PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT4G25470.1
Common NameATCBF2, CBF2, DREB1C, ERF030, FTQ4, M7J2.161
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family ERF
Protein Properties Length: 216aa    MW: 24264.2 Da    PI: 4.752
Description C-repeat/DRE binding factor 2
Gene Model
Gene Model ID Type Source Coding Sequence
AT4G25470.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
          AP2  2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                  y+GVr++  +g+Wv+e+r+p   +k++r++lg+f tae+Aa+a++ a+ +l+g
                 69****999.7*********8...347*************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008471.9E-134999IPR001471AP2/ERF domain
CDDcd000182.68E-3349109No hitNo description
SMARTSM003807.1E-3350113IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.7E-3250109IPR001471AP2/ERF domain
PROSITE profilePS5103221.98350107IPR001471AP2/ERF domain
SuperFamilySSF541711.11E-2150109IPR016177DNA-binding domain
PRINTSPR003671.1E-95162IPR001471AP2/ERF domain
PRINTSPR003671.1E-97389IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009631Biological Processcold acclimation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000013anatomycauline leaf
PO:0000037anatomyshoot apex
PO:0000293anatomyguard cell
PO:0006503anatomyfruit abscission zone
PO:0009025anatomyvascular leaf
PO:0009052anatomyflower pedicel
PO:0020137anatomyleaf apex
PO:0025022anatomycollective leaf structure
PO:0007095developmental stageLP.08 eight leaves visible stage
PO:0007098developmental stageLP.02 two leaves visible stage
PO:0007103developmental stageLP.10 ten leaves visible stage
PO:0007115developmental stageLP.04 four leaves visible stage
PO:0007123developmental stageLP.06 six leaves visible stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 216 aa     Download sequence    Send to blast
3D Structure ? help Back to Top
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5wx9_A3e-14481061271Ethylene-responsive transcription factor ERF096
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Expression -- Microarray ? help Back to Top
Source ID E-value
Expression AtlasAT4G25470-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in leaves and roots. {ECO:0000269|PubMed:9735350}.
Functional Description ? help Back to Top
Source Description
TAIREncodes a member of the DREB subfamily A-1 of ERF/AP2 transcription factor family (CBF2). The protein contains one AP2 domain. There are six members in this subfamily, including CBF1, CBF2, and CBF3. This gene is involved in response to low temperature, abscisic acid, and circadian rhythm. Overexpressing this gene leads to increased freeze tolerance and induces the expression level of 85 cold-induced genes and reduces the expression level of 8 cold-repressed genes, which constitute the CBF2 regulon. Mutations in CBF2 increases the expression level of CBF1 and CBF3, suggesting that this gene may be involved in a negative regulatory or feedback circuit of the CBF pathway.
UniProtTranscriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation. {ECO:0000269|PubMed:11798174, ECO:0000269|PubMed:16244146}.
Function -- GeneRIF ? help Back to Top
  1. We explored the regulation of CBF1-3 by the circadian clock.
    [PMID: 15728337]
  2. The low freezing tolerance of FTQ4-Cvi (FREEZING TOLERANCE QTL 4) alleles was associated with a deletion of the promoter region of Cvi CBF2, and with low RNA expression of CBF2 and of several CBF target genes.
    [PMID: 16244146]
  3. CBF1 and CBF3, but not CBF2 have a concerted additive effect to induce the whole CBF regulon and the complete development of cold acclimation
    [PMID: 18093929]
  4. Important evolutionary changes in CBF1, -2, and -3 may have primarily occurred at the level of gene regulation as well as in protein function.
    [PMID: 18990244]
  5. SOC1 Directly Represses the Expression of CBF2 Genes.
    [PMID: 19825833]
  6. PIF7 functions as a transcriptional repressor for DREB1C expression and its activity is regulated by PIF7-interacting factors TIMING OF CAB EXPRESSION1 and Phytochrome B.
    [PMID: 19837816]
  7. These results indicate that overexpression of CBF2 not only increases frost tolerance, but also affects other developmental processes.
    [PMID: 19854800]
  8. Overexpression of CBF2 in Arabidopsis suppressed the responsiveness of leaf tissues to ethylene compared with that in wild-type plants, as manifested in significantly delayed senescence and chlorophyll degradation.
