECO:0000269\|PubMed:9671577}.
Uniprot	TISSUE SPECIFICITY: Mostly expressed in developing flowers. Also present in mature flowers, siliques and seedlings, but not in mature roots, leaves and stems. Expressed in ovules and in vegetative and floral primordia. {ECO:0000269\|PubMed:15988559, ECO:0000269\|PubMed:8742706, ECO:0000269\|PubMed:8742707}.

Functional Description ? help Back to Top
Source	Description
TAIR	ANT is required for control of cell proliferation and encodes a putative transcriptional regulator similar to AP2. Loss of function alleles have reduced fertility, abnormal ovules and abnormal lateral organs. Expressed specifically in the chalaza and in floral organ primordia.
UniProt	Transcription activator that recognizes and binds to the DNA consensus sequence 5'-CAC[AG]N[AT]TNCCNANG-3'. Required for the initiation and growth of ovules integumenta, and for the development of female gametophyte. Plays a critical role in the development of gynoecium marginal tissues (e.g. stigma, style and septa), and in the fusion of carpels and of medial ridges leading to ovule primordia. Also involved in organs initiation and development, including floral organs. Maintains the meristematic competence of cells and consequently sustains expression of cell cycle regulators during organogenesis, thus controlling the final size of each organ by controlling their cell number. Regulates INO autoinduction and expression pattern. As ANT promotes petal cell identity and mediates down-regulation of AG in flower whorl 2, it functions as a class A homeotic gene. {ECO:0000269\|PubMed:10528263, ECO:0000269\|PubMed:10639184, ECO:0000269\|PubMed:10948255, ECO:0000269\|PubMed:11041883, ECO:0000269\|PubMed:12183381, ECO:0000269\|PubMed:12271029, ECO:0000269\|PubMed:12655002, ECO:0000269\|PubMed:8742706, ECO:0000269\|PubMed:8742707, ECO:0000269\|PubMed:9001406, ECO:0000269\|PubMed:9093862, ECO:0000269\|PubMed:9118807}.

Function -- GeneRIF ? help Back to Top
ANT is nuclear localized and that the sequence KKKR (amino acids 252-255) is required for nuclear localization of the protein. [PMID: 16523347] ANT acts in combination with the YABBY gene FILAMENTOUS FLOWER (FIL) to promote organ polarity by up-regulating the expression of the adaxial-specifying HD-ZIP gene PHABULOSA. [PMID: 16714408] SEU and ANT are part of a complex and robust molecular system that coordinates patterning cues and cellular proliferation along the three positional axes of the developing gynoecium. [PMID: 18184731] A combined action of ANT and CYCD3;1 promotes cell proliferation in leaf primordia and increases leaf size. [PMID: 19508432] ANT and AIL6 are important regulators of floral growth and patterning and that they may act downstream of auxin in these processes. [PMID: 19542297] The stk shp1 shp2 ant quadruple mutant ovule lacks integument development as in ant single mutant. [PMID: 20041269] SEUSS (SEU) and AINTEGUMENTA (ANT) encode transcriptional regulators that are critical for the proper formation of ovules from the carpel margin meristem (CMM). [PMID: 22031826] ANT, AIL6 and AIL7 are expressed in distinct domains within the vegetative shoot apical meristem. Triple mutant shoot apical meristems exhibit morphological and cell division defects. [PMID: 22380923] these three transcription factors LFY, ANT and AIL6/PLT3 are redundantly required for flower primordium initiation. [PMID: 23375585] CUC1, CUC2, and AINTEGUMENTA have additive effects on ovule primordia formation. [PMID: 23941199] Overexpression of AtANT in Antirrhinum caused increased flower size via increased petal limb width and tube length. [PMID: 24985495] ANT does not regulate CYCD3;1 during petal growth. [PMID: 25948704] ANT is a novel regulator of salt stress and that ANT binds to the SCABP8 promoter, mediating salt tolerance. [PMID: 26054800] ANT and AIL6 directly induce LFY expression in response to auxin to promote the onset of flower formation. [PMID: 26537561] ANT regulates biological pathways that are critical for cell wall remodeling and defense. [PMID: 27208279]

