PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT3G57670.1

Common Name

F15B8.140, NTT, WIP2

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

C2H2

Protein Properties

Length: 383aa MW: 43337.1 Da PI: 6.8718

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT3G57670.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16	3.4e-05	217	236	1	20
EEETTTTEEESSHHHHHHHH CS zf-C2H2 1 ykCpdCgksFsrksnLkrHi 20 ++Cp C k+F+r n++ H+ AT3G57670.1 217 FSCPVCFKTFNRYNNMQMHM 236 89*****************9 PP
2	zf-C2H2	14.4	0.00011	301	323	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 + C +Cgk F + + ++H +++ AT3G57670.1 301 FMCRKCGKAFAVRGDWRTHEKNC 323 89*****************9987 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00355	0.38	217	239	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	9.64	217	244	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	5.6E-6	217	236	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	219	239	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	1.88E-6	283	321	No hit	No description
Gene3D	G3DSA:3.30.160.60	1.1E-5	297	321	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	8.808	301	321	IPR007087	Zinc finger, C2H2
SMART	SM00355	49	301	321	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009860	Biological Process	pollen tube growth
GO:0010500	Biological Process	transmitting tissue development
GO:1990058	Biological Process	fruit replum development
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0008270	Molecular Function	zinc ion binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000037	anatomy	shoot apex
PO:0000293	anatomy	guard cell
PO:0009009	anatomy	plant embryo
PO:0009010	anatomy	seed
PO:0009031	anatomy	sepal
PO:0009032	anatomy	petal
PO:0009046	anatomy	flower
PO:0009052	anatomy	flower pedicel
PO:0020003	anatomy	plant ovule
PO:0020006	anatomy	funicle
PO:0020102	anatomy	portion of transmitting tissue
PO:0025022	anatomy	collective leaf structure
PO:0025268	anatomy	fruit septum
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0001185	developmental stage	plant embryo globular stage
PO:0007611	developmental stage	petal differentiation and expansion stage
PO:0007616	developmental stage	flowering stage

Sequence ? help Back to Top
Protein Sequence Length: 383 aa Download sequence Send to blast
MTDPYSNFFT DWFKSNPFHH YPNSSTNPSP HPLPPVTPPS SFFFFPQSGD LRRPPPPPTP 60 PPSPPLREAL PLLSLSPANK QQDHHHNHDH LIQEPPSTSM DVDYDHHHQD DHHNLDDDDH 120 DVTVALHIGL PSPSAQEMAS LLMMSSSSSS SRTTHHHEDM NHKKDLDHEY SHGAVGGGED 180 DDEDSVGGDG GCRISRLNKG QYWIPTPSQI LIGPTQFSCP VCFKTFNRYN NMQMHMWGHG 240 SQYRKGPESL RGTQPTGMLR LPCYCCAPGC RNNIDHPRAK PLKDFRTLQT HYKRKHGIKP 300 FMCRKCGKAF AVRGDWRTHE KNCGKLWYCI CGSDFKHKRS LKDHIKAFGN GHGAYGIDGF 360 DEEDEPASEV EQLDNDHESM QSK

Sequence ? help Back to Top

Protein Sequence Length: 383 aa Download sequence Send to blast

MTDPYSNFFT DWFKSNPFHH YPNSSTNPSP HPLPPVTPPS SFFFFPQSGD LRRPPPPPTP  60
PPSPPLREAL PLLSLSPANK QQDHHHNHDH LIQEPPSTSM DVDYDHHHQD DHHNLDDDDH  120
DVTVALHIGL PSPSAQEMAS LLMMSSSSSS SRTTHHHEDM NHKKDLDHEY SHGAVGGGED  180
DDEDSVGGDG GCRISRLNKG QYWIPTPSQI LIGPTQFSCP VCFKTFNRYN NMQMHMWGHG  240
SQYRKGPESL RGTQPTGMLR LPCYCCAPGC RNNIDHPRAK PLKDFRTLQT HYKRKHGIKP  300
FMCRKCGKAF AVRGDWRTHE KNCGKLWYCI CGSDFKHKRS LKDHIKAFGN GHGAYGIDGF  360
DEEDEPASEV EQLDNDHESM QSK

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
At.28310	0.0	bud

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	30694696	0.0
Genevisible	251592_at	0.0
Expression Atlas	AT3G57670	-
AtGenExpress	AT3G57670	-
ATTED-II	AT3G57670	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in developing carpels (PubMed:17600712). Expressed in the shoot apical meristem and the replum (PubMed:25039392). {ECO:0000269\|PubMed:17600712}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional regulator required for normal differentiation of the ovary transmitting tract cells and pollen tube growth. In Arabidopsis, the transmitting tract facilitates the transport of pollen tubes to the ovules for fertilization (PubMed:17600712). May play a role in the regulation of AGL8/FUL, which is required for normal pattern of cell division, expansion and differentiation during morphogenesis of the silique (PubMed:23515580). Plays a role in replum development by the activation of the homeobox protein KNAT1 (PubMed:25039392). {ECO:0000269\|PubMed:17600712, ECO:0000269\|PubMed:23515580, ECO:0000269\|PubMed:25039392}.