    [PMID: 20636906]
  9. Transcriptional changes in cell wall metabolism-related components under overexpression of a key transcription factor for freezing tolerance, CBF2, were identified.
    [PMID: 21611181]
  10. Studies indicate that DREB1A (CBF3), DREB1B (CBF1) and DREB1C (CBF2) play an important role in increasing stress tolerance.
    [PMID: 23271026]
  11. A major locus harboring three cold-responsive transcription factor genes CBF1, was identified.
    [PMID: 23721132]
  12. Data indicate that the C-repeat binding factor (CBF) locus includes three genes - CBF1, CBF2 and CBF3 (AT4G25480) - that are induced by low temperature and encode transcription factors.
    [PMID: 26369909]
  13. RDM4 is important for Pol II occupancy at the promoters of CBF2 and CBF3.
    [PMID: 26522658]
  14. the three CBF genes together are required for cold acclimation and freezing tolerance.
    [PMID: 27252305]
  15. This study reveals the essential functions of C-repeat binding factors (CBF) in chilling stress response and cold acclimation, as well as defines a set of genes as CBF regulon.
    [PMID: 27353960]
  16. CBFs play an important role in the trade-off between cold tolerance and plant growth through the precise regulation of COR genes in the complicated transcriptional network.
    [PMID: 28009483]
  17. Here we present results establishing that the difference in CBF2 alleles contributes to the difference in freezing tolerance between two ecotypes.
    [PMID: 30517145]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
Motif logo
Cis-element ? help Back to Top
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By cold stress. {ECO:0000269|PubMed:9735350, ECO:0000269|PubMed:9952441}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT2G22300 (A), AT3G23250 (R), AT3G26744 (A), AT5G13790 (R), AT5G59820 (R), AT5G61270 (R)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G04240(A), AT1G13260(A), AT1G32640(R), AT1G43160(A), AT1G46768(A), AT1G77120(A), AT2G39030(A), AT2G42540(A), AT3G50970(A), AT4G25480(R), AT4G25490(R), AT5G15960(A), AT5G17490(A), AT5G52310(A)
Regulation -- Hormone ? help Back to Top
Source Hormone
AHDabscisic acid, ethylene, Jasmonic acid, salicylic acid
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT4G25470
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0077890.0AB007789.1 Arabidopsis thaliana mRNA for DREB1C, complete cds.
GenBankAB0138170.0AB013817.1 Arabidopsis thaliana gene for DREB1C, complete cds.
GenBankAF0629250.0AF062925.1 Arabidopsis thaliana transcriptional activator CBF1 homolog (CBF3) gene, complete cds.
GenBankAF0746010.0AF074601.1 Arabidopsis thaliana CRT/DRE binding factor 2 (CBF2) mRNA, complete cds.
GenBankAL0221970.0AL022197.2 Arabidopsis thaliana DNA chromosome 4, P1 clone M7J2 (ESSA project).
GenBankAL0793500.0AL079350.1 Arabidopsis thaliana DNA chromosome 4, BAC clone T30C3 (ESSA project).
GenBankAL1615630.0AL161563.2 Arabidopsis thaliana DNA chromosome 4, contig fragment No. 63.
GenBankBT0289910.0BT028991.1 Arabidopsis thaliana At4g25470 mRNA, complete cds.
GenBankCP0026870.0CP002687.1 Arabidopsis thaliana chromosome 4 sequence.
GenBankEF5230380.0EF523038.1 Arabidopsis thaliana ecotype Yo-0 C-repeat binding factor 2 (CBF2) mRNA, complete cds.
GenBankEF5230400.0EF523040.1 Arabidopsis thaliana ecotype Ak-1 C-repeat binding factor 2 (CBF2) mRNA, complete cds.
GenBankFJ1693040.0FJ169304.1 Arabidopsis thaliana ecotype Ll-0 DRE/CRT-binding factor 2 (CBF2/DREB1c) gene, complete cds.
GenBankFJ1693050.0FJ169305.1 Arabidopsis thaliana ecotype Spr1-2 DRE/CRT-binding factor 2 (CBF2/DREB1c) gene, complete cds.
GenBankFJ1693060.0FJ169306.1 Arabidopsis thaliana ecotype Sf-1 DRE/CRT-binding factor 2 (CBF2/DREB1c) gene, complete cds.