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00088	SELEX	26531826	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT4G37750.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source	Upstream Regulator (A: Activate/R: Repress)
ATRM	AT1G23420 (A), AT1G55580 (A), AT2G17950 (A), AT5G23000 (A), AT5G62000 (R)

Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source	Target Gene (A: Activate/R: Repress)
ATRM	AT1G23420(A), AT1G69180(R), AT2G34710(A), AT2G45190(A), AT3G54340(A), AT4G00180(A), AT4G18960(R), AT4G27330(A), AT4G34160(A), AT5G60690(A), AT5G61850(A)

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT4G37750

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	ATU40256	0.0	U40256.1 Arabidopsis thaliana ovule development protein (AINTEGUMENTA) mRNA, complete cds.
GenBank	ATU41339	0.0	U41339.1 Arabidopsis thaliana ANT (AINTEGUMENTA) mRNA, complete cds.
GenBank	AY080706	0.0	AY080706.1 Arabidopsis thaliana putative ovule development protein aintegumenta (At4g37750) mRNA, complete cds.
GenBank	AY117207	0.0	AY117207.1 Arabidopsis thaliana putative ovule development protein aintegumenta (At4g37750) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_195489.1	0.0	Integrase-type DNA-binding superfamily protein
Swissprot	Q38914	0.0	ANT_ARATH; AP2-like ethylene-responsive transcription factor ANT
TrEMBL	A0A178V2U9	0.0	A0A178V2U9_ARATH; DRG
STRING	AT4G37750.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM3137	28	63
Representative plant	OGRP112	17	209

Link Out ? help Back to Top
Phytozome	AT4G37750.1
Entrez Gene	829931
iHOP	AT4G37750
wikigenes	AT4G37750

