PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G34410.1
Common NameERF109, F10M10.180, RRTF1
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 268aa    MW: 29446.7 Da    PI: 6.2918
Description redox responsive transcription factor 1
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G34410.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2   2 gykGVrwdkkrgrWvAeIrdpsengkr.krfslgkfgtaeeAakaaiaarkkleg 55 
                  gy+GVr+++ +g+++AeIrdp+    r +r++lg+f tae+Aa+a+++a+  ++g
                  8********.**********83....57*********************987776 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541711.11E-21135193IPR016177DNA-binding domain
SMARTSM003802.1E-37135198IPR001471AP2/ERF domain
PROSITE profilePS5103224.012135192IPR001471AP2/ERF domain
PfamPF008473.7E-12135183IPR001471AP2/ERF domain
CDDcd000182.09E-21136192No hitNo description
Gene3DG3DSA:3.30.730.106.0E-32136192IPR001471AP2/ERF domain
PRINTSPR003671.4E-11136147IPR001471AP2/ERF domain
PRINTSPR003671.4E-11158174IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0001944Biological Processvasculature development
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009873Biological Processethylene-activated signaling pathway
GO:0010200Biological Processresponse to chitin
GO:0050832Biological Processdefense response to fungus
GO:0051301Biological Processcell division
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000230anatomyinflorescence meristem
PO:0000293anatomyguard cell
PO:0008019anatomyleaf lamina base
PO:0009009anatomyplant embryo
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0001185developmental stageplant embryo globular stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007064developmental stageLP.12 twelve leaves visible stage
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 268 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
No. Start End Sequence
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
At.489360.0bud| floral meristem| leaf| root
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT4G34410-
Functional Description ? help Back to Top
Source Description
TAIRencodes a member of the ERF (ethylene response factor) subfamily B-3 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are 18 members in this subfamily including ATERF-1, ATERF-2, AND ATERF-5.
UniProtProbably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250}.
Function -- GeneRIF ? help Back to Top
  1. RRTF1 has a role in regulating redox homeostasis related to photosynthetic stress. [RRTF1]
    [PMID: 18829981]
  2. ERF109 mediates cross-talk between jasmonic acid and auxin biosynthesis during lateral root formation.
    [PMID: 25524530]
  3. inactivation of RRTF1 restricts and overexpression promotes reactive oxygen species (ROS) accumulation in response to stress.
    [PMID: 25882345]
  4. RRTF1 and/or RRTF1-mediated ROS signaling induce stress responses in an age-dependent manner, and the age-dependent alteration in the RRTF1 function might be important for plant's acclimation to the stress environment.[RRTF1]
    [PMID: 26479402]
  5. Results show that the RRTF1 promoter is sufficient for the control of both activation and adaptation to salt stress. As constitutive expression of RRTF1 turned out to be detrimental to the plant, results propose that promoter-regulated adaptation evolved as a protection mechanism to balance the beneficial effects of short-term gene activation and the detrimental effects of long-term gene expression.
    [PMID: 30734200]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G34410
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF3250910.0AF325091.1 Arabidopsis thaliana putative protein (F10M10.180) mRNA, complete cds.
GenBankAL0355210.0AL035521.1 Arabidopsis thaliana DNA chromosome 4, BAC clone F10M10 (ESSA project).
GenBankAL1615850.0AL161585.2 Arabidopsis thaliana DNA chromosome 4, contig fragment No. 81.
GenBankAY0641510.0AY064151.1 Arabidopsis thaliana AT4g34410/F10M10_180 mRNA, complete cds.
GenBankAY1207000.0AY120700.1 Arabidopsis thaliana AT4g34410/F10M10_180 mRNA, complete cds.
GenBankCP0026870.0CP002687.1 Arabidopsis thaliana chromosome 4 sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_195167.10.0redox responsive transcription factor 1
SwissprotQ9SZ060.0EF109_ARATH; Ethylene-responsive transcription factor ERF109
STRINGAT4G34410.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  2. M
    Brassinosteroids promote root growth in Arabidopsis.
    Plant Physiol., 2003. 133(3): p. 1261-71
  3. Yamada K, et al.
    Empirical analysis of transcriptional activity in the Arabidopsis genome.
    Science, 2003. 302(5646): p. 842-6
  4. Chang S,Pikaard CS
    Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation.
    J. Biol. Chem., 2005. 280(1): p. 796-804
  5. Suzuki N, et al.
    Enhanced tolerance to environmental stress in transgenic plants expressing the transcriptional coactivator multiprotein bridging factor 1c.
    Plant Physiol., 2005. 139(3): p. 1313-22
  6. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  7. Tang M,Sun J,Liu Y,Chen F,Shen S
    Isolation and functional characterization of the JcERF gene, a putative AP2/EREBP domain-containing transcription factor, in the woody oil plant Jatropha curcas.
    Plant Mol. Biol., 2007. 63(3): p. 419-28
  8. Lee J, et al.
    Analysis of transcription factor HY5 genomic binding sites revealed its hierarchical role in light regulation of development.
    Plant Cell, 2007. 19(3): p. 731-49
  9. Kong H, et al.
    Patterns of gene duplication in the plant SKP1 gene family in angiosperms: evidence for multiple mechanisms of rapid gene birth.