GenBankFJ4912430.0FJ491243.1 Arabis pumila CBF2 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_567719.11e-163C-repeat/DRE binding factor 2
SwissprotQ9SYS61e-165DRE1C_ARATH; Dehydration-responsive element-binding protein 1C
TrEMBLB2BIW91e-162B2BIW9_ARATH; C-repeat binding factor 2
STRINGAT4G25470.11e-163(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP6161718
Publications ? help Back to Top
  1. Knight H,Veale EL,Warren GJ,Knight MR
    The sfr6 mutation in Arabidopsis suppresses low-temperature induction of genes dependent on the CRT/DRE sequence motif.
    Plant Cell, 1999. 11(5): p. 875-86
  2. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
  3. Sakuma Y, et al.
    DNA-binding specificity of the ERF/AP2 domain of Arabidopsis DREBs, transcription factors involved in dehydration- and cold-inducible gene expression.
    Biochem. Biophys. Res. Commun., 2002. 290(3): p. 998-1009
  4. Hao D,Yamasaki K,Sarai A,Ohme-Takagi M
    Determinants in the sequence specific binding of two plant transcription factors, CBF1 and NtERF2, to the DRE and GCC motifs.
    Biochemistry, 2002. 41(13): p. 4202-8
  5. Guo Y,Xiong L,Ishitani M,Zhu JK
    An Arabidopsis mutation in translation elongation factor 2 causes superinduction of CBF/DREB1 transcription factor genes but blocks the induction of their downstream targets under low temperatures.
    Proc. Natl. Acad. Sci. U.S.A., 2002. 99(11): p. 7786-91
  6. Gong Z, et al.
    RNA helicase-like protein as an early regulator of transcription factors for plant chilling and freezing tolerance.
    Proc. Natl. Acad. Sci. U.S.A., 2002. 99(17): p. 11507-12
  7. Fowler S,Thomashow MF
    Arabidopsis transcriptome profiling indicates that multiple regulatory pathways are activated during cold acclimation in addition to the CBF cold response pathway.
    Plant Cell, 2002. 14(8): p. 1675-90
  8. Choi DW,Rodriguez EM,Close TJ
    Barley Cbf3 gene identification, expression pattern, and map location.
    Plant Physiol., 2002. 129(4): p. 1781-7
  9. Haake V, et al.
    Transcription factor CBF4 is a regulator of drought adaptation in Arabidopsis.
    Plant Physiol., 2002. 130(2): p. 639-48
  10. Dubouzet JG, et al.
    OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression.
    Plant J., 2003. 33(4): p. 751-63
  11. Shen YG, et al.
    An EREBP/AP2-type protein in Triticum aestivum was a DRE-binding transcription factor induced by cold, dehydration and ABA stress.
    Theor. Appl. Genet., 2003. 106(5): p. 923-30
  12. Chinnusamy V, et al.
    ICE1: a regulator of cold-induced transcriptome and freezing tolerance in Arabidopsis.
    Genes Dev., 2003. 17(8): p. 1043-54
  13. Boyce JM, et al.
    The sfr6 mutant of Arabidopsis is defective in transcriptional activation via CBF/DREB1 and DREB2 and shows sensitivity to osmotic stress.
    Plant J., 2003. 34(4): p. 395-406
  14. Zarka DG,Vogel JT,Cook D,Thomashow MF
    Cold induction of Arabidopsis CBF genes involves multiple ICE (inducer of CBF expression) promoter elements and a cold-regulatory circuit that is desensitized by low temperature.
    Plant Physiol., 2003. 133(2): p. 910-8
  15. Novillo F,Alonso JM,Ecker JR,Salinas J
    CBF2/DREB1C is a negative regulator of CBF1/DREB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2004. 101(11): p. 3985-90
  16. Rohde P,Hincha DK,Heyer AG
    Heterosis in the freezing tolerance of crosses between two Arabidopsis thaliana accessions (Columbia-0 and C24) that show differences in non-acclimated and acclimated freezing tolerance.
    Plant J., 2004. 38(5): p. 790-9
  17. Zhang JZ,Creelman RA,Zhu JK
    From laboratory to field. Using information from Arabidopsis to engineer salt, cold, and drought tolerance in crops.