Publications ? help Back to Top
Byzova MV, et al. Arabidopsis STERILE APETALA, a multifunctional gene regulating inflorescence, flower, and ovule development. Genes Dev., 1999. 13(8): p. 1002-14 [PMID:10215627] Krizek BA Ectopic expression of AINTEGUMENTA in Arabidopsis plants results in increased growth of floral organs. Dev. Genet., 1999. 25(3): p. 224-36 [PMID:10528263] Villanueva JM, et al. INNER NO OUTER regulates abaxial- adaxial patterning in Arabidopsis ovules. Genes Dev., 1999. 13(23): p. 3160-9 [PMID:10601041] Mizukami Y,Fischer RL Plant organ size control: AINTEGUMENTA regulates growth and cell numbers during organogenesis. Proc. Natl. Acad. Sci. U.S.A., 2000. 97(2): p. 942-7 [PMID:10639184] Long J,Barton MK Initiation of axillary and floral meristems in Arabidopsis. Dev. Biol., 2000. 218(2): p. 341-53 [PMID:10656774] Broadhvest J,Baker SC,Gasser CS SHORT INTEGUMENTS 2 promotes growth during Arabidopsis reproductive development. Genetics, 2000. 155(2): p. 899-907 [PMID:10835408] Krizek BA,Prost V,Macias A AINTEGUMENTA promotes petal identity and acts as a negative regulator of AGAMOUS. Plant Cell, 2000. 12(8): p. 1357-66 [PMID:10948255] Balasubramanian S,Schneitz K NOZZLE regulates proximal-distal pattern formation, cell proliferation and early sporogenesis during ovule development in Arabidopsis thaliana. Development, 2000. 127(19): p. 4227-38 [PMID:10976054] Liu Z,Franks RG,Klink VP Regulation of gynoecium marginal tissue formation by LEUNIG and AINTEGUMENTA. Plant Cell, 2000. 12(10): p. 1879-92 [PMID:11041883] Nole-Wilson S,Krizek BA DNA binding properties of the Arabidopsis floral development protein AINTEGUMENTA. Nucleic Acids Res., 2000. 28(21): p. 4076-82 [PMID:11058102] Vernoux T,Kronenberger J,Grandjean O,Laufs P,Traas J PIN-FORMED 1 regulates cell fate at the periphery of the shoot apical meristem. Development, 2000. 127(23): p. 5157-65 [PMID:11060241] Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Mizukami Y A matter of size: developmental control of organ size in plants. Curr. Opin. Plant Biol., 2001. 4(6): p. 533-9 [PMID:11641070] Goff SA, et al. A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science, 2002. 296(5565): p. 92-100 [PMID:11935018] Gross-Hardt R,Lenhard M,Laux T WUSCHEL signaling functions in interregional communication during Arabidopsis ovule development. Genes Dev., 2002. 16(9): p. 1129-38 [PMID:12000795] Balasubramanian S,Schneitz K NOZZLE links proximal-distal and adaxial-abaxial pattern formation during ovule development in Arabidopsis thaliana. Development, 2002. 129(18): p. 4291-300 [PMID:12183381] Reiser L,Fischer RL The Ovule and the Embryo Sac. Plant Cell, 1993. 5(10): p. 1291-1301 [PMID:12271029] Krizek BA AINTEGUMENTA utilizes a mode of DNA recognition distinct from that used by proteins containing a single AP2 domain. Nucleic Acids Res., 2003. 31(7): p. 1859-68 [PMID:12655002] Alvarez-Venegas R, et al. ATX-1, an Arabidopsis homolog of trithorax, activates flower homeotic genes. Curr. Biol., 2003. 13(8): p. 627-37 [PMID:12699618] Durfee T, et al. The F-box-containing protein UFO and AGAMOUS participate in antagonistic pathways governing early petal development in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2003. 100(14): p. 8571-6 [PMID:12826617] Hu Y,Xie Q,Chua NH The Arabidopsis auxin-inducible gene ARGOS controls lateral organ size. Plant Cell, 2003. 15(9): p. 1951-61 [PMID:12953103] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Meister RJ, et al. Definition and interactions of a positive regulatory element of the Arabidopsis INNER NO OUTER promoter. Plant J., 2004. 37(3): p. 426-38 [PMID:14731261] Shigyo M,Ito M Analysis of gymnosperm two-AP2-domain-containing genes. Dev. Genes Evol., 2004. 214(3): p. 105-14 [PMID:14986134] Gallois JL,Nora FR,Mizukami Y,Sablowski R WUSCHEL induces shoot stem cell activity and developmental plasticity in the root meristem. Genes Dev., 2004. 18(4): p. 375-80 [PMID:15004006] Jack T Molecular and genetic mechanisms of floral control. Plant Cell, 2004. 16 Suppl: p. S1-17 [PMID:15020744] Skinner DJ,Hill TA,Gasser CS Regulation of ovule development. Plant Cell, 2004. 