PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

AT3G18010.1

Common Name

MEB5.20, MEB5.23, WOX1

Organism

Arabidopsis thaliana

Taxonomic ID

3702

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis

Family

WOX

Protein Properties

Length: 350aa MW: 40142.7 Da PI: 7.4269

Description

WUSCHEL related homeobox 1

Gene Model

Gene Model ID	Type	Source	Coding Sequence
AT3G18010.1	genome	TAIR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	68.7	7.5e-22	75	134	3	57
--SS--HHHHHHHHHHHHH.SSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS Homeobox 3 kRttftkeqleeLeelFek.nrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57 +R+++t++ql++Leel+++ +r+psa+++++++++l +++ ++V++WFqN++a+e++ AT3G18010.1 75 SRWNPTPDQLRVLEELYRQgTRTPSADHIQQITAQLrrygKIEGKNVFYWFQNHKARERQ 134 7***************99************************************97 PP
2	Wus_type_Homeobox	117.9	4.5e-38	74	136	3	65
Wus_type_Homeobox 3 rtRWtPtpeQikiLeelyksGlrtPnkeeiqritaeLeeyGkiedkNVfyWFQNrkaRerqkq 65 ++RW+Ptp+Q+++Leely++G+rtP++++iq+ita+L++yGkie+kNVfyWFQN+kaRerqk+ AT3G18010.1 74 SSRWNPTPDQLRVLEELYRQGTRTPSADHIQQITAQLRRYGKIEGKNVFYWFQNHKARERQKR 136 79***********************************************************95 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00389	2.1E-5	72	139	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	4.3E-9	75	134	IPR009057	Homeodomain-like
Pfam	PF00046	1.5E-19	75	134	IPR001356	Homeobox domain
SuperFamily	SSF46689	4.38E-12	75	140	IPR009057	Homeodomain-like
CDD	cd00086	7.32E-6	76	136	No hit	No description
PROSITE profile	PS50071	10.867	80	135	IPR001356	Homeobox domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0048513	Biological Process	animal organ development
GO:0099402	Biological Process	plant organ development
GO:0005634	Cellular Component	nucleus
GO:0005829	Cellular Component	cytosol
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Plant Ontology ? help Back to Top
PO Term	PO Category	PO Description
PO:0000015	anatomy	cotyledon primordium
PO:0000293	anatomy	guard cell
PO:0009006	anatomy	shoot system
PO:0001078	developmental stage	plant embryo cotyledonary stage
PO:0004507	developmental stage	plant embryo bilateral stage

Sequence ? help Back to Top
Protein Sequence Length: 350 aa Download sequence Send to blast
MWTMGYNEGG ADSFNGGRKL RPLIPRLTSC PTAAVNTNSD HRFNMAVVTM TAEQNKRELM 60 MLNSEPQHPP VMVSSRWNPT PDQLRVLEEL YRQGTRTPSA DHIQQITAQL RRYGKIEGKN 120 VFYWFQNHKA RERQKRRRQM ETGHEETVLS TASLVSNHGF DKKDPPGYKV EQVKNWICSV 180 GCDTQPEKPS RDYHLEEPAN IRVEHNARCG GDERRSFLGI NTTWQMMQLP PSFYSSSHHH 240 HQRNLILNSP TVSSNMSNSN NAVSASKDTV TVSPVFLRTR EATNTETCHR NGDDNKDQEQ 300 HEDCSNGELD HQEQTLELFP LRKEGFCSDG EKDKNISGIH CFYEFLPLKN

Sequence ? help Back to Top

Protein Sequence Length: 350 aa Download sequence Send to blast

MWTMGYNEGG ADSFNGGRKL RPLIPRLTSC PTAAVNTNSD HRFNMAVVTM TAEQNKRELM  60
MLNSEPQHPP VMVSSRWNPT PDQLRVLEEL YRQGTRTPSA DHIQQITAQL RRYGKIEGKN  120
VFYWFQNHKA RERQKRRRQM ETGHEETVLS TASLVSNHGF DKKDPPGYKV EQVKNWICSV  180
GCDTQPEKPS RDYHLEEPAN IRVEHNARCG GDERRSFLGI NTTWQMMQLP PSFYSSSHHH  240
HQRNLILNSP TVSSNMSNSN NAVSASKDTV TVSPVFLRTR EATNTETCHR NGDDNKDQEQ  300
HEDCSNGELD HQEQTLELFP LRKEGFCSDG EKDKNISGIH CFYEFLPLKN

Expression -- Microarray ? help Back to Top
Source	ID	E-value
GEO	145338657	0.0
Expression Atlas	AT3G18010	-
AtGenExpress	AT3G18010	-

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Specifically expressed during initiation of the shoot apical meristem, when cotyledonary primordia arise at the flanks of the apical embryo domain phase. Confined to the initiating vascular primordium of the cotyledons during heart and torpedo stages, but only weakly expressed during bent cotyledon stage. {ECO:0000269\|PubMed:14711878}.