Function -- GeneRIF ? help Back to Top
Required for transmitting-tract development; mutations cause reduced fertility by severely inhibiting pollen-tube movement [NTT] [PMID: 17600712] These results indicate that NTT suppresses FUL, indicating a potential role in patterning of the silique. [PMID: 23515580] NTT loss of function leads to reduced replum width and cell number, whereas increased expression promotes replum enlargement. NTT activates the homeobox gene BP, which, together with RPL, is important for replum development. [PMID: 25039392]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT3G57670.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Interaction ? help Back to Top
Source	Intact With
IntAct	Search Q9SVY1

Phenotype -- Disruption Phenotype ? help Back to Top
Source	Description
UniProt	DISRUPTION PHENOTYPE: Reduced fertility, fruit length and seed set (PubMed:17600712). Reduced replum width and cell number (PubMed:25039392). {ECO:0000269\|PubMed:17600712, ECO:0000269\|PubMed:25039392}.

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT3G57670

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AF254447	0.0	AF254447.1 Arabidopsis thaliana WIP2 protein (WIP2) mRNA, complete cds.
GenBank	BT021089	0.0	BT021089.1 Arabidopsis thaliana At3g57670 gene, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_191326.1	0.0	C2H2-type zinc finger family protein
Swissprot	Q9SVY1	0.0	ZWIP2_ARATH; Zinc finger protein WIP2
TrEMBL	A0A178VLW5	0.0	A0A178VLW5_ARATH; WIP2
STRING	AT3G57670.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM239	28	237
Representative plant	OGRP410	15	97

Link Out ? help Back to Top
Phytozome	AT3G57670.1
Entrez Gene	824936
iHOP	AT3G57670
wikigenes	AT3G57670

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] Sagasser M,Lu GH,Hahlbrock K,Weisshaar B A. thaliana TRANSPARENT TESTA 1 is involved in seed coat development and defines the WIP subfamily of plant zinc finger proteins. Genes Dev., 2002. 16(1): p. 138-49 [PMID:11782451] Dal Bosco C, et al. Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana. J. Biol. Chem., 2004. 279(2): p. 1060-9 [PMID:14576160] Yamada K, et al. Empirical analysis of transcriptional activity in the Arabidopsis genome. Science, 2003. 302(5646): p. 842-6 [PMID:14593172] Englbrecht CC,Schoof H,B Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome. BMC Genomics, 2004. 5(1): p. 39 [PMID:15236668] Crawford BC,Ditta G,Yanofsky MF The NTT gene is required for transmitting-tract development in carpels of Arabidopsis thaliana. Curr. Biol., 2007. 17(13): p. 1101-8 [PMID:17600712] Dortay H, et al. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. J. Proteome Res., 2008. 7(9): p. 3649-60 [PMID:18642946] Appelhagen I, et al. Weird fingers: functional analysis of WIP domain proteins. FEBS Lett., 2010. 584(14): p. 3116-22 [PMID:20541552] Crawford BC,Yanofsky MF HALF FILLED promotes reproductive tract development and fertilization efficiency in Arabidopsis thaliana. Development, 2011. 138(14): p. 2999-3009 [PMID:21693516] Chung KS,Lee JH,Lee JS,Ahn JH Fruit indehiscence caused by enhanced expression of NO TRANSMITTING TRACT in Arabidopsis thaliana. Mol. Cells, 2013. 35(6): p. 519-25 [PMID:23515580] Marsch-Mart The NTT transcription factor promotes replum development in Arabidopsis fruits. Plant J., 2014. 80(1): p. 69-81 [PMID:25039392] Crawford BC, et al. Plant development. Genetic control of distal stem cell fate within root and embryonic meristems. Science, 2015. 347(6222): p. 655-9 [PMID:25612610] Zhou X,Groves NR,Meier I Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Nucleus, 2015. 6(2): p. 144-53 [PMID:25759303] Boex-Fontvieille E, et al. An Ethylene-Protected Achilles' Heel of Etiolated Seedlings for Arthropod Deterrence. Front Plant Sci, 2016. 7: p. 1246 [PMID:27625656]