16 Suppl: p. S32-45 [PMID:15131247] Magnani E,Sj From endonucleases to transcription factors: evolution of the AP2 DNA binding domain in plants. Plant Cell, 2004. 16(9): p. 2265-77 [PMID:15319480] Sieber P, et al. Pattern formation during early ovule development in Arabidopsis thaliana. Dev. Biol., 2004. 273(2): p. 321-34 [PMID:15328016] Kajiwara T,Furutani M,Hibara K,Tasaka M The GURKE gene encoding an acetyl-CoA carboxylase is required for partitioning the embryo apex into three subregions in Arabidopsis. Plant Cell Physiol., 2004. 45(9): p. 1122-8 [PMID:15509834] Rieu I,Bots M,Mariani C,Weterings KA Isolation and expression analysis of a tobacco AINTEGUMENTA ortholog (NtANTL). Plant Cell Physiol., 2005. 46(5): p. 803-5 [PMID:15746156] Clay NK,Nelson T The recessive epigenetic swellmap mutation affects the expression of two step II splicing factors required for the transcription of the cell proliferation gene STRUWWELPETER and for the timing of cell cycle arrest in the Arabidopsis leaf. Plant Cell, 2005. 17(7): p. 1994-2008 [PMID:15937226] Nole-Wilson S,Tranby TL,Krizek BA AINTEGUMENTA-like (AIL) genes are expressed in young tissues and may specify meristematic or division-competent states. Plant Mol. Biol., 2005. 57(5): p. 613-28 [PMID:15988559] Kim S,Soltis PS,Wall K,Soltis DE Phylogeny and domain evolution in the APETALA2-like gene family. Mol. Biol. Evol., 2006. 23(1): p. 107-20 [PMID:16151182] Horiguchi G,Ferjani A,Fujikura U,Tsukaya H Coordination of cell proliferation and cell expansion in the control of leaf size in Arabidopsis thaliana. J. Plant Res., 2006. 119(1): p. 37-42 [PMID:16284709] Nakano T,Suzuki K,Fujimura T,Shinshi H Genome-wide analysis of the ERF gene family in Arabidopsis and rice. Plant Physiol., 2006. 140(2): p. 411-32 [PMID:16407444] Keller T,Abbott J,Moritz T,Doerner P Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem cell niche and modulates vegetative development. Plant Cell, 2006. 18(3): p. 598-611 [PMID:16473968] Krizek BA,Sulli C Mapping sequences required for nuclear localization and the transcriptional activation function of the Arabidopsis protein AINTEGUMENTA. Planta, 2006. 224(3): p. 612-21 [PMID:16523347] Nole-Wilson S,Krizek BA AINTEGUMENTA contributes to organ polarity and regulates growth of lateral organs in combination with YABBY genes. Plant Physiol., 2006. 141(3): p. 977-87 [PMID:16714408] Hu Y,Poh HM,Chua NH The Arabidopsis ARGOS-LIKE gene regulates cell expansion during organ growth. Plant J., 2006. 47(1): p. 1-9 [PMID:16824178] Balanz Patterning the female side of Arabidopsis: the importance of hormones. J. Exp. Bot., 2006. 57(13): p. 3457-69 [PMID:17023565] Kang J,Mizukami Y,Wang H,Fowke L,Dengler NG Modification of cell proliferation patterns alters leaf vein architecture in Arabidopsis thaliana. Planta, 2007. 226(5): p. 1207-18 [PMID:17569988] Wijeratne AJ, et al. Differential gene expression in Arabidopsis wild-type and mutant anthers: insights into anther cell differentiation and regulatory networks. Plant J., 2007. 52(1): p. 14-29 [PMID:17666023] Brambilla V, et al. Genetic and molecular interactions between BELL1 and MADS box factors support ovule development in Arabidopsis. Plant Cell, 2007. 19(8): p. 2544-56 [PMID:17693535] Dewitte W, et al. Arabidopsis CYCD3 D-type cyclins link cell proliferation and endocycles and are rate-limiting for cytokinin responses. Proc. Natl. Acad. Sci. U.S.A., 2007. 104(36): p. 14537-42 [PMID:17726100] Azhakanandam S,Nole-Wilson S,Bao F,Franks RG SEUSS and AINTEGUMENTA mediate patterning and ovule initiation during gynoecium medial domain development. Plant Physiol., 2008. 146(3): p. 1165-81 [PMID:18184731] Sicard A,Petit J,Mouras A,Chevalier C,Hernould M Meristem activity during flower and ovule development in tomato is controlled by the mini zinc finger gene INHIBITOR OF MERISTEM ACTIVITY. Plant J., 2008. 55(3): p. 415-27 [PMID:18410478] Guan H,Kang D,Fan M,Chen Z,Qu LJ Overexpression of a new putative membrane protein gene AtMRB1 results in organ size enlargement in Arabidopsis. 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