Functional Description ? help Back to Top
Source	Description
TAIR	Encodes a WUSCHEL-related homeobox gene family member with 65 amino acids in its homeodomain. Proteins in this family contain a sequence of eight residues (TLPLFPMH) downstream of the homeodomain called the WUS box. Its mRNA is expressed in the initiating vascular primordium of the cotyledons during heart and torpedo stages.
UniProt	Transcription factor which may be involved in developmental processes. {ECO:0000250}.

Function -- GeneRIF ? help Back to Top
Data indicate a conserved role for WOX1 genes in regulating lateral organ development. [PMID: 19717616] WOX1 plays an important role in meristem development in Arabidopsis. [PMID: 21658178] Specific expression of PRS and WOX1 in a domain between the adaxial and abaxial domains is important for lateral-specific blade outgrowth and margin-specific cell fate. [PMID: 22374393] These data points to a general requirement for AS2 repression in meristematic regions to allow cell proliferation. [PMID: 25807065] Adaxial-expressed MONOPTEROS (MP) and abaxial-enriched auxin together act as positional cues for patterning the WOX domain. MP directly binds to the WOX1 and PRS promoters and activates their expression. [PMID: 28943086]

Cis-element ? help Back to Top
Source	Link
PlantRegMap	AT3G18010.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Phenotype -- Mutation ? help Back to Top
Source	ID
T-DNA Express	AT3G18010

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY251394	0.0	AY251394.1 Arabidopsis thaliana WOX1 protein mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_188428.3	0.0	WUSCHEL related homeobox 1
Swissprot	Q6X7K0	0.0	WOX1_ARATH; WUSCHEL-related homeobox 1
TrEMBL	A0A178V7E4	0.0	A0A178V7E4_ARATH; WOX1
STRING	AT3G18010.1	0.0	(Arabidopsis thaliana)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7397	27	41
Representative plant	OGRP8416	7	16

Link Out ? help Back to Top
Phytozome	AT3G18010.1
Entrez Gene	821325
iHOP	AT3G18010
wikigenes	AT3G18010

Publications ? help Back to Top
Riechmann JL, et al. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Science, 2000. 290(5499): p. 2105-10 [PMID:11118137] R Rapid identification of Arabidopsis insertion mutants by non-radioactive detection of T-DNA tagged genes. Plant J., 2002. 32(2): p. 243-53 [PMID:12383089] Haecker A, et al. Expression dynamics of WOX genes mark cell fate decisions during early embryonic patterning in Arabidopsis thaliana. Development, 2004. 131(3): p. 657-68 [PMID:14711878] Czechowski T,Bari RP,Stitt M,Scheible WR,Udvardi MK Real-time RT-PCR profiling of over 1400 Arabidopsis transcription factors: unprecedented sensitivity reveals novel root- and shoot-specific genes. Plant J., 2004. 38(2): p. 366-79 [PMID:15078338] Vandenbussche M, et al. Differential recruitment of WOX transcription factors for lateral development and organ fusion in Petunia and Arabidopsis. Plant Cell, 2009. 21(8): p. 2269-83 [PMID:19717616] Hirakawa Y,Kondo Y,Fukuda H TDIF peptide signaling regulates vascular stem cell proliferation via the WOX4 homeobox gene in Arabidopsis. Plant Cell, 2010. 22(8): p. 2618-29 [PMID:20729381] Zhang X,Zong J,Liu J,Yin J,Zhang D Genome-wide analysis of WOX gene family in rice, sorghum, maize, Arabidopsis and poplar. J Integr Plant Biol, 2010. 52(11): p. 1016-26 [PMID:20977659] Ito J, et al. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J. Proteome Res., 2011. 10(4): p. 1571-82 [PMID:21166475] Zhang Y, et al. Over-expression of WOX1 leads to defects in meristem development and polyamine homeostasis in Arabidopsis. J Integr Plant Biol, 2011. 53(6): p. 493-506 [PMID:21658178] Nakata M, et al. Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX genes in early development of leaves in Arabidopsis. Plant Cell, 2012. 24(2): p. 519-35 [PMID:22374393] Nakata M,Okada K The three-domain model: a new model for the early development of leaves in Arabidopsis thaliana. Plant Signal Behav, 2012. 7(11): p. 1423-7 [PMID:22951404] Zhang F,Tadege M Repression of AS2 by WOX family transcription factors is required for leaf development in Medicago and Arabidopsis. Plant Signal Behav, 2015. 10(7): p. e993291 [PMID:25807065] Guan C, et al. Spatial Auxin Signaling Controls Leaf Flattening in Arabidopsis. Curr. Biol., 2017. 27(19): p. 2940-2950.e4 [PMID:28943086]