    Plant Physiol., 2004. 135(2): p. 615-21
  18. Knight H,Zarka DG,Okamoto H,Thomashow MF,Knight MR
    Abscisic acid induces CBF gene transcription and subsequent induction of cold-regulated genes via the CRT promoter element.
    Plant Physiol., 2004. 135(3): p. 1710-7
  19. Gilmour SJ,Fowler SG,Thomashow MF
    Arabidopsis transcriptional activators CBF1, CBF2, and CBF3 have matching functional activities.
    Plant Mol. Biol., 2004. 54(5): p. 767-81
  20. Cook D,Fowler S,Fiehn O,Thomashow MF
    A prominent role for the CBF cold response pathway in configuring the low-temperature metabolome of Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2004. 101(42): p. 15243-8
  21. Wang X, et al.
    Isolation and molecular characterization of a new CRT binding factor gene from Capsella bursa-pastoris.
    J. Biochem. Mol. Biol., 2004. 37(5): p. 538-45
  22. Jackson MW,Stinchcombe JR,Korves TM,Schmitt J
    Costs and benefits of cold tolerance in transgenic Arabidopsis thaliana.
    Mol. Ecol., 2004. 13(11): p. 3609-15
  23. Wang X, et al.
    Molecular cloning and characterization of a CBF gene from Capsella bursa-pastoris.
    DNA Seq., 2004. 15(3): p. 180-7
  24. Xiong L,Lee H,Huang R,Zhu JK
    A single amino acid substitution in the Arabidopsis FIERY1/HOS2 protein confers cold signaling specificity and lithium tolerance.
    Plant J., 2004. 40(4): p. 536-45
  25. Gong Z, et al.
    A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis.
    Plant Cell, 2005. 17(1): p. 256-67
  26. Vogel JT,Zarka DG,Van Buskirk HA,Fowler SG,Thomashow MF
    Roles of the CBF2 and ZAT12 transcription factors in configuring the low temperature transcriptome of Arabidopsis.
    Plant J., 2005. 41(2): p. 195-211
  27. Fowler SG,Cook D,Thomashow MF
    Low temperature induction of Arabidopsis CBF1, 2, and 3 is gated by the circadian clock.
    Plant Physiol., 2005. 137(3): p. 961-8
  28. Zhu J, et al.
    HOS10 encodes an R2R3-type MYB transcription factor essential for cold acclimation in plants.
    Proc. Natl. Acad. Sci. U.S.A., 2005. 102(28): p. 9966-71
  29. Cao S,Ye M,Jiang S
    Involvement of GIGANTEA gene in the regulation of the cold stress response in Arabidopsis.
    Plant Cell Rep., 2005. 24(11): p. 683-90
  30. Alonso-Blanco C, et al.
    Genetic and molecular analyses of natural variation indicate CBF2 as a candidate gene for underlying a freezing tolerance quantitative trait locus in Arabidopsis.
    Plant Physiol., 2005. 139(3): p. 1304-12
  31. Vergnolle C, et al.
    The cold-induced early activation of phospholipase C and D pathways determines the response of two distinct clusters of genes in Arabidopsis cell suspensions.
    Plant Physiol., 2005. 139(3): p. 1217-33
  32. Nakano T,Suzuki K,Fujimura T,Shinshi H
    Genome-wide analysis of the ERF gene family in Arabidopsis and rice.
    Plant Physiol., 2006. 140(2): p. 411-32
  33. Zhao TJ, et al.
    Regulating the drought-responsive element (DRE)-mediated signaling pathway by synergic functions of trans-active and trans-inactive DRE binding factors in Brassica napus.
    J. Biol. Chem., 2006. 281(16): p. 10752-9
  34. D'Angelo C, et al.
    Alternative complex formation of the Ca-regulated protein kinase CIPK1 controls abscisic acid-dependent and independent stress responses in Arabidopsis.
    Plant J., 2006. 48(6): p. 857-72
  35. Miura K, et al.
    SIZ1-mediated sumoylation of ICE1 controls CBF3/DREB1A expression and freezing tolerance in Arabidopsis.
    Plant Cell, 2007. 19(4): p. 1403-14
  36. Stockinger EJ,Skinner JS,Gardner KG,Francia E,Pecchioni N
    Expression levels of barley Cbf genes at the Frost resistance-H2 locus are dependent upon alleles at Fr-H1 and Fr-H2.