    Plant J., 2007. 50(5): p. 873-85
  10. Libault M,Wan J,Czechowski T,Udvardi M,Stacey G
    Identification of 118 Arabidopsis transcription factor and 30 ubiquitin-ligase genes responding to chitin, a plant-defense elicitor.
    Mol. Plant Microbe Interact., 2007. 20(8): p. 900-11
  11. Wang Z, et al.
    Identification and characterization of COI1-dependent transcription factor genes involved in JA-mediated response to wounding in Arabidopsis plants.
    Plant Cell Rep., 2008. 27(1): p. 125-35
  12. Cartagena JA, et al.
    The Arabidopsis SDG4 contributes to the regulation of pollen tube growth by methylation of histone H3 lysines 4 and 36 in mature pollen.
    Dev. Biol., 2008. 315(2): p. 355-68
  13. Veyres N, et al.
    The Arabidopsis sweetie mutant is affected in carbohydrate metabolism and defective in the control of growth, development and senescence.
    Plant J., 2008. 55(4): p. 665-86
  14. Nagano AJ,Fukao Y,Fujiwara M,Nishimura M,Hara-Nishimura I
    Antagonistic jacalin-related lectins regulate the size of ER body-type beta-glucosidase complexes in Arabidopsis thaliana.
    Plant Cell Physiol., 2008. 49(6): p. 969-80
  15. Abercrombie JM, et al.
    Transcriptional responses of Arabidopsis thaliana plants to As (V) stress.
    BMC Plant Biol., 2008. 8: p. 87
  16. Jakoby MJ, et al.
    Transcriptional profiling of mature Arabidopsis trichomes reveals that NOECK encodes the MIXTA-like transcriptional regulator MYB106.
    Plant Physiol., 2008. 148(3): p. 1583-602
  17. Khandelwal A,Elvitigala T,Ghosh B,Quatrano RS
    Arabidopsis transcriptome reveals control circuits regulating redox homeostasis and the role of an AP2 transcription factor.
    Plant Physiol., 2008. 148(4): p. 2050-8
  18. Huibers RP,de Jong M,Dekter RW,Van den Ackerveken G
    Disease-specific expression of host genes during downy mildew infection of Arabidopsis.
    Mol. Plant Microbe Interact., 2009. 22(9): p. 1104-15
  19. Pandey SP,Roccaro M,Sch
    Transcriptional reprogramming regulated by WRKY18 and WRKY40 facilitates powdery mildew infection of Arabidopsis.
    Plant J., 2010. 64(6): p. 912-23
  20. Ou B, et al.
    A high-throughput screening system for Arabidopsis transcription factors and its application to Med25-dependent transcriptional regulation.
    Mol Plant, 2011. 4(3): p. 546-55
  21. Mehterov N, et al.
    Oxidative stress provokes distinct transcriptional responses in the stress-tolerant atr7 and stress-sensitive loh2 Arabidopsis thaliana mutants as revealed by multi-parallel quantitative real-time PCR analysis of ROS marker and antioxidant genes.
    Plant Physiol. Biochem., 2012. 59: p. 20-9
  22. Etchells JP,Provost CM,Turner SR
    Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling.
    PLoS Genet., 2012. 8(11): p. e1002997
  23. Schweizer F,Bodenhausen N,Lassueur S,Masclaux FG,Reymond P
    Differential Contribution of Transcription Factors to Arabidopsis thaliana Defense Against Spodoptera littoralis.
    Front Plant Sci, 2013. 4: p. 13
  24. Cai XT, et al.
    Arabidopsis ERF109 mediates cross-talk between jasmonic acid and auxin biosynthesis during lateral root formation.
    Nat Commun, 2014. 5: p. 5833
  25. Matsuo M, et al.
    High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots.
    Mol Plant, 2015. 8(8): p. 1253-73
  26. Matsuo M,Oelmüller R
    REDOX RESPONSIVE TRANSCRIPTION FACTOR1 is involved in age-dependent and systemic stress signaling.
    Plant Signal Behav, 2015. 10(11): p. e1051279
  27. Bertea CM,Narayana R,Agliassa C,Rodgers CT,Maffei ME
    Geomagnetic Field (Gmf) and Plant Evolution: Investigating the Effects of Gmf Reversal on Arabidopsis thaliana Development and Gene Expression.
    J Vis Exp, 2018.
  28. Bahieldin A, et al.
    Ethylene responsive transcription factor ERF109 retards PCD and improves salt tolerance in plant.
    BMC Plant Biol., 2016. 16(1): p. 216
  29. Huang D,Lin W,Deng B,Ren Y,Miao Y
    Dual-Located WHIRLY1 Interacting with LHCA1 Alters Photochemical Activities of Photosystem I and Is Involved in Light Adaptation in Arabidopsis.
    Int J Mol Sci, 2018.
  30. Kong X, et al.
    PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis.
    Cell Rep, 2018. 22(5): p. 1350-1363
  31. Soliman ERS,Meyer P
    Responsiveness and Adaptation to Salt Stress of the REDOX-RESPONSIVE TRANSCRIPTION FACTOR 1 (RRTF1) Gene are Controlled by its Promoter.
    Mol. Biotechnol., 2019. 61(4): p. 254-260