    Plant J., 2007. 51(2): p. 308-21
  37. Pino MT, et al.
    Use of a stress inducible promoter to drive ectopic AtCBF expression improves potato freezing tolerance while minimizing negative effects on tuber yield.
    Plant Biotechnol. J., 2007. 5(5): p. 591-604
  38. Franklin KA,Whitelam GC
    Light-quality regulation of freezing tolerance in Arabidopsis thaliana.
    Nat. Genet., 2007. 39(11): p. 1410-3
  39. Hill K,Wang H,Perry SE
    A transcriptional repression motif in the MADS factor AGL15 is involved in recruitment of histone deacetylase complex components.
    Plant J., 2008. 53(1): p. 172-85
  40. Chung S,Parish RW
    Combinatorial interactions of multiple cis-elements regulating the induction of the Arabidopsis XERO2 dehydrin gene by abscisic acid and cold.
    Plant J., 2008. 54(1): p. 15-29
  41. Novillo F,Medina J,Salinas J
    Arabidopsis CBF1 and CBF3 have a different function than CBF2 in cold acclimation and define different gene classes in the CBF regulon.
    Proc. Natl. Acad. Sci. U.S.A., 2007. 104(52): p. 21002-7
  42. Pennycooke JC, et al.
    The low temperature-responsive, Solanum CBF1 genes maintain high identity in their upstream regions in a genomic environment undergoing gene duplications, deletions, and rearrangements.
    Plant Mol. Biol., 2008. 67(5): p. 483-97
  43. Magome H,Yamaguchi S,Hanada A,Kamiya Y,Oda K
    The DDF1 transcriptional activator upregulates expression of a gibberellin-deactivating gene, GA2ox7, under high-salinity stress in Arabidopsis.
    Plant J., 2008. 56(4): p. 613-26
  44. Lin YH, et al.
    Molecular population genetics and gene expression analysis of duplicated CBF genes of Arabidopsis thaliana.
    BMC Plant Biol., 2008. 8: p. 111
  45. Eckardt NA
    CAMTA proteins: a direct link between calcium signals and cold acclimation?
    Plant Cell, 2009. 21(3): p. 697
  46. Doherty CJ,Van Buskirk HA,Myers SJ,Thomashow MF
    Roles for Arabidopsis CAMTA transcription factors in cold-regulated gene expression and freezing tolerance.
    Plant Cell, 2009. 21(3): p. 972-84
  47. Navarro M, et al.
    Complementary regulation of four Eucalyptus CBF genes under various cold conditions.
    J. Exp. Bot., 2009. 60(9): p. 2713-24
  48. Seo E, et al.
    Crosstalk between cold response and flowering in Arabidopsis is mediated through the flowering-time gene SOC1 and its upstream negative regulator FLC.
    Plant Cell, 2009. 21(10): p. 3185-97
  49. Kidokoro S, et al.
    The phytochrome-interacting factor PIF7 negatively regulates DREB1 expression under circadian control in Arabidopsis.
    Plant Physiol., 2009. 151(4): p. 2046-57
  50. Sharabi-Schwager M,Lers A,Samach A,Guy CL,Porat R
    Overexpression of the CBF2 transcriptional activator in Arabidopsis delays leaf senescence and extends plant longevity.
    J. Exp. Bot., 2010. 61(1): p. 261-73
  51. Sharabi-Schwager M,Samach A,Porat R
    Overexpression of the CBF2 transcriptional activator in Arabidopsis counteracts hormone activation of leaf senescence.
    Plant Signal Behav, 2010. 5(3): p. 296-9
  52. Diallo A,Kane N,Agharbaoui Z,Badawi M,Sarhan F
    Heterologous expression of wheat VERNALIZATION 2 (TaVRN2) gene in Arabidopsis delays flowering and enhances freezing tolerance.
    PLoS ONE, 2010. 5(1): p. e8690
  53. Dong CJ,Liu JY
    The Arabidopsis EAR-motif-containing protein RAP2.1 functions as an active transcriptional repressor to keep stress responses under tight control.
    BMC Plant Biol., 2010. 10: p. 47
  54. Sharabi-Schwager M,Samach A,Porat R
    Overexpression of the CBF2 transcriptional activator in Arabidopsis suppresses the responsiveness of leaf tissue to the stress hormone ethylene.
    Plant Biol (Stuttg), 2010. 12(4): p. 630-8
  55. Pavangadkar K,Thomashow MF,Triezenberg SJ
    Histone dynamics and roles of histone acetyltransferases during cold-induced gene regulation in Arabidopsis.
    Plant Mol. Biol., 2010. 74(1-2): p. 183-200
  56. Cantrel C, et al.
    Nitric oxide participates in cold-responsive phosphosphingolipid formation and gene expression in Arabidopsis thaliana.
    New Phytol., 2011. 189(2): p. 415-27
  57. Medina J,Catal
    The CBFs: three arabidopsis transcription factors to cold acclimate.
    Plant Sci., 2011. 180(1): p. 3-11
  58. Gery C, et al.
    Natural variation in the freezing tolerance of Arabidopsis thaliana: effects of RNAi-induced CBF depletion and QTL localisation vary among accessions.
    Plant Sci., 2011. 180(1): p. 12-23
  59. Dong MA,Farr
    Circadian clock-associated 1 and late elongated hypocotyl regulate expression of the C-repeat binding factor (CBF) pathway in Arabidopsis.
    Proc. Natl. Acad. Sci. U.S.A., 2011. 108(17): p. 7241-6
  60. Hu P,Maiti T
    A nonparametric mean-variance smoothing method to assess Arabidopsis cold stress transcriptional regulator CBF2 overexpression microarray data.
    PLoS ONE, 2011. 6(5): p. e19640
  61. Novillo F,Medina J,Rodr
    Genetic analysis reveals a complex regulatory network modulating CBF gene expression and Arabidopsis response to abiotic stress.
    J. Exp. Bot., 2012. 63(1): p. 293-304
  62. Lee CM,Thomashow MF
    Photoperiodic regulation of the C-repeat binding factor (CBF) cold acclimation pathway and freezing tolerance in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. U.S.A., 2012. 109(37): p. 15054-9
  63. Mao D,Chen C
    Colinearity and similar expression pattern of rice DREB1s reveal their functional conservation in the cold-responsive pathway.
    PLoS ONE, 2012. 7(10): p. e47275
  64. Akhtar M, et al.
    DREB1/CBF transcription factors: their structure, function and role in abiotic stress tolerance in plants.
    J. Genet., 2012. 91(3): p. 385-95
  65. Kang J, et al.
    Natural variation of C-repeat-binding factor (CBFs) genes is a major cause of divergence in freezing tolerance among a group of Arabidopsis thaliana populations along the Yangtze River in China.
    New Phytol., 2013. 199(4): p. 1069-80
  66. Keily J, et al.
    Model selection reveals control of cold signalling by evening-phased components of the plant circadian clock.
    Plant J., 2013. 76(2): p. 247-57
  67. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
  68. Shi H, et al.
    The Cysteine2/Histidine2-Type Transcription Factor ZINC FINGER OF ARABIDOPSIS THALIANA6 Modulates Biotic and Abiotic Stress Responses by Activating Salicylic Acid-Related Genes and C-REPEAT-BINDING FACTOR Genes in Arabidopsis.
    Plant Physiol., 2014. 165(3): p. 1367-1379
  69. Oakley CG,Ågren J,Atchison RA,Schemske DW
    QTL mapping of freezing tolerance: links to fitness and adaptive trade-offs.
    Mol. Ecol., 2014. 23(17): p. 4304-15
  70. Miyazaki Y,Abe H,Takase T,Kobayashi M,Kiyosue T
    Overexpression of LOV KELCH protein 2 confers dehydration tolerance and is associated with enhanced expression of dehydration-inducible genes in Arabidopsis thaliana.
    Plant Cell Rep., 2015. 34(5): p. 843-52
  71. Park S, et al.
    Regulation of the Arabidopsis CBF regulon by a complex low-temperature regulatory network.
    Plant J., 2015. 82(2): p. 193-207
  72. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
  73. Sazegari S,Niazi A,Ahmadi FS
    A study on the regulatory network with promoter analysis for Arabidopsis DREB-genes.
    Bioinformation, 2015. 11(2): p. 101-6
  74. Li Y,Xu B,Du Q,Zhang D
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